2014
Characterization of Cardiac Dysfunction in Sepsis
Zaky A, Deem S, Bendjelid K, Treggiari MM. Characterization of Cardiac Dysfunction in Sepsis. Shock 2014, 41: 12-24. PMID: 24351526, DOI: 10.1097/shk.0000000000000065.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCardiomyopathiesCoronary CirculationDisease Models, AnimalEndothelium, VascularHumansMyocardial ContractionShock, SepticUltrasonographyConceptsSepsis-induced cardiomyopathyIntrinsic contractile functionContractile functionIntrinsic myocardial dysfunctionIntrinsic myocardial functionGlobal ventricular performanceCommon morbid conditionSevere sepsisSeptic shockCardiac dysfunctionHemodynamic assessmentMyocardial dysfunctionCardiac outputPeripheral circulationVentricular performanceAdditional potential mechanismMyocardial functionMorbid conditionsClinical characterizationCurrent evidenceHeart functionPhysiologic mechanismsPhysiopathological pathwaysAnimal modelsCellular signaling mechanisms
2008
Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase