2019
Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementEffects of guanfacinePlace preferenceFemale miceInfralimbic cortexArc immunoreactivityΑ2-adrenergic receptor agonistAnterior insulaNeurobiological mechanismsLateral central amygdalaNovel treatment optionsChamber preferencePlace preference acquisitionSex-dependent changesStress-induced relapseDose-response patternNucleus accumbens coreNicotine-dependent behaviorsSmoking occursTreatment optionsNicotine rewardReceptor agonistCentral amygdalaNeuronal activationPreclinical studies
2013
Galanin‐induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2
Einstein EB, Asaka Y, Yeckel MF, Higley MJ, Picciotto MR. Galanin‐induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. European Journal Of Neuroscience 2013, 37: 1541-1549. PMID: 23387435, PMCID: PMC3648588, DOI: 10.1111/ejn.12151.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsAbility of galaninSame receptor subtypeReceptor subtypesKnockout miceMorphine CPPPostsynaptic potentialsPlace preferenceAmplitude of EPSPsGalanin receptor 1Galanin receptor subtypesGalanin receptor 2Striatal brain slicesWild-type miceWhole-cell recordingsPotential cellular mechanismsNeuropeptide galaninEPSP amplitudeOpiate rewardBrain slicesNucleus accumbensDorsal striatumExcitatory signalingGalaninReceptor 2
2005
β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology 2005, 184: 328-338. PMID: 16133126, DOI: 10.1007/s00213-005-0099-z.Peer-Reviewed Original ResearchConceptsNicotine exposureNicotinic acetylcholine receptorsFood-reinforced respondingAcetylcholine receptorsPrior nicotine exposureNicotine-induced increasesProgressive ratioNicotinic receptor subtypesEffects of nicotineWild-type miceProgressive ratio testC57BL/6 miceReceptor subtypesConclusionThese dataChronic exposureReinforcement testingMiceΒ2 subunitUnpaired presentationsExposureReceptorsApproach trainingPresentationPaired presentationsPrimary reinforcementImpaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein. Journal Of Neuroscience 2005, 25: 2138-2145. PMID: 15728854, PMCID: PMC1352335, DOI: 10.1523/jneurosci.3530-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAvoidance LearningCalmodulin-Binding ProteinsConditioning, ClassicalCytoskeletonDendritesElectroshockFearFemaleFreezing Reaction, CatalepticGyrus CinguliHippocampusLearning DisabilitiesMaleMaze LearningMemory DisordersMiceMice, Inbred C57BLMice, KnockoutMice, Neurologic MutantsNerve Tissue ProteinsNeuronal PlasticityNucleus AccumbensRNA, MessengerConceptsBeta-adducinActin regulating proteinsCAMP-dependent mannerSynaptic plasticityActin cytoskeletonΒ-adducinCytoskeletal organizationPlasma membraneAdducinCellular mechanismsActivity-dependent synaptic plasticitySitu hybridizationPostsynaptic densityProteinPlasticitySpine morphologyImportant roleCytoskeletonSynaptic stimulationFamilyImpaired synaptic plasticityLong-term potentiationMiceMRNAHybridization
2004
Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
Wehner JM, Keller JJ, Keller AB, Picciotto MR, Paylor R, Booker TK, Beaudet A, Heinemann SF, Balogh SA. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 2004, 129: 11-24. PMID: 15489024, DOI: 10.1016/j.neuroscience.2004.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, ClassicalEthanolFearLearningMiceMice, KnockoutMutationNeuronsNicotineReceptors, NicotinicConceptsContextual learningForms of learningEffects of nicotineFear conditioningCued fear conditioningContextual fear conditioningCognitive enhancing effectsBeta2 null mutant miceNicotine effectsBeta4-containing receptorsShock stimuliEffects of ethanolBeta2-containing nAChRsLearningNull mutant miceTrainingConditioningBrain nicotinic acetylcholine receptorsMutant miceNicotineNeuronal nicotinic receptorsHomozygous null mutant miceWild-type littermatesMemoryNicotinic acetylcholine receptors
2002
Decreased Synaptic Vesicle Recycling Efficiency and Cognitive Deficits in Amphiphysin 1 Knockout Mice
Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O, De Camilli P. Decreased Synaptic Vesicle Recycling Efficiency and Cognitive Deficits in Amphiphysin 1 Knockout Mice. Neuron 2002, 33: 789-804. PMID: 11879655, DOI: 10.1016/s0896-6273(02)00601-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexClathrinConditioning, ClassicalEndocytosisFluorescent DyesGABA AntagonistsGlutamic AcidHumansMaze LearningMiceMice, KnockoutNerve Tissue ProteinsNeuronsPentylenetetrazoleProtein IsoformsPyridinium CompoundsQuaternary Ammonium CompoundsSurvival RateSynaptic Vesicles
2001
Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects
George T, Picciotto M, Verrico C, Roth R. Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects. Biological Psychiatry 2001, 49: 300-306. PMID: 11230881, DOI: 10.1016/s0006-3223(00)00928-8.Peer-Reviewed Original ResearchConceptsConditioned fear stressNicotine pretreatmentMedial prefrontal cortexFear stressDopamine metabolismNucleus accumbensPrefrontal cortexAcute footshock stressImmobility responseBehavioral responsesCortical dopaminergicDopamine utilizationCortical dopamineNicotine exposureFootshock stressNicotine dependenceAnxiolytic activityConditioned fear paradigmNicotine differsDay 21Psychological stressorsBehavioral effectsDopaminergicClinical contextPreferential activation