2013
Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis
Mayer‐Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch‐Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, for the EPIC E. Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis. Pediatric Pulmonology 2013, 48: 943-953. PMID: 23818295, PMCID: PMC4059359, DOI: 10.1002/ppul.22693.Peer-Reviewed Original ResearchConceptsTobramycin inhalation solutionHistorical controlsCystic fibrosisTrial participantsCulture positivityPA recurrenceDifferent antibiotic regimensHistorical control cohortInitial eradication therapyIncidence of hospitalizationStandard of careAntibiotic regimensEradication therapyRespiratory symptomsStandard careHospitalization outcomesHospitalization ratesCare treatmentControl cohortInhalation solutionAntimicrobial therapyClinical trialsEpidemiologic studiesInfection controlEligibility criteria
2005
Factors Associated with Failure of Noninvasive Positive Pressure Ventilation in the Emergency Department
Merlani PG, Pasquina P, Granier JM, Treggiari M, Rutschmann O, Ricou B. Factors Associated with Failure of Noninvasive Positive Pressure Ventilation in the Emergency Department. Academic Emergency Medicine 2005, 12: 1206-1215. PMID: 16293895, DOI: 10.1197/j.aem.2005.07.018.Peer-Reviewed Original ResearchMeSH KeywordsAgedEmergency Service, HospitalFemaleHospitalizationHumansIntubation, IntratrachealMaleMultivariate AnalysisOutcome and Process Assessment, Health CarePositive-Pressure RespirationPulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk FactorsSensitivity and SpecificitySurvival AnalysisSwitzerlandTreatment FailureConceptsNoninvasive positive pressure ventilationFailure of NPPVAcute respiratory failurePositive pressure ventilationEmergency departmentRespiratory rateRespiratory failurePressure ventilationEndotracheal intubationNPPV failureGlasgow Coma Scale scoreSubsequent endotracheal intubationNegative predictive valueED admissionInstitutional protocolFactors AssociatedPatientsPredictive valueScale scoreMultivariate analysisIntubationVentilationFailureHoursDepartment