2007
Two Trypanosome-Specific Proteins Are Essential Factors for 5S rRNA Abundance and Ribosomal Assembly in Trypanosoma brucei▿
Hellman KM, Ciganda M, Brown SV, Li J, Ruyechan W, Williams N. Two Trypanosome-Specific Proteins Are Essential Factors for 5S rRNA Abundance and Ribosomal Assembly in Trypanosoma brucei▿. MSphere 2007, 6: 1766-1772. PMID: 17715362, PMCID: PMC2043393, DOI: 10.1128/ec.00119-07.Peer-Reviewed Original ResearchConceptsRNAi cellsRRNA levelsNovel nuclear RNATrypanosome-specific proteinsRNA interference studiesN-terminal regionRibosome biogenesisOverall protein synthesisRibosomal assemblyRibosome activityP37 proteinRRNA abundanceAncient familyNuclear RNARibosomal subunitTrypanosoma bruceiT. bruceiCell shapeGrowth arrestWeight complexesRRNAAcid differencesProtein p34Protein synthesisP34
2003
Stage-specific translational efficiency and protein stability regulate the developmental expression of p37, an RNA binding protein from Trypanosoma brucei
Li J, Ruyechan WT, Williams N. Stage-specific translational efficiency and protein stability regulate the developmental expression of p37, an RNA binding protein from Trypanosoma brucei. Biochemical And Biophysical Research Communications 2003, 306: 918-923. PMID: 12821129, DOI: 10.1016/s0006-291x(03)01084-2.Peer-Reviewed Original ResearchConceptsProcyclic stageP37 proteinVivo metabolic labelingRNA binding proteinPost-translational levelDifferential stabilityCysteine protease activityProcyclic cellsSignificant homologyBloodstream cellsDevelopmental regulationNovel RNAProtein stabilityTrypanosoma bruceiTranslational efficiencyMetabolic labelingPredominant proteinDevelopmental expressionBinding proteinP37P34ProteinProtease activityRNACells