2024
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original Research
2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2009
Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
Wagshul M, McAllister J, Rashid S, Li J, Egnor M, Walker M, Yu M, Smith S, Zhang G, Chen J, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Experimental Neurology 2009, 218: 33-40. PMID: 19348801, DOI: 10.1016/j.expneurol.2009.03.034.Peer-Reviewed Original ResearchConceptsVentricular dilationAqueductal flowVentricular volumeInjection of kaolinNew experimental modelCSF pulsatilityClinical presentationMild ventriculomegalyVentricular sizeBasal cisternsChronic elevationAbnormal pulsationsCerebral aqueductHydrocephalic animalsEffective treatmentAdult ratsIntact controlsNormal levelsHydrocephalusExperimental modelT MRIRatsMonth periodVentriculomegalyDilation
2008
Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"
Djurić P, Benveniste H, Wagshul M, Henn F, Enikolopov G, Maletić-Savatić M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain". Science 2008, 321: 640-640. PMID: 26380846, PMCID: PMC4576718, DOI: 10.1126/science.1156889.Peer-Reviewed Original ResearchMetabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery
Maletić-Savatić M, Vingara L, Manganas L, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul M, Henn F, Krupp L, Enikolopov G, Benveniste H, Djurić P, Pelczer I. Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery. Cold Spring Harbor Symposia On Quantitative Biology 2008, 73: 389-401. PMID: 19022759, PMCID: PMC4037147, DOI: 10.1101/sqb.2008.73.021.Peer-Reviewed Original ResearchConceptsNeural stem/progenitor cellsFunctional insightsProgenitor cellsStem/progenitor cellsNeural progenitor cellsBiomarker discoveryGenome backgroundHuman neurological diseasesLive human brainSystems metabolomicsMammalian brainVivo analysisSpecific metabolitesMetabolomics techniquesMost neurological disordersLack of biomarkersEarly pathological processesProton magnetic resonance spectroscopyOrganismsMetabolomicsPathological processesHuman brainNPC biomarkersCellsLate therapy
2007
Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays
Anschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays. Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.Peer-Reviewed Original ResearchConceptsT2 signalCentral nervous system diseaseHigh T2 signalNervous system diseasesTesla magnetic resonance imagingFocal brain lesionsMagnetic resonance imagingBrain lesionsRadiosurgical approachRat brainSystem diseasesStereotactic radiosurgeryHigh-dose irradiationFuture treatmentLow dosesLesionsResonance imagingLow T1Dose irradiationBrainTreatmentPrecise targetsX-ray
2005
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy
Ma Y, Hof P, Grant S, Blackband S, Bennett R, Slatest L, McGuigan M, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience 2005, 135: 1203-1215. PMID: 16165303, DOI: 10.1016/j.neuroscience.2005.07.014.Peer-Reviewed Original Research
2001
Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study
McDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study. NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtrophyBrainBrain IschemiaBrain MappingCerebral VentriclesDisease Models, AnimalHippocampusImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, Neurologic MutantsMicroscopyNeurodegenerative DiseasesProsencephalonConceptsApoE-deficient miceModels of neurodegenerationPostischemic dayBrain atrophyMouse modelNeurodegenerative diseasesDorsal hippocampal volumeBrain volume changesMin of ischemiaHigh signal intensity areaTransgenic mouse modelProgression of pathologyCorresponding time pointsSignal intensity areaMagnetic resonance imagingHigh-resolution MRIT1-weighted MR imagingC57 miceDorsal hippocampusHippocampal volumeClinical conditionsIschemiaMRI studiesPredetermined protocolCognitive declineProgress in high field MRI at the University of Florida
Beck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida. Magnetic Resonance Materials In Physics, Biology And Medicine 2001, 13: 152-157. PMID: 11755090, PMCID: PMC3363288, DOI: 10.1007/bf02678590.Peer-Reviewed Original Research
2000
Magnetic Resonance Microscopy of the C57BL Mouse Brain
Benveniste H, Kim K, Zhang L, Johnson G. Magnetic Resonance Microscopy of the C57BL Mouse Brain. NeuroImage 2000, 11: 601-611. PMID: 10860789, DOI: 10.1006/nimg.2000.0567.Peer-Reviewed Original ResearchIn vivo magnetic resonance imaging of transgene expression
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E, Basilion J. In vivo magnetic resonance imaging of transgene expression. Nature Medicine 2000, 6: 351-354. PMID: 10700241, DOI: 10.1038/73219.Peer-Reviewed Original ResearchCerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1999
In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine
Benveniste H, Qui H, Hedlund L, Hüttemeier P, Steele S, Johnson G. In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine. Regional Anesthesia & Pain Medicine 1999, 24: 311-318. PMID: 10445769, DOI: 10.1016/s1098-7339(99)90104-9.Peer-Reviewed Original ResearchConceptsDiffusion-weighted magnetic resonance microscopyRat spinal cordSpinal cordHyperbaric 5Hyperbaric lidocaineNeurologic deficitsGroup 2Group 1White matterGray matterIrreversible neurologic deficitsPersistent neurologic deficitsSpinal cord ischemiaContinuous spinal anesthesiaPresence of ischemiaBlood-nerve barrierEffects of ischemiaWhite matter tractsCord ischemiaIntrathecal anesthesiaIntrathecal lidocaineSpinal anesthesiaSpinal catheterPathophysiologic mechanismsCardiac arrest
1998
Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons
Scotland P, Zhou D, Benveniste H, Bennett V. Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons. Journal Of Cell Biology 1998, 143: 1305-1315. PMID: 9832558, PMCID: PMC2133070, DOI: 10.1083/jcb.143.5.1305.Peer-Reviewed Original ResearchConceptsNervous systemOptic nervePyramidal tractCorpus callosumOptic nerve axonsPostnatal day 21Long fiber tractsPostnatal day 1Postnatal day 7Mouse nervous systemNervous system defectsL1 miceCell adhesion molecule L1Internal capsuleSpinal cordAdhesion molecule L1Extensive degenerationCell adhesion moleculeLateral columnDay 1Day 21Day 7Human patientsL1 mutationsDay 20Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson A. Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. DOI: 10.1097/00115550-199823060-00014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF ratsSpinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson G. Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. PMID: 9840856, DOI: 10.1016/s1098-7339(98)90087-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF rats
1997
Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study
Qiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study. Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryStroke volumeIpsilateral common carotid arteryReduced stroke volumeFocal ischemic lesionsCommon carotid arteryGlycine/NMDA antagonistsMCA occlusionCerebral arteryIschemic lesionsMultiple time pointsNMDA antagonistsCarotid arteryDrug treatmentRat brainGroup 2Group 1Control groupVivo studiesTime pointsZD9379ArteryOcclusionHoursTreatmentExtracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats
Shiraishi M, Kamiyama Y, Hüttemeier P, Benveniste H. Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats. Brain Research 1997, 759: 221-227. PMID: 9221940, DOI: 10.1016/s0006-8993(97)00258-8.Peer-Reviewed Original ResearchConceptsGlutamate levelsExtracellular glutamateAwake ratsMicrodialysis probeExtracellular striatal glutamateHalothane-anesthetized ratsNormal female ratsEffects of anesthesiaLower glutamate levelsTTX concentrationsStriatal glutamateBrain interstitialBrain metabolismDialysate dopamineFemale ratsSynaptic transmissionRat striatumMicrodialysis measurementsNeurotoxic potentialTetrodotoxinRatsNon-stimulated conditionsProbe implantationGlutamateAnesthesiaMagnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b
JOHNSON G, BENVENISTE H, ENGELHARDT R, QIU H, HEDLUND L. Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b. Annals Of The New York Academy Of Sciences 1997, 820: 139-148. PMID: 9237453, DOI: 10.1111/j.1749-6632.1997.tb46193.x.Peer-Reviewed Original Research
1996
A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy
Hall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy. NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.Peer-Reviewed Original Research