2006
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
Sun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia. Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Dorsal root gangliaNociceptive neuronsRoot gangliaCompressed dorsal root ganglionIntact dorsal root gangliaSmall DRG neuronsProportion of neuronsChemoattractant protein-1Action potential widthNonselective cation conductanceMagnitude of depolarizationCCD neuronsChronic compressionDRG neuronsExcitatory effectsReceptor CCR2Nociceptive propertiesIntact gangliaNeuronal expressionInward currentsNeuronsCurrent clampGangliaReversal potential
1998
Patch clamp recording from the intact dorsal root ganglion
Zhang J, Donnelly D, LaMotte R. Patch clamp recording from the intact dorsal root ganglion. Journal Of Neuroscience Methods 1998, 79: 97-103. PMID: 9531465, DOI: 10.1016/s0165-0270(97)00164-7.Peer-Reviewed Original ResearchConceptsPatch-clamp recordingsConduction velocityAction potentialsSciatic nerveC cellsIntact dorsal root gangliaDorsal root ganglion cellsDorsal root gangliaAxonal conduction velocityGanglion sheathL5 DRGDRG cellsRoot gangliaGanglion cellsAP thresholdBeta cellsClamp recordingsSodium currentAdeltaCurrent clampConnective tissueVoltage clampNerveGangliaTTX
1996
Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction
Petersen M, Zhang J, Zhang J, LaMotte R. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain 1996, 67: 391-397. PMID: 8951934, DOI: 10.1016/0304-3959(96)03146-6.Peer-Reviewed Original ResearchConceptsDorsal root ganglion cellsUninjured nerveGanglion cellsSpontaneous activityWhole-cell patch-clamp recordingsAbnormal spontaneous activityChronic nerve constrictionPeripheral nerve injuryPrimary sensory neuronsPatch-clamp recordingsMedium-sized cellsNerve constrictionTight ligationNerve injuryDRG cellsSciatic nerveNormal nervesAdult ratsSensory neuronsNerveNorepinephrineLow dosesAction potentialsCultures 11Current clamp