Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sinha S, Sparks H, Labit E, Robbins H, Gowing K, Jaffer A, Kutluberk E, Arora R, Raredon M, Cao L, Swanson S, Jiang P, Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam K, de Almeida L, Adam M, Niklason L, Potter S, Seifert A, Dufour A, Gabriel V, Rosin N, Stewart R, Muench G, McCorkell R, Matyas J, Biernaskie J. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell 2022, 185: 4717-4736.e25. PMID: 36493752, PMCID: PMC9888357, DOI: 10.1016/j.cell.2022.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCicatrixFetusFibroblastsHumansReindeerSkinSkin TransplantationWound HealingConceptsFibrotic scarSite-specific immune responseFull-thickness injurySkin fibroblastsWound healing outcomesInflammatory mediatorsImmunosuppressive phenotypeImmune resolutionLeukocyte recruitmentMyeloid infiltrationImmune responseHuman fetal fibroblastsHealing outcomesFibrotic phenotypeBack skinEctopic transplantationAdult humansSkin woundsScarSkinSkin repairPowerful comparative modelFibroblastsFetal fibroblastsRepair