Bioreactor technologies to support liver function in vitro
Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG. Bioreactor technologies to support liver function in vitro. Advanced Drug Delivery Reviews 2014, 69: 132-157. PMID: 24607703, PMCID: PMC4144187, DOI: 10.1016/j.addr.2014.02.011.Peer-Reviewed Original ResearchConceptsSmall molecule drugsNucleic acid therapyNew experimental modelPrediction of metabolismImmunologic homeostasisAcid therapyLiver functionDrug discoveryMolecule drugsLiver physiologyExperimental modelLong-term liver-specific functionDisease modelsDrug developmentMolecular therapeuticsTarget effectsTherapeuticsWide spectrumIndirect targetsPathophysiologyTherapyLiver-specific functions