2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2009
Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
Wagshul M, McAllister J, Rashid S, Li J, Egnor M, Walker M, Yu M, Smith S, Zhang G, Chen J, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Experimental Neurology 2009, 218: 33-40. PMID: 19348801, DOI: 10.1016/j.expneurol.2009.03.034.Peer-Reviewed Original ResearchConceptsVentricular dilationAqueductal flowVentricular volumeInjection of kaolinNew experimental modelCSF pulsatilityClinical presentationMild ventriculomegalyVentricular sizeBasal cisternsChronic elevationAbnormal pulsationsCerebral aqueductHydrocephalic animalsEffective treatmentAdult ratsIntact controlsNormal levelsHydrocephalusExperimental modelT MRIRatsMonth periodVentriculomegalyDilation
2007
Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays
Anschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays. Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.Peer-Reviewed Original ResearchConceptsT2 signalCentral nervous system diseaseHigh T2 signalNervous system diseasesTesla magnetic resonance imagingFocal brain lesionsMagnetic resonance imagingBrain lesionsRadiosurgical approachRat brainSystem diseasesStereotactic radiosurgeryHigh-dose irradiationFuture treatmentLow dosesLesionsResonance imagingLow T1Dose irradiationBrainTreatmentPrecise targetsX-ray
2001
Progress in high field MRI at the University of Florida
Beck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida. Magnetic Resonance Materials In Physics, Biology And Medicine 2001, 13: 152-157. PMID: 11755090, PMCID: PMC3363288, DOI: 10.1007/bf02678590.Peer-Reviewed Original Research
2000
In vivo magnetic resonance imaging of transgene expression
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E, Basilion J. In vivo magnetic resonance imaging of transgene expression. Nature Medicine 2000, 6: 351-354. PMID: 10700241, DOI: 10.1038/73219.Peer-Reviewed Original ResearchCerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1999
In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine
Benveniste H, Qui H, Hedlund L, Hüttemeier P, Steele S, Johnson G. In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine. Regional Anesthesia & Pain Medicine 1999, 24: 311-318. PMID: 10445769, DOI: 10.1016/s1098-7339(99)90104-9.Peer-Reviewed Original ResearchConceptsDiffusion-weighted magnetic resonance microscopyRat spinal cordSpinal cordHyperbaric 5Hyperbaric lidocaineNeurologic deficitsGroup 2Group 1White matterGray matterIrreversible neurologic deficitsPersistent neurologic deficitsSpinal cord ischemiaContinuous spinal anesthesiaPresence of ischemiaBlood-nerve barrierEffects of ischemiaWhite matter tractsCord ischemiaIntrathecal anesthesiaIntrathecal lidocaineSpinal anesthesiaSpinal catheterPathophysiologic mechanismsCardiac arrest
1998
Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson A. Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. DOI: 10.1097/00115550-199823060-00014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF ratsSpinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy
Benveniste H, Qui H, Hedlund L, D'Ercole F, Johnson G. Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy. Regional Anesthesia & Pain Medicine 1998, 23: 589-599. PMID: 9840856, DOI: 10.1016/s1098-7339(98)90087-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCatheters, IndwellingCervical VertebraeColoring AgentsContrast MediaDiffusionEdemaEpidural SpaceFeasibility StudiesFemaleFollow-Up StudiesInjections, SpinalIschemiaLongitudinal StudiesLumbar VertebraeMagnetic Resonance ImagingMicroscopyNeurilemmaPeripheral Nervous System DiseasesRatsRats, Inbred F344Regional Blood FlowSpinal CordSpinal Cord DiseasesSpinal NervesConceptsIntrathecal catheterSpinal cordApparent diffusion coefficientCytotoxic edemaGroup 2Diffusion-weighted magnetic resonance microscopyGroup 3Cervical intrathecal catheterRat cervical spinal cordSpinal cord perfusionLumbar intrathecal cathetersCervical spinal cordPeripheral nerve studiesPresence of ischemiaNormal blood flowLumbar spine anatomyApparent diffusion coefficient (ADC) measurementsCord perfusionNerve studiesPlexus anatomySpinal nervesCervical spineIntrathecal spaceContrast studiesCDF rats
1997
Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study
Qiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study. Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryStroke volumeIpsilateral common carotid arteryReduced stroke volumeFocal ischemic lesionsCommon carotid arteryGlycine/NMDA antagonistsMCA occlusionCerebral arteryIschemic lesionsMultiple time pointsNMDA antagonistsCarotid arteryDrug treatmentRat brainGroup 2Group 1Control groupVivo studiesTime pointsZD9379ArteryOcclusionHoursTreatmentExtracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats
Shiraishi M, Kamiyama Y, Hüttemeier P, Benveniste H. Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats. Brain Research 1997, 759: 221-227. PMID: 9221940, DOI: 10.1016/s0006-8993(97)00258-8.Peer-Reviewed Original ResearchConceptsGlutamate levelsExtracellular glutamateAwake ratsMicrodialysis probeExtracellular striatal glutamateHalothane-anesthetized ratsNormal female ratsEffects of anesthesiaLower glutamate levelsTTX concentrationsStriatal glutamateBrain interstitialBrain metabolismDialysate dopamineFemale ratsSynaptic transmissionRat striatumMicrodialysis measurementsNeurotoxic potentialTetrodotoxinRatsNon-stimulated conditionsProbe implantationGlutamateAnesthesia
1996
A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy
Hall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy. NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.Peer-Reviewed Original Research
1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1993
Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats
Huttemeier P, Ritter E, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. American Journal Of Physiology 1993, 265: h767-h769. PMID: 8368378, DOI: 10.1152/ajpheart.1993.265.2.h767.Peer-Reviewed Original ResearchConceptsAcute circulatory changesCirculatory changesSurvival rateCalcitonin gene-related peptide concentrationsCalcitonin gene-related peptideMean blood pressureOverall survival rateGene-related peptideRegional blood flowEscherichia coli endotoxinClinical sepsisSevere hypotensionBlood pressureEndotoxic ratsCardiac functionCGRP antagonismColi endotoxinBlood flowUntreated animalsHypotensionTachycardiaSepsisRatsCGRPHCGRPInhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia
Zhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate concentrationNitric oxide synthase inhibitionCerebral glutamate concentrationsOxide synthase inhibitionGlobal brain ischemiaInhibition of NOSNitric oxide synthaseExtracellular glutamate releaseCerebral microdialysisBrain ischemiaForebrain ischemiaControl ratsGlobal ischemiaNOS inhibitorOxide synthaseSynthase inhibitionCarotid arteryBrain flowDialysis probeIschemiaDialysate concentrationsControl valuesRatsReperfusionMicrodialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolismHydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain
Simonson S, Zhang J, Canada A, Su Y, Benveniste H, Piantadosi C. Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 125-134. PMID: 8417001, DOI: 10.1038/jcbfm.1993.15.Peer-Reviewed Original ResearchConceptsInhibition of MAOMonoamine oxidaseRat brainMAO inhibitorsForebrain blood flowMin of ischemiaBrain reperfusionIschemia reperfusionCatecholamine concentrationsBlood flowForebrain homogenatesReperfusionIschemiaGlutathione peroxidaseGlutathione concentrationBiochemical indicationsThreefold increaseBrainInhibitorsInhibitionH2O2 productionSurvivalHydrogen peroxide productionCatalasePeroxide production
1992
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1991
MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow
Maki J, Benveniste H, Macfall J, Piantadosi C, Johnson G. MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow. Journal Of Magnetic Resonance Imaging 1991, 1: 673-681. PMID: 1823172, DOI: 10.1002/jmri.1880010609.Peer-Reviewed Original ResearchConceptsCerebral blood flowRat cerebral blood flowBlood flowArterial carbon dioxide pressureLaser Doppler flowmetry studyMR imaging studiesMagnetic resonance imaging techniquesRat brainLDF valuesCarbon dioxide pressureImaging studiesMR imagingTissue microcirculationImaging valuesPaCO2MicrocirculationQualitative pictureMotion sensitivityPresent studyCarbon dioxide-induced changeImaging techniquesFC techniqueRat motionsGradient coilsImagingDecreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose
Hilgier W, Benveniste H, Diemer N, Albrecht J. Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose. Acta Neurologica Scandinavica 1991, 83: 353-355. PMID: 1887755, DOI: 10.1111/j.1600-0404.1991.tb03961.x.Peer-Reviewed Original ResearchConceptsBrain regionsLocal cerebral metabolic rateCerebral metabolic rateDiscrete brain regionsHepatic encephalopathyParticular brain regionsCerebral cortexGlutamatergic neuronsGlutamatergic neurotransmissionMedulla oblongataAuditory cortexGlucose utilizationDeoxyglucose uptakeBioenergetic failureEnergy metabolismRatsCortexPossible linkMetabolic ratePossible contributionThioacetamideOblongataEncephalopathyHippocampusStriatum