Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeuronsEstrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function
Zsarnovszky A, Scalise T, Horvath T, Naftolin F. Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function. Brain Research 2000, 868: 363-366. PMID: 10854590, DOI: 10.1016/s0006-8993(00)02323-4.Peer-Reviewed Original ResearchConceptsSubstantia nigra compactaFemale ratsTyrosine hydroxylaseVentral mesencephalic dopaminergic neuronsTyrosine hydroxylase-immunoreactive cellsMesencephalic dopaminergic neuronsVentral tegmental areaTH-immunoreactive perikaryaDifferential effectsVentral mesencephalonTH immunoreactivityDopaminergic neuronsEstrogen effectsEstradiol benzoateTegmental areaMidbrain neuronsInterfascicular nucleusDopamine functionCell hypothesisRatsCell countingNeuronsPresent studyFurther evidenceOVX