2024
Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemiaEarly Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Kelly-Hedrick M, Liu S, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Journal Of Intensive Care Medicine 2024, 39: 875-882. PMID: 38449336, DOI: 10.1177/08850666241236724.Peer-Reviewed Original ResearchAssociated with hospital mortalityRetrospective cohort studyLength of stayModerate-severe TBITraumatic brain injuryCohort studyIntensive care unitBeta-blocker classHospital mortalityUtilization patternsClaims-based datasetHospital length of stayIll patientsCritically ill patientsIntensive care unit length of stayBrain injuryBeta-blockersHealthcare databasesInclusion criteriaSecondary outcomesPremier Healthcare DatabasePrimary outcomeVasopressor utilizationIntensive care unit stayHospital
2021
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2020
Randomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients
Harris WM, Treggiari MM, LeBlanc A, Giacomuzzi C, You JJ, Muralidaran A, Shen I. Randomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 452-458. PMID: 32645767, DOI: 10.1177/2150135120923627.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgery patientsAcute normovolemic hemodilutionCardiac surgery patientsSecondary end pointsSurgery patientsEnd pointPostoperative outcomesUsual careBlood transfusionCardiac surgeryNormovolemic hemodilutionHeart surgeryBlood productsPilot trialPediatric heart surgery patientsMarkers of morbidityAllogenic blood transfusionPrimary end pointHeart surgery patientsLong-term morbidityBlood conservation strategiesWorse postoperative outcomesPediatric heart surgeryIntensive care unitBlood component therapy
2018
Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit
Fink RJ, Young A, Yanez ND, Hom M, Mai J, Treggiari M, Merkel M. Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2018, 38: 1241-1249. PMID: 30403299, DOI: 10.1002/phar.2195.Peer-Reviewed Original ResearchConceptsIntensive care unitPostcardiac surgery patientsCardiovascular intensive care unitFluid resuscitation strategySurgery patientsCare unitCohort studySecondary outcomesAlbumin useResuscitation strategiesPost interventionAfter cohort studyPost-intervention periodPost-intervention time periodsNet cost savingsIntervention time periodFluid resuscitationClinical parametersAlbumin reductionEvidence-based practiceAdmission ordersIntervention periodLactated Ringer'sPatientsEducational interventionRight Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery
Yockelson SR, Heitner SB, Click S, Geleto G, Treggiari MM, Hutchens MP. Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 725-731. PMID: 30316640, PMCID: PMC6379134, DOI: 10.1053/j.jvca.2018.09.012.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRV systolic pressureSpeckle tracking echocardiographyCardiac surgeryAKI groupTransthoracic echocardiogramKidney injurySystolic pressureMyocardial performanceElevated RV systolic pressureRight ventricular myocardial performanceCardiovascular intensive care unitRetrospective observational cohort studyRV myocardial performancePreoperative serum creatinineCardiac surgery patientsCentral venous pressureObservational cohort studyVentricular systolic performanceSerum creatinine valuesVentricular myocardial performanceBody mass indexIntensive care unitIntravascular volume statusSpeckle-tracking analysis
2015
Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review
Zaky A, Zeliadt SB, Treggiari MM. Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review. Anaesthesia And Intensive Care 2015, 43: 23-33. PMID: 25579286, DOI: 10.1177/0310057x1504300105.Peer-Reviewed Original ResearchConceptsPatient-level interventionsIntensive care unitMDR-GNBCare unitSystematic reviewMultidrug-resistant Gram-negative bacterial infectionsSelective digestive decontaminationComparative interventional studyGram-negative bacterial infectionsInfection control effortsResistant Gram-negative bacteriaRate of infectionPrevention of colonisationDigestive decontaminationInterventional trialsIll patientsInterventional studyAnalysed trialsControl groupBacterial infectionsInfectionInterventionTrialsSignificant reductionScience databases
2014
Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals
Khandelwal N, Dale CR, Benkeser DC, Joffe AM, Yanez ND, Treggiari MM. Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 29: 551-559. PMID: 25802193, PMCID: PMC4427545, DOI: 10.1053/j.jvca.2014.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAirway ExtubationAirway ManagementCardiac Surgical ProceduresCohort StudiesCoronary Artery BypassCritical CareDatabases, FactualFemaleHealth SurveysHumansIntubation, IntratrachealMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic FactorsTreatment FailureTreatment OutcomeWashingtonConceptsIntensive care unitCardiac surgeryWashington State hospitalsNonfederal hospitalsState HospitalAcute care daysGreater hospital volumeOdds of reintubationCoronary artery bypassRetrospective cohort studyPatient-level characteristicsMultivariate logistic regressionSignificant heterogeneityValvular surgeryArtery bypassCohort studyHospital factorsHospital volumePatient characteristicsTracheal reintubationCare unitProcedure characteristicsHospital characteristicsCare daysReintubationImproved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation
Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM. Improved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation. Annals Of The American Thoracic Society 2014, 11: 367-374. PMID: 24597599, PMCID: PMC4028734, DOI: 10.1513/annalsats.201306-210oc.Peer-Reviewed Original ResearchConceptsCAM-ICU assessmentsIntensive care unitMechanical ventilationMedian durationICU stayBenzodiazepine doseSedation protocolPatient assessmentBaseline cohortTrauma-surgical intensive care unitConfusion Assessment Method-ICURichmond Agitation-Sedation Scale scorePrespecified secondary endpointSedation Scale scoreDays of deliriumImproved patient outcomesMultivariable linear regressionBenzodiazepine dosingBenzodiazepine exposureDelirium protocolHospital mortalityPneumonia ratesProtocol cohortRASS assessmentsImproved analgesia
2013
Validity of Exchangeable Solute Balance as a Measure of Blood Volume in Neurologically Injured Adults
Joffe AM, Healey L, Khandelwal N, Hallman MR, Van Cleve W, Treggiari MM. Validity of Exchangeable Solute Balance as a Measure of Blood Volume in Neurologically Injured Adults. Neurocritical Care 2013, 21: 102-107. PMID: 24057812, DOI: 10.1007/s12028-013-9915-1.Peer-Reviewed Original ResearchConceptsBlood volumeFluid balanceNeuroscience intensive care unitBV measurementsExtracellular fluidConsecutive adult patientsLarge academic medical centerIntensive care unitAcademic medical centerBV testResults55 patientsAdult patientsRoutine careCare unitTotal body waterCapillary leakActual blood volumeMedical CenterRobust variance estimationBVA-100MethodsThe UniversityAlbumin injectionNumber of daysPatientsBody water
2009
Randomized trial of light versus deep sedation on mental health after critical illness*
Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, Heidegger CP, Weiss NS. Randomized trial of light versus deep sedation on mental health after critical illness*. Critical Care Medicine 2009, 37: 2527-2534. PMID: 19602975, DOI: 10.1097/ccm.0b013e3181a5689f.Peer-Reviewed Original ResearchConceptsDeep sedation groupIntensive care unit dischargeIntensive care unitPosttraumatic stress disorderPatients' mental healthSedation groupDeep sedationCare unitMechanical ventilationStress disorderMental healthIntensive care unit staySingle tertiary care centerLight sedation groupDuration of ventilationTertiary care centerUnit dischargeOccurrence of anxietyTrials of lightPosttraumatic stress disorder (PTSD) symptomsUnit stayAdult patientsAdverse eventsCritical illnessPrimary outcome
2008
The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury
Cooke CR, Watkins TR, Kahn JM, Treggiari MM, Caldwell E, Hudson LD, Rubenfeld GD. The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Critical Care 2008, 12: r134. PMID: 18980682, PMCID: PMC2646342, DOI: 10.1186/cc7105.Peer-Reviewed Original ResearchConceptsClosed intensive care unitAcute lung injuryIntensive care unitLung injuryCare unitTidal volumeProspective population-based cohortLow VTOpen intensive care unitIntensivist physician staffingPopulation-based cohortProcess of careHospital mortalityVentilatory practicesImproved mortalityIntensive carePhysician staffingPatient outcomesMean VTPatientsDay threeSecondary analysisPotential patientsHigh VTKing CountyExtending the use of inhaled anesthetics beyond the operating room: a giant snake creeping into the intensive care unit.
Treggiari MM. Extending the use of inhaled anesthetics beyond the operating room: a giant snake creeping into the intensive care unit. Respiratory Care 2008, 53: 1280-2. PMID: 18811986.Peer-Reviewed Original ResearchIntensive insulin therapy and mortality in critically ill patients
Treggiari MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA. Intensive insulin therapy and mortality in critically ill patients. Critical Care 2008, 12: r29. PMID: 18312617, PMCID: PMC2374630, DOI: 10.1186/cc6807.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCritical CareDose-Response Relationship, DrugFemaleGlycemic IndexHospital MortalityHumansHypoglycemiaHypoglycemic AgentsInsulinIntensive Care UnitsLength of StayMaleMiddle AgedMultiple Organ FailureRandomized Controlled Trials as TopicRegression AnalysisSeverity of Illness IndexTrauma CentersConceptsIntensive care unitHospital mortalityIll patientsSequential Organ Failure Assessment scoreOrgan Failure Assessment scorePost-cardiac surgery patientsLevel 1 trauma centerExcess hospital mortalityAdjusted hospital mortalityOccurrence of hypoglycemiaTight glycemic controlMain study endpointMultivariable regression analysisPeriod IIICU lengthPeriod IIICohort studyInsulin therapySurgery patientsGlycemic controlOrgan dysfunctionStudy endpointCare unitTrauma centerStudy population
2006
Risk factors for reperfusion injury after lung transplantation
Cottini SR, Lerch N, de Perrot M, Treggiari MM, Spiliopoulos A, Nicod L, Ricou B. Risk factors for reperfusion injury after lung transplantation. Intensive Care Medicine 2006, 32: 557-563. PMID: 16520995, DOI: 10.1007/s00134-006-0096-7.Peer-Reviewed Original ResearchConceptsReperfusion injuryIntensive care unitPulmonary hypertensionLung transplantationHigher systolic pulmonary pressureSurgical intensive care unitDonor/recipient pairsSystolic pulmonary hypertensionSystolic pulmonary pressureAdministration of catecholaminesDifficult hemostasisSettingRetrospective studyICU mortalityPerioperative hemostasisPostoperative variablesPulmonary pressurePreoperative valuesCare unitMechanical ventilationUniversity HospitalDonor factorsEarly recognitionRisk factorsRecipient pairsRelative odds
2004
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*
Treggiari MM, Hudson LD, Martin DP, Weiss NS, Caldwell E, Rubenfeld G. Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*. Critical Care Medicine 2004, 32: 327-331. PMID: 14758144, DOI: 10.1097/01.ccm.0000108870.09693.42.Peer-Reviewed Original ResearchConceptsALI/acute respiratory distress syndromeAcute respiratory distress syndromeAcute lung injuryAcute Physiology ScoreRespiratory distress syndromeTrauma patientsHospital mortalityPhysiology ScoreLung injuryDistress syndromeSeverity scoreHospital costsTrauma severityAmerican-European Consensus Conference definitionPresence of ALIIntensive care unit admissionIntensive care unit stayIll trauma patientsCare unit admissionInjury Severity ScoreConsensus Conference definitionLevel I centersCrude relative riskIntensive care unitLength of stay