The Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. It includes eight Cores (Administrative Core, Clinical Core, Data Management and Statistics Core, Biomarker Core, Neuropathology Core, Imaging Core, Outreach, Recruitment and Engagement Core, and Research Education Core), which will work together to achieve this goal.
The Data Management and Statistics Core (DMSC) provides data management and statistical support to meet operational and research needs. It interacts with other Yale ADRC Cores to manage and integrate metadata/data and provide statistical consultation on design and analysis of studies and educational and outreach program evaluation. The DMSC created and maintains data management and biorepository systems and procedures for subject tracking, accrual, and other conduct of study reports. The Data Management and Statistics Core ensures patient data confidentiality and...
ImagingCore
Human imaging studies allow for the development of imaging biomarkers of Alzheimer's disease and characterization of the temporal sequence of AD pathology, and lead to better assignment of patients to clinical research studies and clinical trials. Imaging is a major strength at Yale, as exemplified by the breadth and depth offered by the Yale PET Center and the Yale Magnetic Resonance Research Center (MRRC). In the PET Center, an example of recent, significant work is the introduction of PET synaptic imaging with the SV2A tracer 11C-UCB-J. In the MRI, the Yale MRRC has generated numerous...