Featured Publications
Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients
Han L, Pisani MA, Araujo KL, Allore HG. Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. International Journal Of Statistics In Medical Research 2016, 5: 8-16. PMID: 27123153, PMCID: PMC4844076, DOI: 10.6000/1929-6029.2016.05.01.2.Peer-Reviewed Original ResearchDelirium severity scoresIntensive care unitSeverity scoreOld intensive care patientsIntensive care patientsOlder medical patientsDose of haloperidolStable patient characteristicsICU stayBaseline characteristicsAcute outcomesPatient characteristicsCare patientsCare unitMeasures of exposureMedical patientsAntipsychotic medicationFull cohortPatientsStable baselineAnalytic sampleTreatment effectsHaloperidolCohortScores
2023
Time to Diagnosis and Treatment of Non-small Cell Lung Cancer in Patients Undergoing Lung Cancer Screening
Bernstein E, DeRycke E, Han L, Bastian L, Bade B, Lerz K, Kravetz J, Carino M, Rose M, Akgun K, Cain H. Time to Diagnosis and Treatment of Non-small Cell Lung Cancer in Patients Undergoing Lung Cancer Screening. 2023, a2734-a2734. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2734.Peer-Reviewed Original ResearchAntibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Aggressive End-of-Life Care in the Veterans Health Administration versus Fee-for-Service Medicare among Patients with Advanced Lung Cancer
Presley CJ, Kaur K, Han L, Soulos PR, Zhu W, Corneau E, O'Leary JR, Chao H, Shamas T, Rose MG, Lorenz KA, Levy CR, Mor V, Gross CP. Aggressive End-of-Life Care in the Veterans Health Administration versus Fee-for-Service Medicare among Patients with Advanced Lung Cancer. Journal Of Palliative Medicine 2022, 25: 932-939. PMID: 35363053, PMCID: PMC9360181, DOI: 10.1089/jpm.2021.0436.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationEnd of lifeAggressive careLung cancerLife careMedicare beneficiariesAdvanced nonsmall cell lung cancerHealth AdministrationService MedicareNonsmall cell lung cancerLung cancer careAdvanced lung cancerCell lung cancerAggressive endHospice admissionCancer careConcurrent careCare availabilityCancer treatmentCareMedicareGreater declinePatientsCancerHospice
2020
Concurrent Hospice Care and Cancer-Directed Treatment for Advanced Lung Cancer and Receipt of Aggressive Care at the End of Life in the Veteran's Health Administration
Presley CJ, Han L, O'Leary JR, Zhu W, Corneau E, Chao H, Shamas T, Rose M, Lorenz K, Levy CR, Mor V, Gross CP. Concurrent Hospice Care and Cancer-Directed Treatment for Advanced Lung Cancer and Receipt of Aggressive Care at the End of Life in the Veteran's Health Administration. Journal Of Palliative Medicine 2020, 23: 1038-1044. PMID: 32119800, PMCID: PMC7404822, DOI: 10.1089/jpm.2019.0485.Peer-Reviewed Original ResearchConceptsNonsmall cell lung cancerVeterans Health AdministrationStage IV nonsmall cell lung cancerCancer-directed treatmentEnd of lifeAggressive careConcurrent careHealth AdministrationVHA facilitiesLung cancerHospice careConcurrent hospice careLung cancer careAdvanced lung cancerCell lung cancerMultilevel logistic regression modelsLogistic regression modelsPrimary outcomeCancer careHospice useStudy periodCareLast monthPatientsVeterans
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2013
Cardiovascular Disease and Hip Fracture among Older Inpatients in Beijing, China
Xu B, Han L, Liu H, Wang J, Bao XY, Xi HX, Zhao L, Yu GP. Cardiovascular Disease and Hip Fracture among Older Inpatients in Beijing, China. BioMed Research International 2013, 2013: 493696. PMID: 23936809, PMCID: PMC3713359, DOI: 10.1155/2013/493696.Peer-Reviewed Original ResearchConceptsHip fractureICD-10 codesCardiovascular diseaseHypertensive diseaseOlder inpatientsCerebrovascular diseaseHospitalization summary reportsOverall cardiovascular diseaseHip fracture patientsDiagnosis of CVDOccurrence rateChinese inpatientsFracture patientsCohort studyTertiary hospitalInpatientsDiseaseAssociationFracturesEuropean populationsComorbiditiesPatientsHospitalYearsDiagnosis
2010
P3‐066: Antidepressant use and cognitive function in older primary care patients with major or minor depression: A prospective cohort study with database linkage
Han L, McCusker J, Cole M, Capek R, Abrahamowicz M. P3‐066: Antidepressant use and cognitive function in older primary care patients with major or minor depression: A prospective cohort study with database linkage. Alzheimer's & Dementia 2010, 6: s468-s468. DOI: 10.1016/j.jalz.2010.05.1560.Peer-Reviewed Original Research
2006
Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia
Sharma G, Han L, Quagliarello V. Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia. Infectious Diseases In Clinical Practice 2006, 14: 365-368. DOI: 10.1097/01.idc.0000227715.26754.e7.Peer-Reviewed Original ResearchCommunity-acquired pneumoniaMonths postdischargeFunctional outcomeLong-term functional outcomeElderly patientsADL declineMean ADLMean ageInclusion criteriaFunctional declineDaily livingPostdischargeElderly adultsPatientsOlder adultsCollected databaseMonthsHospitalizationPneumoniaPotential subjectsAdultsOutcomesIllnessADLDeclineTriggered sampling could help improve longitudinal studies of persons with elevated mortality risk
Dubin JA, Han L, Fried TR. Triggered sampling could help improve longitudinal studies of persons with elevated mortality risk. Journal Of Clinical Epidemiology 2006, 60: 288-293. PMID: 17292023, DOI: 10.1016/j.jclinepi.2006.06.012.Peer-Reviewed Original ResearchConceptsElevated mortality riskMortality riskChronic obstructive pulmonary diseaseLongitudinal studyCongestive heart failureObstructive pulmonary diseaseMixed effects modelsLongitudinal observational studyLongitudinal clinical studyStudy design featuresEffects modelHeart failurePulmonary diseaseAdvanced illnessTreatment preferencesClinical studiesObservational studyFirst triggerStudy designPatientsRiskValuable additionMean preferenceSimilar resultsIllnessRecoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness
Inouye SK, Zhang Y, Han L, Leo‐Summers L, Jones R, Marcantonio E. Recoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness. Journal Of General Internal Medicine 2006, 21: 1276-1281. PMID: 16965558, PMCID: PMC1924736, DOI: 10.1111/j.1525-1497.2006.00613.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAgedAged, 80 and overCognition DisordersCohort StudiesDeliriumDementiaEducational StatusFemaleHospitalizationHumansIncidenceMalePredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecovery of FunctionSeverity of Illness IndexConceptsMini-Mental State ExaminationCognitive dysfunctionAcute illnessOlder personsProspective cohort studyAdjusted odds ratioHigher illness severityPotential clinical implicationsMajority of casesHigher educational levelCohort studyHospital admissionPrimary outcomeIllness severityMultivariable analysisConsecutive admissionsOdds ratioAcademic hospitalFunctional impairmentMMSE scoresState ExaminationDeliriumMMSE impairmentDysfunctionPatients
2005
189-S: The Temporal Relationship Between Depression and Cognitive Functioning in Older Medical Patients — Prospective or Cross-Sectional?
Han L, McCusker J, Abrahamowicz M, Cole M, Capek R. 189-S: The Temporal Relationship Between Depression and Cognitive Functioning in Older Medical Patients — Prospective or Cross-Sectional? American Journal Of Epidemiology 2005, 161: s48-s48. DOI: 10.1093/aje/161.supplement_1.s48.Peer-Reviewed Original Research
2003
The Prognostic Significance of Subsyndromal Delirium in Elderly Medical Inpatients
Cole M, McCusker J, Dendukuri N, Han L. The Prognostic Significance of Subsyndromal Delirium in Elderly Medical Inpatients. Journal Of The American Geriatrics Society 2003, 51: 754-760. PMID: 12757560, DOI: 10.1046/j.1365-2389.2003.51255.x.Peer-Reviewed Original ResearchConceptsElderly medical inpatientsMedical inpatientsPrognostic significanceLonger acute care hospital staysAcute care hospital stayCore symptomsAcute care hospitalsPostdischarge mortalityRevised (DSM-III-R) criteriaHospital stayCohort studyCare hospitalRisk factorsSubsyndromal deliriumDementia statusImportant syndromeDeliriumPhysiological severityMore symptomsAdmissionMental disordersSymptomsPatientsFirst weekInpatients
2002
Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia
Cole MG, McCusker J, Dendukuri N, Han L. Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia. Journal Of Neuropsychiatry 2002, 14: 167-175. PMID: 11983791, DOI: 10.1176/jnp.14.2.167.Peer-Reviewed Original Research
2000
Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis
Han L, Cole M, Bellavance F, McCusker J, Primeau F. Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis. International Psychogeriatrics 2000, 12: 231-247. PMID: 10937543, DOI: 10.1017/s1041610200006359.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationAD patientsAlzheimer's diseaseCognitive declineInclusion criteriaStudy populationMMSE scoresState ExaminationCourse of ADPathological diagnostic criteriaEffect sizeInitial MMSE scoreNumber of assessmentsLongitudinal study designOutcome measuresDiagnostic criteriaPopulation characteristicsFollowing keywordsMeta-AnalysisPatientsStudy designDiseaseChange scoresRandom effects regression modelsSignificant heterogeneity