2024
Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patients
2021
Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaSevere COVID-19Convalescent plasmaPlasma recipientsHospital mortalityUnexposed cohortCCP administrationSevere COVID-19 infectionPropensity score-matched analysisCOVID-19Limited therapeutic optionsCOVID-19 infectionCoronavirus disease 2019CCP recipientsHospital stayPrimary endpointSecondary endpointsHospital daysHospital dischargeEarly administrationComplete followMechanical ventilationTherapeutic optionsClinical differencesSevere disease
2013
Etomidate, Adrenal Function, and Mortality in Critically Ill Patients
Sunshine JE, Deem S, Weiss NS, Yanez ND, Daniel S, Keech K, Brown M, Treggiari MM. Etomidate, Adrenal Function, and Mortality in Critically Ill Patients. Respiratory Care 2013, 58: 639-646. PMID: 22906838, PMCID: PMC4126750, DOI: 10.4187/respcare.01956.Peer-Reviewed Original ResearchConceptsCritical illness-related corticosteroid insufficiencyIll patientsCorticosteroid insufficiencyHospital mortalityAdrenal functionInduction agentAdrenal function testingPrevious randomized studyRole of etomidateRetrospective cohort studyBaseline illness severityRisk of deathAlternative induction agentHigh-risk populationRisk of mortalitySmall randomized trialsAcademic medical centerNumber of deathsEtomidate administrationEtomidate exposureAdjusted riskCohort studySecondary outcomesOverall mortalityPrimary outcome
2012
Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults
Menon N, Joffe AM, Deem S, Yanez ND, Grabinsky A, Dagal AH, Daniel S, Treggiari MM. Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults. Respiratory Care 2012, 57: 1555-1563. PMID: 22324979, DOI: 10.4187/respcare.01617.Peer-Reviewed Original ResearchConceptsDifficult airwayHigh mortalityHospital stayAdmission severity scoresIll adult patientsComplications of intubationAirway management techniquesHospital mortalityInitial intubationMedian ICURespiratory failureTracheal extubationAdult patientsBaseline characteristicsCohort studyIll adultsIll patientsTracheal reintubationDifficult intubationSeverity scoreSubsequent intubationRisk factorsPatient costsReintubationRelative odds
2011
The association between fluid balance and outcomes after subarachnoid hemorrhage
Martini RP, Deem S, Brown M, Souter MJ, Yanez ND, Daniel S, Treggiari MM. The association between fluid balance and outcomes after subarachnoid hemorrhage. Neurocritical Care 2011, 17: 191-198. PMID: 21688008, DOI: 10.1007/s12028-011-9573-0.Peer-Reviewed Original ResearchConceptsPositive fluid balanceICU day 3Negative fluid balanceFluid balanceNew strokeSubarachnoid hemorrhageDay 3Early fluid balanceLevel 1 traumaCumulative fluid balanceWorse clinical presentationMultivariable logistic regressionLess urine outputHunt-Hess scoreGreater resource useTCD vasospasmHospital deathHospital mortalityICU admissionTroponin elevationAdmission GCSHospital courseHospital lengthAdult patientsPrimary outcomeIntraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury
Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD. Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. Journal Of Critical Care 2011, 26: 144-151. PMID: 20869200, DOI: 10.1016/j.jcrc.2010.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAdolescentAdultAgedAged, 80 and overAPACHECritical IllnessFemaleGuideline AdherenceHospital MortalityHumansInjury Severity ScoreIntraoperative PeriodLength of StayMaleMiddle AgedPositive-Pressure RespirationPractice Guidelines as TopicRetrospective StudiesRisk FactorsTidal VolumeYoung AdultConceptsAcute respiratory distress syndromeAcute lung injuryALI/acute respiratory distress syndromeLTV ventilationLung injuryClinical outcomesLow tidal volume ventilation strategyALI/ARDS diagnosisLow tidal volume ventilationVolume ventilation strategyRespiratory distress syndromeTidal volume ventilationARDS diagnosisHospital mortalityIntraoperative adherenceHospital lengthSecondary outcomesSurgical patientsDistress syndromeIll patientsVolume ventilationImproved oxygenationPatient outcomesRetrospective analysisMAIN OUTCOME
2009
Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.
Martini RP, Deem S, Yanez ND, Chesnut RM, Weiss NS, Daniel S, Souter M, Treggiari MM. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. Journal Of Neurosurgery 2009, 111: 644-9. PMID: 19392603, DOI: 10.3171/2009.2.jns08998.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCohort StudiesFemaleHealth ResourcesHospital CostsHospital MortalityHumansIntracranial PressureLength of StayMaleMiddle AgedMonitoring, PhysiologicOxygenPrognosisRegression AnalysisRespiration, ArtificialRetrospective StudiesTrauma Severity IndicesTreatment OutcomeConceptsBrain tissue oxygen monitoringHospital mortality rateTissue oxygen monitoringTraumatic brain injurySevere traumatic brain injuryMortality rateBrain injuryHospital lengthNeurological outcomeHospital dischargeClinical managementICP monitoringMedian hospital lengthWorse neurological outcomeHospital resource utilizationOxygen monitoringMain outcome measuresFunctional Independence ScoreIntracranial pressure monitoringSeverity of injuryBaseline characteristicsCohort studyPatient ageMore patientsOsmotic therapy
2008
Intensive insulin therapy and mortality in critically ill patients
Treggiari MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA. Intensive insulin therapy and mortality in critically ill patients. Critical Care 2008, 12: r29. PMID: 18312617, PMCID: PMC2374630, DOI: 10.1186/cc6807.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCritical CareDose-Response Relationship, DrugFemaleGlycemic IndexHospital MortalityHumansHypoglycemiaHypoglycemic AgentsInsulinIntensive Care UnitsLength of StayMaleMiddle AgedMultiple Organ FailureRandomized Controlled Trials as TopicRegression AnalysisSeverity of Illness IndexTrauma CentersConceptsIntensive care unitHospital mortalityIll patientsSequential Organ Failure Assessment scoreOrgan Failure Assessment scorePost-cardiac surgery patientsLevel 1 trauma centerExcess hospital mortalityAdjusted hospital mortalityOccurrence of hypoglycemiaTight glycemic controlMain study endpointMultivariable regression analysisPeriod IIICU lengthPeriod IIICohort studyInsulin therapySurgery patientsGlycemic controlOrgan dysfunctionStudy endpointCare unitTrauma centerStudy population
2007
Effect of Intensive Care Unit Organizational Model and Structure on Outcomes in Patients with Acute Lung Injury
Treggiari MM, Martin DP, Yanez ND, Caldwell E, Hudson LD, Rubenfeld GD. Effect of Intensive Care Unit Organizational Model and Structure on Outcomes in Patients with Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2007, 176: 685-690. PMID: 17556721, PMCID: PMC1994237, DOI: 10.1164/rccm.200701-165oc.Peer-Reviewed Original ResearchConceptsAcute lung injuryClosed ICUOpen ICUHospital mortalityLung injuryData support recommendationsPopulation-based cohortPatient care practicesComplete survey dataAdult ICUsCohort studyImproved mortalityIll patientsIntensive careMain endpointPatient mortalityPotential confoundersHigher physicianICUICU structurePatient transferPatientsCare practicesSelf-administered mail questionnaireNurse availability