Publications

Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Mandino F, Shen X, Desrosiers-Grégoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EMR. Mol Psychiatry. 2025 May; 2024 Oct 18. PMID: 39424929.
The story of pain in people with dementia: a rationale for digital measures.Patrascu M, Berge LI, Vahia IV, Marty B, Achterberg WP, Allore H, Fletcher RR, Husebo BS. BMC Med. 2025 Apr 17; 2025 Apr 17. PMID: 40247335.
The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Lorenz A, Sathe A, Zaras D, Yang Y, Durant A, Kim ME, Gao C, Newlin NR, Ramadass K, Kanakaraj P, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Shashikumar N, Pechman KR, Jackson TB, Workmeister AW, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Habes M, Wang D, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Bendlin B, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB. Alzheimers Dement. 2025 Apr. PMID: 40219815.
Prevalence of Reported Dietary Supplement Use in 2019 Older Adult (≥ 55 Years) National Alzheimer's Coordinating Center Participants With Normal Cognition, Mild Cognitive Impairment or Dementia.Sandoval KE. J Hum Nutr Diet. 2025 Apr. PMID: 40170292.
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.Bateman RJ, Li Y, McDade EM, Llibre-Guerra JJ, Clifford DB, Atri A, Mills SL, Santacruz AM, Wang G, Supnet C, Benzinger TLS, Gordon BA, Ibanez L, Klein G, Baudler M, Doody RS, Delmar P, Kerchner GA, Bittner T, Wojtowicz J, Bonni A, Fontoura P, Hofmann C, Kulic L, Hassenstab J, Aschenbrenner AJ, Perrin RJ, Cruchaga C, Renton AE, Xiong C, Goate AA, Morris JC, Holtzman DM, Snider BJ, Mummery C, Brooks WS, Wallon D, Berman SB, Roberson E, Masters CL, Galasko DR, Jayadev S, Sanchez-Valle R, Pariente J, Kinsella J, van Dyck CH, Gauthier S, Hsiung GR, Masellis M, Dubois B, Honig LS, Jack CR, Daniels A, Aguillón D, Allegri R, Chhatwal J, Day G, Fox NC, Huey E, Ikeuchi T, Jucker M, Lee JH, Levey AI, Levin J, Lopera F, Roh J, Rosa-Neto P, Schofield PR. Lancet Neurol. 2025 Apr. PMID: 40120616.
Absence of care among community-dwelling older adults with dementia and functional limitations.Lin Z, Qian Y, Gill TM, Hou X, Allore H, Chen S, Chen X. Nat Aging. 2025 Apr; 2025 Mar 17. PMID: 40097773.
The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease.Zeiss CJ, Huttner A, Nairn AC, Arnsten A, Datta D, Strittmatter SM, Wyk BV, Duque A. J Alzheimers Dis. 2025 Apr; 2025 Mar 17. PMID: 40095666.
Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias.Delaney SW, Stegmuller A, Mork D, Mock L, Bell ML, Gill TM, Braun D, Zanobetti A. JAMA Intern Med. 2025 Apr 1. PMID: 39899291.
Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning.Zheng X, Worhunsky P, Liu Q, Guo X, Chen X, Sun H, Zhang J, Toyonaga T, Mecca AP, O'Dell RS, van Dyck CH, Angarita GA, Cosgrove K, D'Souza D, Matuskey D, Esterlis I, Carson RE, Radhakrishnan R, Liu C. EJNMMI Phys. 2025 Mar 31; 2025 Mar 31. PMID: 40163154.
AI-driven fusion of neurological work-up for assessment of biological Alzheimer's disease.Jasodanand VH, Kowshik SS, Puducheri S, Romano MF, Xu L, Au R, Kolachalama VB. medRxiv. 2025 Mar 17; 2025 Mar 17. PMID: 40166530.
Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers.de Geus MB, Wu CY, Dodge H, Leslie SN, Wang W, Lam TT, Kahle KT, Chan D, Kivisäkk P, Nairn AC, Arnold SE, Carlyle BC. Neurology. 2025 Mar 11; 2025 Feb 14. PMID: 39951680.
Motor symptoms in autopsy-confirmed Alzheimer's disease increase the risk of progression to severe cognitive impairment.Shaw JS, Huang PC, Rosenberg PB, Peters ME. Alzheimers Dement. 2025 Mar. PMID: 40145251.
Marital status and risk of dementia over 18 years: Surprising findings from the National Alzheimer's Coordinating Center.Karakose S, Luchetti M, Stephan Y, Sutin AR, Terracciano A. Alzheimers Dement. 2025 Mar. PMID: 40110684.
The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center.Hayes CA, Young CB, Abdelnour C, Reeves A, Odden MC, Nirschl J, Crane PK, Poston KL, Mormino EC, Younes K. Alzheimers Dement. 2025 Mar. PMID: 40110658.
Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease.Mansel C, Mazzotti DR, Townley R, Sardiu ME, Swerdlow RH, Honea RA, Veatch OJ. Alzheimers Dement. 2025 Mar. PMID: 40110639.
Correlation between changes in apathy and cognition in Alzheimer's disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).Sankhe K, Tumati S, Perin J, Rivet L, Vieira D, Rosenberg PB, Herrmann N, Shade D, Lerner AJ, Padala PR, Brawman-Mintzer O, van Dyck CH, Porsteinsson AP, Craft S, Levey AI, Mintzer J, Lanctôt KL. Int Psychogeriatr. 2025 Mar; 2024 Dec 4. PMID: 40086910.
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease.Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo PL, Tong L, Qin S, Fuentes LA, Pinheiro-de-Sousa I, Huynh T, Sun L, Mansuri MS, Tian Z, Gan HR, Braker A, Trinh HK, Huttner A, Lam TT, Petsalaki E, Brennand KJ, Nairn AC, Grutzendler J. Nat Aging. 2025 Mar; 2025 Mar 10. PMID: 40065072.
Burden and care time for dementia caregivers in the LIVE@Home.Path trial.Berge LI, Angeles RC, Gedde MH, Fæø SE, Mannseth J, Vislapuu M, Søyland Puaschitz NG, Hillestad E, Aarsland D, Achterberg WP, Allore H, Ballard C, Li F, Selbæk G, Vahia IV, Husebo BS. Alzheimers Dement. 2025 Mar. PMID: 40042468.
Regularization by Neural Style Transfer for MRI Field-Transfer Reconstruction with Limited Data.Shen G, Zhu Y, Li M, McNaughton R, Jara H, Andersson SB, Farris CW, Anderson S, Zhang X. ArXiv. 2025 Feb 19; 2025 Feb 19. PMID: 40034133.
Explainable artificial intelligence for neuroimaging-based dementia diagnosis and prognosis.Martin SA, Zhao A, Qu J, Imms P, Irimia A, Barkhof F, Cole JH. medRxiv. 2025 Feb 14; 2025 Feb 14. PMID: 39867413.
Amyloid-β predominant Alzheimer's disease neuropathologic change.Kovacs GG, Katsumata Y, Wu X, Aung KZ, Fardo DW, Forrest SL, Nelson PT. Brain. 2025 Feb 3. PMID: 39417691.
The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Ramanan S, Akarca D, Henderson SK, Rouse MA, Allinson K, Patterson K, Rowe JB, Lambon Ralph MA. Brain. 2025 Feb 3. PMID: 39018014.
Examining multimorbidity contributors to dementia over time.Klee M, Markwardt S, Elman MR, Han L, Leist AK, Allore H, Quiñones A. Alzheimers Dement. 2025 Feb. PMID: 39988573.
Associations between lifelong cognitive reserve, Alzheimer's disease-related plasma biomarkers, and cognitive function in dementia-free older adults: A population-based study.Han X, Li Y, Wang J, Liu X, Zhang Y, Dong Q, Song Y, Cong L, Zhang Q, Tang S, Song L, Hou T, Wang Y, Du Y, Qiu C. J Alzheimers Dis. 2025 Feb; 2025 Jan 10. PMID: 39791378.
The etiology and prevention of early-stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques.Datta D, Arnsten AFT. Alzheimers Dement. 2025 Feb; 2025 Jan 8. PMID: 39776253.
Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers.Kulminski AM, Jain-Washburn E, Nazarian A, Wilkins HM, Veatch O, Swerdlow RH, Honea RA. Alzheimers Dement. 2025 Feb; 2024 Dec 23. PMID: 39713891.
Life satisfaction and risk of dementia over 18 years: an analysis of the National Alzheimer's Coordinating Center dataset.Karakose S, Luchetti M, Stephan Y, Sutin AR, Terracciano A. Geroscience. 2025 Feb; 2024 Nov 28. PMID: 39607591.
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.Huber HF, Ainsworth HC, Quillen EE, Salmon A, Ross C, Azhar AD, Bales K, Basso MA, Coleman K, Colman R, Darusman HS, Hopkins W, Hotchkiss CE, Jorgensen MJ, Kavanagh K, Li C, Mattison JA, Nathanielsz PW, Saputro S, Scorpio DG, Sosa PM, Vallender EJ, Wang Y, Zeiss CJ, Shively CA, Cox LA. Geroscience. 2025 Feb; 2024 Nov 25. PMID: 39585646.
Association of Seizure Control with Mortality, Cognition, and Function in People With Dementia.Zawar I, Quigg M, Ghosal S, Punia V, Calle-Lopez Y, Manning C, Kapur J. Ann Neurol. 2025 Feb; 2024 Oct 30. PMID: 39475168.
Neuroanatomical and clinical factors predicting future cognitive impairment.Imms P, Chaudhari NN, Chowdhury NF, Wang H, Yu X, Amgalan A, Irimia A. Geroscience. 2025 Feb; 2024 Aug 17. PMID: 39153054.
Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease.Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins JE. Nat Commun. 2025 Jan 28; 2025 Jan 28. PMID: 39875385.
Association of Alzheimer's and Lewy body disease pathology with basal forebrain volume and cognitive impairment.Schumacher J, Teipel S, Storch A. Alzheimers Res Ther. 2025 Jan 27; 2025 Jan 27. PMID: 39865328.
LD-informed deep learning for Alzheimer's gene loci detection using WGS data.Jo T, Bice P, Nho K, Saykin AJ. Alzheimers Dement (N Y). 2025 Jan-Mar; 2025 Jan 16. PMID: 39822590.
Improving estimation efficiency for survival data analysis by integrating a coarsened time-to-event outcome from an external study.Deng D, Zhang L, Feng H, Chinchilli VM, Chen C, Wang M. Biometrics. 2025 Jan 7. PMID: 39835592.
Evaluating the association of APOE genotype and cognitive resilience in SuperAgers.Durant A, Mukherjee S, Lee ML, Choi SE, Scollard P, Klinedinst BS, Trittschuh EH, Mez J, Farrer LA, Gifford KA, Cruchaga C, Hassenstab J, Naj AC, Wang LS, Johnson SC, Engelman CD, Kukull WA, Keene CD, Saykin AJ, Cuccaro ML, Kunkle BW, Pericak-Vance MA, Martin ER, Bennett DA, Barnes LL, Schneider JA, Bush WS, Haines JL, Mayeux R, Vardarajan BN, Albert MS, Thompson PM, Jefferson AL, Crane PK, Dumitrescu L, Archer DB, Hohman TJ, Gaynor LS. medRxiv. 2025 Jan 7; 2025 Jan 7. PMID: 39830268.
Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome.Yanez-Perez R, Garcia-Cabello E, Habich A, Cedres N, Diaz-Galvan P, Abdelnour C, Toledo JB, Barroso J, Ferreira D. Sci Rep. 2025 Jan 6; 2025 Jan 6. PMID: 39762366.
Peripheral Single-Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies.Qiu C, Zhang D, Wang M, Mei X, Chen W, Yu H, Yin W, Peng G, Hu S. CNS Neurosci Ther. 2025 Jan. PMID: 39754303.
Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy.Barisano G, Iv M, Choupan J, Hayden-Gephart M. EBioMedicine. 2025 Jan; 2024 Dec 24. PMID: 39721217.
Lewy body co-pathology in Alzheimer's disease and primary age-related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns.Almeida FC, Santos A, Jesus T, Coelho A, Quintas-Neves M, Gauthreaux K, Mock CN, Kukull WA, Crary JF, Oliveira TG. Alzheimers Dement. 2025 Jan; 2024 Dec 22. PMID: 39711133.
Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters KD, Shashikumar N, Pechman KR, Kim ME, Gao C, Mohd Khairi N, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford KA, Wilson JE, Cambronero FE, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Toga AW, Thompson PM, Mormino EC, Habes M, Wang D, Zhang P, Schilling K, Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB. Alzheimers Dement. 2025 Jan; 2024 Dec 22. PMID: 39711105.
Cerebral hypoperfusion reduces tau accumulation.Gheni G, Shinohara M, Masuda-Suzukake M, Shindo A, Watanabe A, Kawai K, Bu G, Tomimoto H, Hasegawa M, Sato N. Ann Clin Transl Neurol. 2025 Jan; 2024 Dec 2. PMID: 39621511.
Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification.Landau SM, Harrison TM, Baker SL, Boswell MS, Lee J, Taggett J, Ward TJ, Chadwick T, Murphy A, DeCarli C, Schwarz CG, Vemuri P, Jack CR Jr, Koeppe RA, Jagust WJ. Alzheimers Dement. 2025 Jan; 2024 Nov 19. PMID: 39559932.
Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.Liampas I, Siokas V, Stamati P, Zoupa E, Tsouris Z, Provatas A, Kefalopoulou Z, Chroni E, Lyketsos CG, Dardiotis E. J Am Geriatr Soc. 2025 Jan; 2024 Nov 5. PMID: 39499046.
Intra-individual variability in cognitive performance predicts functional decline in Parkinson's disease.Davis JJ, Sivaramakrishnan A, Rolin S, Subramanian S. Appl Neuropsychol Adult. 2025 Jan-Feb; 2023 Jan 10. PMID: 36628434.
Racial differences in positive findings on embedded performance validity tests.Hromas G, Rolin S, Davis JJ. Appl Neuropsychol Adult. 2025 Jan-Feb; 2022 Nov 23. PMID: 36416227.
Warfarin Versus Non-Vitamin K Inhibitor Medications and Cognitive Disease Progression in Atrial Fibrillation.Wood KA, Ko YA, Han F, Thunell J, Zissimopoulos J, Wharton W. J Cardiovasc Nurs. 2024 Dec 30; 2024 Dec 30. PMID: 39737787.
LD-informed deep learning for Alzheimer's gene loci detection using WGS data.Jo T, Bice P, Nho K, Saykin AJ. medRxiv. 2024 Dec 12; 2024 Dec 12. PMID: 39371140.
Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data.Chen C, Murphy TE, Speiser JL, Bandeen-Roche K, Allore H, Travison TG, Griswold M, Shardell M. J Gerontol A Biol Sci Med Sci. 2024 Dec 11. PMID: 39500720.
Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease.Safransky M, Groh JR, Blennow K, Zetterberg H, Tripodis Y, Martin B, Weller J, Asken BM, Rabinovici GD, Qiu WWQ, McKee AC, Stein TD, Mez J, Henson RL, Long J, Morris JC, Perrin RJ, Schindler SE, Alosco ML. Neurology. 2024 Dec 10; 2024 Nov 4. PMID: 39496102.
Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, Kuksa PP, Wang H, White H, Katanic Z, Bass L, Saravanan N, Greenfest-Allen E, Kirsch M, Cantwell L, Iqbal T, Wheeler NR, Farrell JJ, Zhu C, Turner SL, Gunasekaran TI, Mena PR, Jin J, Carter L, Zhang X, Vardarajan BN, Toga A, Cuccaro M, Hohman TJ, Bush WS, Naj AC, Martin E, Dalgard C, Kunkle BW, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. medRxiv. 2024 Dec 6; 2024 Dec 6. PMID: 39677464.
OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation.Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss CJ, Van Zandt M, Contessa JN. bioRxiv. 2024 Dec 5; 2024 Dec 5. PMID: 39677793.
X-chromosome-wide association study for Alzheimer's disease.Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L, Young J, Tripathi KP, Wang L, Varma A, Campos-Martin R, van der Lee S, Damotte V, de Rojas I, Palmal S, Lipton R, Reiman E, McKee A, De Jager P, Bush W, Small S, Levey A, Saykin A, Foroud T, Albert M, Hyman B, Petersen R, Younkin S, Sano M, Wisniewski T, Vassar R, Schneider J, Henderson V, Roberson E, DeCarli C, LaFerla F, Brewer J, Swerdlow R, Van Eldik L, Hamilton-Nelson K, Paulson H, Naj A, Lopez O, Chui H, Crane P, Grabowski T, Kukull W, Asthana S, Craft S, Strittmatter S, Cruchaga C, Leverenz J, Goate A, Kamboh MI, George-Hyslop PS, Valladares O, Kuzma A, Cantwell L, Riemenschneider M, Morris J, Slifer S, Dalmasso C, Castillo A, Küçükali F, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Pastor P, Sánchez-Valle R, Álvarez V, Boada M, García-González P, Puerta R, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Royo JL, Rodriguez-Rodriguez E, Soininen H, de Mendonça A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Thomassen JQ, Pijnenburg YAL, Holstege H, van Swieten J, Ramakers I, Verhey F, Scheltens P, Graff C, Papenberg G, Giedraitis V, Boland A, Deleuze JF, Nicolas G, Dufouil C, Pasquier F, Hanon O, Debette S, Grünblatt E, Popp J, Ghidoni R, Galimberti D, Arosio B, Mecocci P, Solfrizzi V, Parnetti L, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Spallazzi M, Seripa D, Rainero I, Daniele A, Bossù P, Masullo C, Rossi G, Jessen F, Fernandez V, Kehoe PG, Frikke-Schmidt R, Tsolaki M, Sánchez-Juan P, Sleegers K, Ingelsson M, Haines J, Farrer L, Mayeux R, Wang LS, Sims R, DeStefano A, Schellenberg GD, Seshadri S, Amouyel P, Williams J, van der Flier W, Ramirez A, Pericak-Vance M, Andreassen OA, Van Duijn C, Hiltunen M, Ruiz A, Dupuis J, Martin E, Lambert JC, Kunkle B, Bellenguez C. Mol Psychiatry. 2024 Dec 4; 2024 Dec 4. PMID: 39633006.
Early exposure to Western Diet exacerbates visual outcomes in female mice.Meseguer D, Furtado J, Zapadka T, Rodriguez A, Na D, Grajales-Reyes JG, Demb J, Eichmann A, Schneeberger M. bioRxiv. 2024 Dec 3; 2024 Dec 3. PMID: 39677769.
A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease.Qiu C, Xu H. Actas Esp Psiquiatr. 2024 Dec. PMID: 39665604.
Sex-specific topological structure associated with dementia via latent space estimation.Wang S, Wang Y, Xu FH, Tian X, Fredericks CA, Shen L, Zhao Y. Alzheimers Dement. 2024 Dec; 2024 Nov 12. PMID: 39530632.
Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.Andrews SJ, Boeriu AI, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K. Alzheimers Dement. 2024 Dec; 2024 Oct 21. PMID: 39428957.
Evaluating the updated LATE-NC staging criteria using data from NACC.Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA. Alzheimers Dement. 2024 Dec; 2024 Oct 1. PMID: 39352226.
Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2.Tumati S, Herrmann N, Perin J, Rosenberg PB, Lerner AJ, Mintzer J, Padala PR, Brawman-Mintzer O, van Dyck CH, Porsteinsson AP, Craft S, Levey A, Shade D, Lanctôt KL. Int Psychogeriatr. 2024 Dec; 2024 Sep 19. PMID: 39297292.
Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter SM, Lake EMR. J Neurotrauma. 2024 Dec; 2024 Sep 20. PMID: 39096127.
Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer's Disease.Li JS, Tun SM, Ficek-Tani B, Xu W, Wang S, Horien CL, Toyonaga T, Nuli SS, Zeiss CJ, Powers AR, Zhao Y, Mormino EC, Fredericks CA. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Dec; 2024 Jul 25. PMID: 39059466.
A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries-Differences by Chronic Disease and Race/Ethnicity.Quiñones AR, McAvay G, Vander Wyk B, Han L, Nagel C, Allore HG. J Aging Health. 2024 Dec; 2023 Oct 25. PMID: 37879084.
Distinct medical and substance use histories associate with cognitive decline in Alzheimer's Disease.Mansel C, Mazzotti DR, Townley R, Sardiu ME, Swerdlow RH, Honea RA, Veatch OJ. medRxiv. 2024 Nov 28; 2024 Nov 28. PMID: 39649607.
Cerebral amyloid angiopathy impacts neurofibrillary tangle burden and cognition.Godrich D, Pasteris J, Martin ER, Rundek T, Schellenberg G, Foroud T, Vance JM, Pericak-Vance MA, Cuccaro ML, Scott WK, Kukull W, Montine TJ, Beecham GW. Brain Commun. 2024; 2024 Nov 22. PMID: 39584156.
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.Huber HF, Ainsworth HC, Quillen EE, Salmon A, Ross C, Azhar AD, Bales K, Basso MA, Coleman K, Colman R, Darusman HS, Hopkins W, Hotchkiss CE, Jorgensen MJ, Kavanagh K, Li C, Mattison JA, Nathanielsz PW, Saputro S, Scorpio DG, Sosa PM, Vallender EJ, Wang Y, Zeiss CJ, Shively CA, Cox LA. bioRxiv. 2024 Nov 8; 2024 Nov 8. PMID: 39131309.
Prediction and clustering of Alzheimer's disease by race and sex: a multi-head deep-learning approach to analyze irregular and heterogeneous data.Chang CY, Slowiejko D, Win N. Sci Rep. 2024 Nov 4; 2024 Nov 4. PMID: 39496718.
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.Shade LMP, Katsumata Y, Abner EL, Aung KZ, Claas SA, Qiao Q, Heberle BA, Brandon JA, Page ML, Hohman TJ, Mukherjee S, Mayeux RP, Farrer LA, Schellenberg GD, Haines JL, Kukull WA, Nho K, Saykin AJ, Bennett DA, Schneider JA, Ebbert MTW, Nelson PT, Fardo DW. Nat Genet. 2024 Nov; 2024 Oct 8. PMID: 39379761.
Self-reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort.Miller AA, Sharp ES, Wang S, Zhao Y, Mecca AP, van Dyck CH, O'Dell RS. Alzheimers Dement. 2024 Nov; 2024 Sep 26. PMID: 39324520.
Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [(11)C]UCB-J PET.Young JJ, O'Dell RS, Naganawa M, Toyonaga T, Chen MK, Nabulsi NB, Huang Y, Cooper E, Miller A, Lam J, Bates K, Ruan A, Nelsen K, Salardini E, Carson RE, van Dyck CH, Mecca AP. J Nucl Med. 2024 Nov 1; 2024 Nov 1. PMID: 39299782.
The association between cigarette smoking and dementia with Lewy bodies.Goodheart AE, Gomperts SN. Parkinsonism Relat Disord. 2024 Nov; 2024 Sep 3. PMID: 39276722.
Neuropsychiatric symptoms and white matter hyperintensities in older adults without dementia.Liampas I, Siokas V, Zoupa E, Kyriakoulopoulou P, Stamati P, Provatas A, Tsouris Z, Tsimourtou V, Lyketsos CG, Dardiotis E. Int Psychogeriatr. 2024 Nov; 2024 Apr 19. PMID: 38639110.
Levetiracetam prevents Aβ(42) production through SV2a-dependent modulation of App processing in Alzheimer's disease models.Rao NR, DeGulis O, Nomura T, Lee S, Hark TJ, Dynes JC, Dexter EX, Dulewicz M, Ge J, Upadhyay A, Fornasiero EF, Vassar R, Hanrieder J, Contractor A, Savas JN. bioRxiv. 2024 Oct 28; 2024 Oct 28. PMID: 39554163.
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites.Tong T, Zhu C, Farrell JJ, Khurshid Z, Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Alzheimers Res Ther. 2024 Oct 23; 2024 Oct 23. PMID: 39444005.
Anatomic Interpretability in Neuroimage Deep Learning: Saliency Approaches for Typical Aging and Traumatic Brain Injury.Guo K, Chaudhari N, Jafar T, Chowdhury N, Bogdan P, Irimia A. Res Sq. 2024 Oct 16; 2024 Oct 16. PMID: 39483910.
Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.Liu Y, Tuttle MD, Kostylev MA, Roseman GP, Zilm KW, Strittmatter SM. J Am Chem Soc. 2024 Oct 9; 2024 Sep 26. PMID: 39326869.
Anatomic Interpretability in Neuroimage Deep Learning: Saliency Approaches for Typical Aging and Traumatic Brain Injury.Guo KH, Chaudhari NN, Jafar T, Chowdhury NF, Bogdan P, Irimia A. Neuroinformatics. 2024 Oct; 2024 Nov 6. PMID: 39503843.
Emergency Department Visits Among Patients With Dementia Before and After Diagnosis.Gettel CJ, Song Y, Rothenberg C, Kitchen C, Gilmore-Bykovskyi A, Fried TR, Brody AA, Nothelle S, Wolff JL, Venkatesh AK. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39401040.
Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Webber TA, Woods SP, Lorkiewicz SA, Yazbeck HW, Schultz ER, Kiselica AM. Neuropsychology. 2024 Oct; 2024 Aug 29. PMID: 39207439.
Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.Hou T, Liu K, Fa W, Liu C, Zhu M, Liang X, Ren Y, Xu S, Wang X, Tang S, Wang Y, Cong L, Tan Q, Du Y, Qiu C. Alzheimers Dement. 2024 Oct; 2024 Aug 22. PMID: 39171679.
CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease.Lizama BN, Williams C, North HA, Pandey K, Duong D, Di Caro V, Mecca AP, Blennow K, Zetterberg H, Levey AI, Grundman M, van Dyck CH, Caggiano AO, Seyfried NT, Hamby ME. Alzheimers Dement. 2024 Oct; 2024 Aug 21. PMID: 39166791.
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer's disease.Zhu X, Gao J, Qiu C. Metab Brain Dis. 2024 Oct; 2024 Aug 16. PMID: 39150655.
AI-based differential diagnosis of dementia etiologies on multimodal data.Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Poésy S, Kaliaev A, Andreu-Arasa VC, Dwyer BC, Farris CW, Hao H, Kedar S, Mian AZ, Murman DL, O'Shea SA, Paul AB, Rohatgi S, Saint-Hilaire MH, Sartor EA, Setty BN, Small JE, Swaminathan A, Taraschenko O, Yuan J, Zhou Y, Zhu S, Karjadi C, Alvin Ang TF, Bargal SA, Plummer BA, Poston KL, Ahangaran M, Au R, Kolachalama VB. Nat Med. 2024 Oct; 2024 Jul 4. PMID: 38965435.
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study.Salardini E, O'Dell RS, Tchorz E, Nabulsi NB, Huang Y, Carson RE, van Dyck CH, Mecca AP. bioRxiv. 2024 Sep 24; 2024 Sep 24. PMID: 39386453.
Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment.Zawar I, Kapur J, Mattos MK, Aldridge CM, Manning C, Quigg M. Neurology. 2024 Sep 24; 2024 Aug 22. PMID: 39173101.
Association of education attainment, smoking status, and alcohol use disorder with dementia risk in older adults: a longitudinal observational study.Tang H, Shaaban CE, DeKosky ST, Smith GE, Hu X, Jaffee M, Salloum RG, Bian J, Guo J. Alzheimers Res Ther. 2024 Sep 18; 2024 Sep 18. PMID: 39294787.
Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.Takahashi H, Perez-Canamas A, Lee CW, Ye H, Han X, Strittmatter SM. Commun Biol. 2024 Sep 5; 2024 Sep 5. PMID: 39237682.
Neuropsychiatric symptoms: Risk factor or disease marker? A study of structural imaging biomarkers of Alzheimer's disease and incident cognitive decline.Guan DX, Rehman T, Nathan S, Durrani R, Potvin O, Duchesne S, Pike GB, Smith EE, Ismail Z. Hum Brain Mapp. 2024 Sep. PMID: 39254167.
Use of alpha-adrenergic antagonists for lower urinary tract symptoms is not associated with worsening cognitive function.Berto FG, McClure JA, Campbell J, Welk B. Neurourol Urodyn. 2024 Sep; 2024 May 27. PMID: 38803218.
Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG-PET and structural MRI study.Cayir S, Volpi T, Toyonaga T, Gallezot JD, Yang Y, Sadabad FE, Mulnix T, Mecca AP, Fesharaki-Zadeh A, Matuskey D. J Neuroimaging. 2024 Sep-Oct; 2024 Apr 26. PMID: 38676301.
Montreal Cognitive Assessment's auditory items (MoCA-22): Normative data and reliable change indices.Amitrano NR, Lord AR, González DA. Appl Neuropsychol Adult. 2024 Aug 29; 2024 Aug 29. PMID: 39207946.
Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study.Li HM, Qiu CS, Du LY, Tang XL, Liao DQ, Xiong ZY, Lai SM, Huang HX, Kuang L, Zhang BY, Li ZH. Nutrients. 2024 Aug 28; 2024 Aug 28. PMID: 39275195.
The Montreal Cognitive Assessment: Norms and Reliable Change Indices for Standard and MoCA-22 Administrations.Ratcliffe LN, Hale AC, McDonald T, Hewitt KC, Nguyen CM, Spencer RJ, Loring DW. Arch Clin Neuropsychol. 2024 Aug 24. PMID: 38441951.
Development and Validity of Norms for Cognitive Dispersion on the Uniform Data Set 3.0 Neuropsychological Battery.Kiselica AM, Kaser AN, Weitzner DS, Mikula CM, Boone A, Woods SP, Wolf TJ, Webber TA. Arch Clin Neuropsychol. 2024 Aug 24. PMID: 38364295.
Dementia Risk Scores, APOE, and risk of Alzheimer disease: one size does not fit all.Andrews SJ, Boeriu AI, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K. medRxiv. 2024 Aug 16; 2024 Aug 16. PMID: 38746455.
Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults.Zhu Y, Williams J, Beyene K, Trani JF, Babulal GM. JAMA Netw Open. 2024 Aug 1; 2024 Aug 1. PMID: 39115844.
Neuropsychiatric symptom burden in early-onset and late-onset Alzheimer's disease as a function of age.Polsinelli AJ, Johnson S, Crouch A, Lane KA, Pena-Garcia A, Hammers DB, Wang S, Gao S, Apostolova LG. Alzheimers Dement. 2024 Aug; 2024 Jul 3. PMID: 38958543.
Neuropsychological and neuroanatomical underpinnings of the face pareidolia errors on the noise pareidolia test in patients with mild cognitive impairment and dementia due to Lewy bodies.Alsemari A, Boscarino JJ. J Clin Exp Neuropsychol. 2024 Aug; 2024 Jul 1. PMID: 38949538.
Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study.Lerfald M, Allore H, Nilsen TIL, Eldholm RS, Martinez-Velilla N, Selbæk G, Ernstsen L. J Gerontol A Biol Sci Med Sci. 2024 Aug 1. PMID: 38894618.
Commentary on "Study Partner Report of Apathy in Older Adults is Associated With AD Biomarkers: Findings From the Harvard Aging Brain Study".Khasnavis S, O'Dell RS, van Dyck CH, Mecca AP. Am J Geriatr Psychiatry. 2024 Aug; 2024 Apr 4. PMID: 38658231.
Chemical entity normalization for successful translational development of Alzheimer's disease and dementia therapeutics.Mullin S, McDougal R, Cheung KH, Kilicoglu H, Beck A, Zeiss CJ. J Biomed Semantics. 2024 Jul 31; 2024 Jul 31. PMID: 39080729.
Structural Brain Differences in the Alzheimer's Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium.Evans TE, Vilor-Tejedor N, Operto G, Falcon C, Hofman A, Ibáñez A, Seshadari S, Tan LCS, Weiner M, Alladi S, Anazodo U, Gispert JD, Adams HHH. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul 30; 2024 Jul 30. PMID: 39084525.