2009
Prolonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate
Rozet I, Tontisirin N, Vavilala MS, Treggiari MM, Lee LA, Lam AM. Prolonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate. Anesthesia & Analgesia 2009, 109: 1105-1110. PMID: 19641048, DOI: 10.1213/ane.0b013e3181b5a220.Peer-Reviewed Original ResearchConceptsPropofol groupVolatile anesthesiaBlood lossAnesthesia timeSpine surgeryElective spine surgeryHigh serum lactateIntraoperative hemodynamic variablesProlonged spine surgeryPropofol infusion syndromeUse of vasopressorsPropofol patientsVA casesASA gradeInfusion syndromeSerum lactateArterial lactatePropofol infusionProspective studyHemodynamic variablesVA patientsPropofol anesthesiaIntraoperative dataLactic acidosisBlood lactate
2008
Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase