1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensation
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuli