2008
Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade
ÅNEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta Anaesthesiologica Scandinavica 2008, 53: 203-209. PMID: 19094177, DOI: 10.1111/j.1399-6576.2008.01834.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCardiac Output, LowCardiac TamponadeDrug Evaluation, PreclinicalEndothelin Receptor AntagonistsEndothelin-1FemaleLactatesLiver CirculationMaleModels, AnimalOxygenOxygen ConsumptionPyridinesSplanchnic CirculationSus scrofaTetrazolesVascular ResistanceVasoconstrictionConceptsLaser Doppler flowMesenteric oxygen deliveryLow CO stateBaseline valuesCardiac tamponadeOxygen deliveryBlood flowPorcine modelPortal venous blood flowHepatic artery blood flowLow cardiac output stateET-1 blockadeMesenteric oxygen extractionMesenteric vascular resistanceArtery blood flowCardiac output stateNormal saline vehicleVenous blood flowMesenteric vasoconstrictionPortal pressureSplanchnic hypoperfusionVascular resistanceHepatic arterialEndothelin-1Liver protection
2002
Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*
Treggiari MM, Romand JA, Burgener D, Suter PM, Aneman A. Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*. Critical Care Medicine 2002, 30: 1334-1339. PMID: 12072691, DOI: 10.1097/00003246-200206000-00032.Peer-Reviewed Original ResearchConceptsMean arterial pressureArterial pressureCardiac outputRenal arteryEndotoxic shockPortal veinBlood flowPorcine modelPortal vein blood flowAdministration of norepinephrineEndotoxic shock modelSystemic oxygen extractionVein blood flowEnhanced cardiac outputLaser Doppler flowmetryRegional blood flowAcute endotoxic shock modelAcute interventional studyAnimal research laboratoryEndotoxemic controlsJejunal tonometryNorepinephrine dosageRenal perfusionAcute modelInterventional study