Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade
ÅNEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta Anaesthesiologica Scandinavica 2008, 53: 203-209. PMID: 19094177, DOI: 10.1111/j.1399-6576.2008.01834.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCardiac Output, LowCardiac TamponadeDrug Evaluation, PreclinicalEndothelin Receptor AntagonistsEndothelin-1FemaleLactatesLiver CirculationMaleModels, AnimalOxygenOxygen ConsumptionPyridinesSplanchnic CirculationSus scrofaTetrazolesVascular ResistanceVasoconstrictionConceptsLaser Doppler flowMesenteric oxygen deliveryLow CO stateBaseline valuesCardiac tamponadeOxygen deliveryBlood flowPorcine modelPortal venous blood flowHepatic artery blood flowLow cardiac output stateET-1 blockadeMesenteric oxygen extractionMesenteric vascular resistanceArtery blood flowCardiac output stateNormal saline vehicleVenous blood flowMesenteric vasoconstrictionPortal pressureSplanchnic hypoperfusionVascular resistanceHepatic arterialEndothelin-1Liver protection