2024
Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data
Chen C, Murphy T, Speiser J, Bandeen-Roche K, Allore H, Travison T, Griswold M, Shardell M. Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data. The Journals Of Gerontology Series A 2024, glae269. PMID: 39500720, DOI: 10.1093/gerona/glae269.Peer-Reviewed Original ResearchData scienceAdaptation of machine learningEra of Big DataSoftware resourcesBig DataComputer scienceMachine learningCutting-edge methodsIntegration of informationTechnological landscapeAnalysis of high-dimensional omics dataOpen scienceDataHigh-dimensional omics dataIntersection of statisticsGerontological researchSub-disciplineInformationThe extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesRandomized Clinical Trials That Advance Health and Health Equity
Wang T, Corbie G, Allore H, Anderson T, Durant R, Ganguli I, Grady D, Gross C, Katz M, Mody L, Tripodis Y, Inouye S. Randomized Clinical Trials That Advance Health and Health Equity. JAMA Internal Medicine 2024, 184: 1011-1012. PMID: 39008289, DOI: 10.1001/jamainternmed.2024.3149.Peer-Reviewed Original ResearchResiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer
Presley C, Grogan M, Compston A, Hock K, Knauss B, Redder E, Arrato N, Lo S, Janse S, Benedict J, Hoyd R, Williams N, Hayes S, Wells-Di Gregorio S, Gill T, Allore H, Focht B, Quist M, Carbone D, Spakowicz D, Paskett E, Andersen B. Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer. Journal Of Geriatric Oncology 2024, 15: 101844. PMID: 39174449, DOI: 10.1016/j.jgo.2024.101844.Peer-Reviewed Original ResearchShort Physical Performance BatterySupportive care interventionsProgressive muscle relaxationPhysical therapyCare interventionsOlder adultsVirtual healthSelf-report measures of functional statusTwo-minute walk testPatient Health Questionnaire-9Functional statusMeasures of functional statusAdvanced lung cancerGeneralized Anxiety Disorder-7Physical Performance BatteryActivity monitor dataEQ-5D-5LEvaluated in-personParticipants' functional statusCancer treatmentHealth sessionsPerformance BatteryResistance bandsPost-interventionWalk testEarly-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder AdultsUS adultsMultimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
Liu R, Nagel C, Chen S, Newsom J, Allore H, Quiñones A. Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis. BMC Geriatrics 2024, 24: 571. PMID: 38956501, PMCID: PMC11221032, DOI: 10.1186/s12877-024-05158-z.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyMultimorbidity patternsCare needsOlder adultsSelf-careInformal careLatent class analysisCare receiver characteristicsCombinations of multimorbidityPerson-centered carePatterns of multimorbidityDifferential care needsUS older adultsAssociated with lower oddsAssociated with higher oddsGroup of older adultsMultinomial logistic regression modelModerate cognitive impairmentClass analysisLogistic regression modelsInformal caregiversBackgroundOlder adultsCare recipientsMultimorbidity groupsChronic conditionsValue in Optimizing the Components of App Interventions Before Final Testing
Allore H, Katz M. Value in Optimizing the Components of App Interventions Before Final Testing. JAMA Internal Medicine 2024, 184: 760-760. PMID: 38805201, DOI: 10.1001/jamainternmed.2024.0833.Peer-Reviewed Original ResearchLongitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study
Lerfald M, Allore H, Nilsen T, Eldholm R, Martinez-Velilla N, Selbæk G, Ernstsen L. Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study. The Journals Of Gerontology Series A 2024, 79: glae161. PMID: 38894618, PMCID: PMC11266981, DOI: 10.1093/gerona/glae161.Peer-Reviewed Original ResearchEstimated cardiorespiratory fitnessCardiorespiratory fitnessDementia riskHUNT StudyRisk differenceAssociated with reduced dementia riskPopulation-based HUNT StudyAssociated with dementia riskOdds ratioPoor cardiorespiratory fitnessHigher cardiorespiratory fitnessRisk of dementiaEstimate odds ratiosRisk factorsModifiable risk factorsAge groupsAPOE e4 statusProspective cohort studyBlood pressureMultivariate logistic regressionHigh blood pressureMiddle-aged groupLongitudinal patternsE4 statusSystolic blood pressureFunctional disability and receipt of informal care among Chinese adults living alone with cognitive impairment
Liu X, Li C, Jin S, Cao X, Hoogendijk E, Han L, Xu X, Allore H, Feng Q, Zhang Q, Liu Z. Functional disability and receipt of informal care among Chinese adults living alone with cognitive impairment. Experimental Gerontology 2024, 194: 112490. PMID: 38876449, DOI: 10.1016/j.exger.2024.112490.Peer-Reviewed Original ResearchActivities of daily livingBurden of functional disabilityInformal careFunctional disabilityActivities of daily living disabilityCognitive impairmentChinese adultsInstrumental Activities of Daily Living (IADLReceipt of informal careNormal cognitionLong-term care servicesIADL disabilityInstrumental activitiesMobility disabilityProvision of long-term care servicesChina HealthFunctional healthCare servicesDaily livingMatched comparatorsOdds ratioMonthly hoursVulnerable subpopulationsCareDisabilityMental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults
Chen S, Nagel C, Liu R, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults. PLOS ONE 2024, 19: e0303599. PMID: 38743678, PMCID: PMC11093294, DOI: 10.1371/journal.pone.0303599.Peer-Reviewed Original ResearchConceptsOdds of cognitive impairmentGroup-based trajectory modelingMultimorbidity combinationsLate-life increaseOlder adultsNon-Hispanic white adultsHigh riskHealth and Retirement StudyMiddle-agedHealth-related factorsTrajectories of cognitive functionCognitive declineCognitive impairmentMultinomial logistic regression modelMultinomial logistic regression analysisLow riskLogistic regression modelsLow initial riskTrajectory group membershipLogistic regression analysisRetirement StudyNon-HispanicMultimorbidityWhite adultsHispanic respondentsRecommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose
Nagel C, Bishop N, Botoseneanu A, Allore H, Newsom J, Dorr D, Quiñones A. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose. The Journals Of Gerontology Series A 2024, 79: glae122. PMID: 38742711, PMCID: PMC11163923, DOI: 10.1093/gerona/glae122.Peer-Reviewed Original ResearchConceptsStudy of multimorbidityHealth-related quality of lifeMeasures of multimorbidityEffect of multimorbidityPerson-centered outcomesHealth-related outcomesHealth-related qualityLongitudinal studyQuality of lifeHealth-related dataMultimorbidity researchHealth domainsMultimorbidityLate-lifePeriod of changeAging populationOperationalizing changeLongitudinal analysisLongitudinal changesMore advanced stagesQuantitative studyOutcomesResearch objectHealthPractical issuesImproving Women’s Health Across the Life Span—JAMA Internal Medicine Call for Papers
Grady D, Allore H, Corbie G, Covinsky K, Durant R, Ganguli I, Gross C, Katz M, Mody L, Wang T, Tripodis Y, Inouye S. Improving Women’s Health Across the Life Span—JAMA Internal Medicine Call for Papers. JAMA Internal Medicine 2024, 184: 472-473. PMID: 38497973, PMCID: PMC11184509, DOI: 10.1001/jamainternmed.2024.0136.Peer-Reviewed Original ResearchFeedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial
Vislapuu M, Patrascu M, Allore H, Husebo B, Kjerstad E, Gedde M, Berge L. Feedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial. Innovation In Aging 2024, 8: igae020. PMID: 38550899, PMCID: PMC10976912, DOI: 10.1093/geroni/igae020.Peer-Reviewed Original ResearchInformal care timeCare timeInformal caregiversCaregiving experienceMulticomponent interventionStepped-wedge randomized controlled trialMild to moderate dementiaDementia Care CoordinationHome-dwelling personsInformal caregivers' experiencesInformal caregiver supportComplex intervention studiesDementia careRandomized controlled trialsCare coordinationCaregiving situationCaregiver supportSymptom managementGlobal Impression of ChangeClinical Global Impression of ChangeCare situationsModerate dementiaHealth servicesCare burdenImpression of ChangeMultimorbidity Patterns, Hospital Uses and Mortality by Race and Ethnicity Among Oldest-Old Patients
Cho J, Allore H, Rahimighazikalayeh G, Vaughn I. Multimorbidity Patterns, Hospital Uses and Mortality by Race and Ethnicity Among Oldest-Old Patients. Journal Of Racial And Ethnic Health Disparities 2024, 1-10. PMID: 38381325, DOI: 10.1007/s40615-024-01929-x.Peer-Reviewed Original ResearchOldest-old patientsClinic visitsAssociated with EDHealthcare systemEmergency departmentPatterns of multimorbidityHealthcare service utilizationIntegrated healthcare systemGeneralized estimating equationsRacial-ethnic groupsMultimorbidity patternsMultimorbidity clustersMinoritized patientsEmergency careService utilizationProportional hazards survival modelChronic conditionsOldest-oldHospital useDiverse patientsMultimorbidityAge-related risk factorsHospital servicesRace-ethnicityRacial-ethnic variationsProfile of Caregiving Activities and Association With Physical Health Among Dementia Spousal Caregivers
Cho J, Sands L, Stevens A, Allore H, Horstman M. Profile of Caregiving Activities and Association With Physical Health Among Dementia Spousal Caregivers. Innovation In Aging 2024, 8: igae017. PMID: 38524243, PMCID: PMC10960627, DOI: 10.1093/geroni/igae017.Peer-Reviewed Original ResearchSpousal caregivers of personsCaregivers of personsSpousal caregiversPhysical activityHealth indicatorsHealth-promoting behaviorsElectronic health recordsPhysical health indicatorsSelf-reported fatigueSleep disturbanceLow-intensity groupFrequency of healthCaregiving intensityCare recipientsCaregiving experiencePain interferenceCaregiving activitiesPhysical functionHealth behaviorsPromoting behaviorsHealth recordsChronic conditionsPhysical healthCaregiversEffective interventionsPrior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Di Pietro C, Haberman A, Lindenbach B, Smith P, Bruscia E, Allore H, Vander Wyk B, Tyagi A, Zeiss C. Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Viruses 2024, 16: 246. PMID: 38400021, PMCID: PMC10891789, DOI: 10.3390/v16020246.Peer-Reviewed Original ResearchConceptsTransient gene expressionSARS-CoV-2Viral replication pathwayReplication pathwayAntiviral pathwaysEndemism patternsUpregulation of innateGene expressionQuantitative RT-PCRMitigated weight lossDual-infected animalsSARS-CoV-2 viral loadSARS-CoV-2 infectionSyrian hamstersSeasonal infection ratesSARS-CoV-2 inoculationLungs of animalsIndividual virusesSARS-CoV-2 diseaseUpper respiratory tractH1N1 infectionRT-PCRBronchoalveolar lavageViral loadCytokine levelsLongitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients
Liu R, Vander Wyk B, Quiñones A, Allore H. Longitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients. Research On Aging 2024, 46: 327-338. PMID: 38261524, PMCID: PMC11472584, DOI: 10.1177/01640275241229162.Peer-Reviewed Original ResearchSkilled-nursing facilityCare recipientsNational Health and Aging Trends StudyGeneralized estimating equation modelsCenters for MedicareLikelihood of hospitalizationMedicaid Services dataCaregiver networkUnpaid caregiversHealthcare utilizationTrends StudyAssociated healthcare utilizationOlder adultsCaregiversRisk ratioSurvey wavesService dataCareHospitalAssociationAdmissionMedicareMedicaidAdultsEquation modelingDischarge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention
Pettersen T, Schjøtt J, Allore H, Bendz B, Borregaard B, Fridlund B, Hadjistavropoulos H, Larsen A, Nordrehaug J, Rasmussen T, Rotevatn S, Valaker I, Wentzel-Larsen T, Norekvål T, Investigators C. Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention. Heart Lung And Circulation 2024, 33: 350-361. PMID: 38238118, DOI: 10.1016/j.hlc.2023.12.005.Peer-Reviewed Original ResearchSelf-reported adverse drug reactionsPrescribed pharmacotherapyPotential adverse drug reactionsAdverse drug reactionsPercutaneous coronary interventionPatient-reported outcome measuresCovariate-adjusted logistic regressionConfidence intervalsNational quality registryProspective multicentre cohort studyAssociated with incidencePatients' medical recordsIntervention aimHealthcare providersQuality registryMulticentre cohort studyDischarge informationDrug reactionsInformation patientsOdds ratioOutcome measuresCohort studyHospital dischargeLogistic regressionPCI centre‘When age is not a barrier’: an explorative study of nonagenarian patients’ experiences of undergoing percutaneous coronary intervention
Instenes I, Fridlund B, Borregaard B, Larsen A, Allore H, Bendz B, Deaton C, Rotevatn S, Fålun N, Norekvål T. ‘When age is not a barrier’: an explorative study of nonagenarian patients’ experiences of undergoing percutaneous coronary intervention. European Journal Of Cardiovascular Nursing 2024, 23: 608-617. PMID: 38243638, DOI: 10.1093/eurjcn/zvad132.Peer-Reviewed Original ResearchPatient experiencePercutaneous coronary interventionHealthy food choicesPercutaneous coronary intervention proceduresIn-hospital pathwaysQualitative content analysisCardiac rehabilitationIn-depth interviewsMental healthSub-themesCardiac wardRehabilitation strategiesTreatment trajectoryFood choicesTertiary university hospitalPost-procedure experiencesLifelong responsibilityHealthy lifeCoronary interventionShort stayContent analysisUniversity HospitalNonagenariansIn-hospital stayHospital
2023
DEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY
Monin J, McAvay G, Zang E, Vander Wyck B, Carrión C, Allore H. DEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY. Innovation In Aging 2023, 7: 94-95. PMCID: PMC10735856, DOI: 10.1093/geroni/igad104.0307.Peer-Reviewed Original ResearchAlzheimer's Disease Research CenterCase-control studyNational Alzheimer's Coordinating CenterDisease Research CenterNPI symptomsDivorce/separationCoordinating CenterAgitation/aggressionDepression/dysphoriaAdjusted odds ratioDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitNeuropsychiatric symptomsOdds ratioNPI scoresMarried casesStandardized clinical informationClinical informationGreater oddsBehavioral symptomsControl studyControl status