2014
Characterization of Cardiac Dysfunction in Sepsis
Zaky A, Deem S, Bendjelid K, Treggiari MM. Characterization of Cardiac Dysfunction in Sepsis. Shock 2014, 41: 12-24. PMID: 24351526, DOI: 10.1097/shk.0000000000000065.Peer-Reviewed Original ResearchConceptsSepsis-induced cardiomyopathyIntrinsic contractile functionContractile functionIntrinsic myocardial dysfunctionIntrinsic myocardial functionGlobal ventricular performanceCommon morbid conditionSevere sepsisSeptic shockCardiac dysfunctionHemodynamic assessmentMyocardial dysfunctionCardiac outputPeripheral circulationVentricular performanceAdditional potential mechanismMyocardial functionMorbid conditionsClinical characterizationCurrent evidenceHeart functionPhysiologic mechanismsPhysiopathological pathwaysAnimal modelsCellular signaling mechanisms
2008
Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade
ÅNEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta Anaesthesiologica Scandinavica 2008, 53: 203-209. PMID: 19094177, DOI: 10.1111/j.1399-6576.2008.01834.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCardiac Output, LowCardiac TamponadeDrug Evaluation, PreclinicalEndothelin Receptor AntagonistsEndothelin-1FemaleLactatesLiver CirculationMaleModels, AnimalOxygenOxygen ConsumptionPyridinesSplanchnic CirculationSus scrofaTetrazolesVascular ResistanceVasoconstrictionConceptsLaser Doppler flowMesenteric oxygen deliveryLow CO stateBaseline valuesCardiac tamponadeOxygen deliveryBlood flowPorcine modelPortal venous blood flowHepatic artery blood flowLow cardiac output stateET-1 blockadeMesenteric oxygen extractionMesenteric vascular resistanceArtery blood flowCardiac output stateNormal saline vehicleVenous blood flowMesenteric vasoconstrictionPortal pressureSplanchnic hypoperfusionVascular resistanceHepatic arterialEndothelin-1Liver protectionEffects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase
2002
Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*
Treggiari MM, Romand JA, Burgener D, Suter PM, Aneman A. Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*. Critical Care Medicine 2002, 30: 1334-1339. PMID: 12072691, DOI: 10.1097/00003246-200206000-00032.Peer-Reviewed Original ResearchConceptsMean arterial pressureArterial pressureCardiac outputRenal arteryEndotoxic shockPortal veinBlood flowPorcine modelPortal vein blood flowAdministration of norepinephrineEndotoxic shock modelSystemic oxygen extractionVein blood flowEnhanced cardiac outputLaser Doppler flowmetryRegional blood flowAcute endotoxic shock modelAcute interventional studyAnimal research laboratoryEndotoxemic controlsJejunal tonometryNorepinephrine dosageRenal perfusionAcute modelInterventional study