Clinical Core

The Clinical Core aims to perform research diagnostic evaluations for a large clinical population. Participating individualsare followed longitudinally with evaluation and deep characterization. Results from these evaluations are reviewed with participants and data is made available for research projects conducted by ADRC investigators and collaborators. The Core also makes data available to the National Alzheimer’s Coordinating Center (NACC) for national studies. The Core focuses on cell biology, integration of translational neuroscience, and systematic storage of biospecimens for current and future biomarker studies. Thus, the Core supplies biorepositories for whole blood (for DNA), plasma, cerebrospinal fluid (CSF), and peripheral blood mononuclear cells (PMCs) for the generation of induced pluripotent stem cells (iPSCs).

The Clinical Core is currently seeking participation from individuals with Alzheimer’s and other dementias, as well as Mild Cognitive Impairment (MCI). The Core is also enrolling cognitively healthy individuals with and without a family history of Alzheimer’s disease.

The staff of the Clinical Core meets weekly to review clinical cases and to discuss other Core issues.