2021
Factor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial
Sera VA, Stevens AE, Song HK, Rodriguez VM, Tibayan FA, Treggiari MM. Factor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial. Pilot And Feasibility Studies 2021, 7: 137. PMID: 34215339, PMCID: PMC8252226, DOI: 10.1186/s40814-021-00873-5.Peer-Reviewed Original ResearchFactor Eight Inhibitor Bypassing ActivityCardiac surgeryPilot trialTransfusion requirementsRescue therapyLarge trialsProtocol adherenceBlood productsHigh-risk cardiac surgeryProthrombin complex concentrate administrationPlacebo-controlled pilot trialFactor VIII inhibitor bypass activityLarge pivotal trialsReduction of transfusionBlood product transfusionEnd of CPBTertiary referral hospitalHypothermic circulatory arrestTermination of CPBPost-cardiopulmonary bypassProthrombin complex concentrateBlinded administrationProduct transfusionResultsTwenty patientsStudy drug
2014
Assessment of Circulating Blood Volume with Fluid Administration Targeting Euvolemia or Hypervolemia
Joffe AM, Khandelwal N, Hallman MR, Treggiari MM. Assessment of Circulating Blood Volume with Fluid Administration Targeting Euvolemia or Hypervolemia. Neurocritical Care 2014, 22: 82-88. PMID: 25142828, DOI: 10.1007/s12028-014-9993-8.Peer-Reviewed Original ResearchConceptsSubgroup of patientsBlood volumeHV groupDay 5Fluid administrationFluid balanceDelayed ischemic neurologic deficitsCrystalloid fluid administrationIschemic neurologic deficitCumulative fluid balanceML/Higher fluid balanceT-testStudent's t-testProphylactic hypervolemiaICU admissionICU stayResultsTwenty patientsNeurologic deficitsCerebral vasospasmClinical trialsHypervolemiaNormovolemiaBVA-100Concurrent group