Nalini Vadivelu, MBBS, DNB, MD
Professor Emeritus of AnesthesiologyCards
Appointments
Contact Info
Anesthesiology
PO Box 208051, 333 Cedar Street, TMP 3
New Haven, CT 06520-8051
United States
About
Titles
Professor Emeritus of Anesthesiology
Biography
Dr. Nalini Vadivelu is Professor of Anesthesiology at Yale New Haven Hospital , Yale University. Dr. Vadivelu received her medical degree MBBS from Christian Medical College in 1978 and completed a rotating internship at Christian Medical college and Hospital, Vellore , India in January1978. She received a doctor of Medicine MD in Biochemistry from Jawaharial Institute of Post Graduate Medical Education and Research in Pondicherry in India in 1985. . Later, Dr. Vadivelu completed a second residency in Anesthesiology at the University of Southern California and a Pain Management fellowship at Memorial Sloan Kettering Cancer Center in New York. In 2002, Dr. Vadivelu joined the Yale School of Medicine faculty. While at Yale, she has been instrumental in the development of a clinical program for Ambulatory Pain Control at the Ambulatory Surgery Center and the incorporation of pain education into the Yale medical school curriculum with special emphasis on ambulatory pain management. Dr. Vadivelu has made significant contributions to scientific literature in the fields of pain management and substance abuse,. She has also invented two medical devices to improve safety in Anesthesia for which she has 18 patents worldwide. The invented medical devices are a novel laryngeal mask airway and a new nasogastric tube both of which have led to multiple patents in several countries .CIP #1 Family of patents based on PCT/US2014/057059
- European patent No E.P 3049124
- U.S Patent No 10,549055
- Australian Patent No 2014324114
- Indian Patent No 411192
CIP#2. Family of Patents Based on PCT/US2019/013113
1) European Patent No. EP 3737447
2) U.S. Patent No. 11,077,271
3)Chinese Patent Application No. 201980008116
4) Indian Patent Application No. 202017027986
5)Australian Patent Application No. 2019206581
Parent Family of Patents based on PCT/US2006/010623
- Europen Patent no EP 1861154
2) Australian Patent no 2006229933
3) Australian Patent No 2011253968
4) US Patent No 8105316
5 ) US. Patent No: 9687622
I6) ndian Patent No 250896
7) Chinese Patent No ZI 200680009457.2
8) Hong Kong Patent No HK1118489
9) Chinese Patent No. 201010157084.1
10) HongKong Patent No HK1147451
Appointments
Anesthesiology
ProfessorPrimaryAnesthesiology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Memorial Sloan Kettering Cancer Center (2002)
- Resident
- University of Southern California (1997)
- Diplomate of National Board ( Biochemistry)
- Christian medical college , Vellore 632002 India (1986)
- MD
- JIPMER, Biochemistry (1985)
- Resident
- Jawaharial Institute of Post Graduate Medical Education and Research (1985)
- Intern
- Christian medical college hospital (1978)
- MBBS
- Christian Medical College (1976)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1999
Research
Overview
My research in ambulatory pain control can be divided into several subtopics as detailed below
1) Perioperative pain management in ambulatory surgery
My interest in the area of perioperative pain management in ambulatory surgery has led to clinical investigations, extensive literature searches and scholarship in this area. My pain research studies and scholarly contributions in the control of perioperative pain at the ambulatory surgery center aims at increasing awareness and improving pain control in ambulatory care centers worldwide. These works include:
. 2) Alternative therapies for perioperative treatment of pain in the ambulatory setting. Managing pain control in the presence of alternative therapies is a challenge and research in this area at the ambulatory surgery center in which I participate is ongoing
3) Analgesics for pain control in ambulatory surgery I have a long-term interest in the analgesics taken by patients for the control of pain who then present for ambulatory surgery. My scholarly writings and research efforts have been directed at increasing awareness of the use of these drugs, and suggesting ideal ways to manage pain in these patients safely within the ambulatory setting.
4) Regional blocks and Interventional pain management in ambulatory surgery
Regional blocks are one of the multimodal treatments used to control pain in the ambulatory setting. Patients with chronic pain presenting for ambulatory surgery sometimes have implanted pain control devices and perioperative management of these patients are a great challenge. My research studies and scholarship in these areas has always focused on safety first.
. 5) Research and Scholarship on perioperative pain control education for ambulatory surgery.
I have been involved in evaluating research surveys of patients undergoing ambulatory surgery at Yale, which found that physicians who are not trained in pain management treated 90 percent of patients for their painful conditions. This highlighted the need to educate all physicians and health care professionals in the field of pain management. The primary care provider helps to best achieve optimum pain management of pain patients in the ambulatory surgery center through preoperative preparation of these patients and postoperative care. This collaboration is best achieved by starting pain education early in one’s career, as in at the medical school level. Seeing this has led me to produce scholarly works in order to educate health care professionals so they can provide optimum pain management worldwide with special emphasis on pain management at the ambulatory surgery center.
6)Perioperative management of the opioid dependent, drug tolerant, drug dependent and substance abuse patient in ambulatory surgery
With the rapidly increasing numbers of patients with opioid dependence, substance abuse and addiction presenting for ambulatory surgery, I have an ongoing interest on how to improve the care of these patients in the ambulatory surgery center. As a result of clinical observations, intense literature searches and studies on the pain management of patients with drug tolerance, drug dependence and addiction, at the ambulatory surgery center, I and physicians from several national universities and international universities have researched and written several manuscripts on the topic and have also been an edited a textbook on the management of patients with Substance Abuse in the Outpatient Setting .
7) Pain management for specific surgeries performed in ambulatory surgery centers
I have focused my clinical research studies and scholarly works on pain control for specific surgeries in collaboration with several physicians who commonly performed these procedures in the ambulatory surgery center. My collaborative research efforts at the Yale Ambulatory Surgery Center have been performed in conjunction with Yale physicians in the Departments of Surgery Podiatry , Gynecology, Ophthalmology and Plastic Surgery.
8) Research in Caring for the palliative care patients in ambulatory surgery
. To further understand the problem of pain control in palliative care patients undergoing surgery in the ambulatory setting, as well to increase awareness of the challenge of caring for these patients.I have conducted research in collaboration with other physicians on the pain management of terminally ill patients and palliative care patients having surgery,
The inventions towards medical devices have focused on inventing a novel laryngeal mask airway and a new nasogastric tube both of which have led to multiple patents details are shown below:
Patents
CIP #1 Family of patents based on PCT/US2014/057059
- European patent No E.P 3049124
- U.S Patent No 10,549055
- Australian Patent No 2014324114
- Indian Patent No 411192
CIP#2. Family of Patents Based on PCT/US2019/013113
1) European Patent No. EP 3737447
2) U.S. Patent No. 11,077,271
3)Chinese Patent Application No. 201980008116
4) Indian Patent Application No. 202017027986
5)Australian Patent Application No. 2019206581
Parent Family of Patents based on PCT/US2006/010623
- Europen Patent no EP 1861154
2) Australian Patent no 2006229933
3) Australian Patent No 2011253968
4) US Patent No 8105316
5 ) US. Patent No: 9687622
I6) ndian Patent No 250896
7) Chinese Patent No ZI 200680009457.2
8) Hong Kong Patent No HK1118489
9) Chinese Patent No. 201010157084.1
10) HongKong Patent No HK1147451
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Kanishka Rajput, FASA, MBBS
Jinlei Li, MD, PhD
Robert Chow, MD
Andrew Duffy, MD, FACS, FASMBS
Donna-Ann Thomas, MD
Jessica Feinleib, MD, PhD, FASA
Publications
ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting
Zwolinski N, Patel K, Vadivelu N, Kodumudi G, Kaye A. ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting. Current Pain And Headache Reports 2023, 27: 65-79. PMID: 37079258, PMCID: PMC10116112, DOI: 10.1007/s11916-023-01108-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSubstance use disordersSubstance use disorder patientsAmbulatory patientsUse disordersDisorder patientsERAS protocolPerioperative pain managementAmbulatory surgery settingHospital quality metricsAmbulatory surgical settingAmbulatory surgery casesPerioperative protocolPain managementAdverse outcomesAmbulatory surgeryPharmacodynamic profileSurgery settingAmbulatory proceduresSurgery casesClinical dataEarly recoveryAbused substancesSurgical settingPatientsSubspecialty groupsKetamine
Shergill S, Vadivelu N. Ketamine. 2023, 195-205. DOI: 10.1007/978-3-031-21291-8_13.Peer-Reviewed Original ResearchCitationsConceptsPost-operative pain controlPost-operative analgesiaSympathetic nervous systemMaintenance of anesthesiaMultiple surgical proceduresMu-opioid receptorsNMDA receptor antagonismComplete anestheticERAS protocolOperative analgesiaAnalgesic benefitPain controlPulmonary diseaseSeptic shockChronic painReceptor antagonismSubanesthetic dosesOpioid receptorsPotent analgesicSurgical proceduresHepatic enzymesNervous systemPartial agonistKetaminePatientsAnticonvulsants
Popovitz E, Li J, Vadivelu N. Anticonvulsants. 2023, 139-146. DOI: 10.1007/978-3-031-21291-8_9.ChaptersConceptsDiabetic peripheral neuropathySpinal cord injuryPerioperative settingRole of anticonvulsantsHerpetic neuralgiaMultimodal analgesiaNeuropathic painSurgery protocolPeripheral neuropathyCord injuryPrimary medicationThoracic proceduresAssociated pathologyEnhanced recoveryAnalgesiaNeuropathyPainAnticonvulsantsOptimal dosageGabapentinoidsNeuralgiaMedicationsHIVGabapentinPregabalinFifty years of ambulatory anaesthesia: Stepping out and stepping forward!
Mitra S, Arora S, Vadivelu N. Fifty years of ambulatory anaesthesia: Stepping out and stepping forward! Indian Journal Of Anaesthesia 2024, 68: 320-322. PMID: 38586261, PMCID: PMC10993947, DOI: 10.4103/ija.ija_857_23.Peer-Reviewed Original ResearchAltmetricEvolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice
Vadivelu N, Kodumudi G, Leffert L, Pierson D, Rein L, Silverman M, Cornett E, Kaye A. Evolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice. Advances In Therapy 2023, 40: 828-843. PMID: 36637690, PMCID: PMC9838367, DOI: 10.1007/s12325-022-02406-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNasogastric tubeShort-term parenteral nutritionTerm parenteral nutritionManagement of complicationsAdministration of medicationsMultiple medical specialtiesTechnique of insertionResuscitative toolBowel obstructionParenteral nutritionChronic careTherapeutic roleClinical practiceComplicationsSurgical specialtiesCurrent conceptsMedical specialtiesRecent updatesCorrect positioningSpecialtiesContraindicationsMedicationsObstructionStomachAdministrationEnhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review
Rajput K, Shergill S, Chow RM, Vadivelu N, Kaye AD. Enhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review. Current Pain And Headache Reports 2022, 26: 93-102. PMID: 35072920, DOI: 10.1007/s11916-022-01009-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsMeSH Keywords and ConceptsConceptsOpioid usePersistent post-surgical painNon-opioid strategiesNon-opioid therapiesOpioid-sparing strategiesOverprescribing of opioidsPostoperative pain scoresMultimodal analgesic approachPost-surgical painSide effect profileNon-opioid analgesicsRecent FindingsSeveral studiesERAS protocolOpioid protocolAnalgesic approachBreakthrough painHospital stayMultimodal analgesiaPain scoresAcute painOral ketaminePostoperative periodEffect profilePatient recoveryGood quality researchAmbulatory Pain Management in the Pediatric Patient Population
Oliver JA, Oliver LA, Aggarwal N, Baldev K, Wood M, Makusha L, Vadivelu N, Lichtor L. Ambulatory Pain Management in the Pediatric Patient Population. Current Pain And Headache Reports 2022, 26: 15-23. PMID: 35129824, DOI: 10.1007/s11916-022-00999-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPain managementPostoperative painPediatric ambulatory surgical patientsPostoperative pain controlAmbulatory surgical patientsSevere postoperative painExtent of painPeripheral nerve blocksPediatric ambulatory surgeryPediatric patient populationNon-pharmacological techniquesRandomized control studyEvidence-based approachMultimodal analgesiaPain controlSurgical patientsNerve blockPediatric populationAmbulatory surgeryPatient populationMost centersControl studyPainScientific evidenceMultimodal approachAnalgesia for Gynecologic Oncologic Surgeries: A Narrative Review
Patel K, Shergill S, Vadivelu N, Rajput K. Analgesia for Gynecologic Oncologic Surgeries: A Narrative Review. Current Pain And Headache Reports 2022, 26: 1-13. PMID: 35118596, DOI: 10.1007/s11916-022-00998-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsMeSH Keywords and ConceptsConceptsHyperthermic intraperitoneal chemotherapyCytoreductive surgeryPain managementNarrative reviewOptimal perioperative pain managementGynecologic oncologic surgeryPerioperative analgesic planPostoperative pain managementPerioperative pain managementLocal anesthetic infiltrationInvasive cancer surgeryMultimodal analgesicsPreemptive analgesiaMultimodal analgesiaPostoperative painAnalgesic planAnesthetic infiltrationGynecologic malignanciesIntraperitoneal chemotherapyPerioperative periodSurgery protocolThoracic epiduralCancer surgeryChronic painNeuraxial techniquesWeaning Protocols After Ambulatory Surgery
Aggarwal N, Zafar J, Kodumudi G, Vadivelu N, Laurans M, Rajput K. Weaning Protocols After Ambulatory Surgery. 2021, 369-377. DOI: 10.1007/978-3-030-55262-6_28.ChaptersConceptsHospital-based outpatient departmentsAmbulatory surgery centersPostoperative painUnplanned admissionsAmbulatory surgeryLong-term opioid usersNumber of surgeriesUnanticipated admissionMultimodal analgesiaOpioid prescriptionsPain medicationPerioperative analgesiaIntractable nauseaOutpatient departmentOpioid usersAmbulatory proceduresSurgery centersWeaning protocolHospital careOrthopedic proceduresSurgeryPainPatientsAdmissionMajor causeSpecial Considerations – Indwelling Spinal Cord Stimulators and Intrathecal Pumps
Beals C, Chow R, Vadivelu N, Rajput K. Special Considerations – Indwelling Spinal Cord Stimulators and Intrathecal Pumps. 2021, 335-343. DOI: 10.1007/978-3-030-55262-6_25.ChaptersCitationsConceptsSpinal cord stimulatorContinuous opioid useChronic pain patientsPaucity of literatureIT clonidineCentral sensitizationMultimodal analgesiaSystemic medicationsOpioid toleranceOpioid usePerioperative managementPain patientsPain physiciansPump dysfunctionIntrathecal pumpNeuraxial anesthesiaAmbulatory surgeryLong actingRegional anesthesiaPatientsSurgeryUnique subsetNormal functionAnesthesiaStimulator
Links & Media
News
- May 03, 2020
Nalini Vadivelu was featured in international quarterly newsletter, “Voices of Vellore” for her donation of approximately 20,000 US dollars worth of GLA Masks.
- January 28, 2010
Collaborative Study Shows Value of Urine Testing in Pain Management
- May 16, 2008
Symposium on Pain Management Aimed at Medical School Students
Get In Touch
Contacts
Anesthesiology
PO Box 208051, 333 Cedar Street, TMP 3
New Haven, CT 06520-8051
United States