2024
Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study
Lerfald M, Allore H, Nilsen T, Eldholm R, Martinez-Velilla N, Selbæk G, Ernstsen L. Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study. The Journals Of Gerontology Series A 2024, 79: glae161. PMID: 38894618, PMCID: PMC11266981, DOI: 10.1093/gerona/glae161.Peer-Reviewed Original ResearchEstimated cardiorespiratory fitnessCardiorespiratory fitnessDementia riskHUNT StudyRisk differenceAssociated with reduced dementia riskPopulation-based HUNT StudyAssociated with dementia riskOdds ratioPoor cardiorespiratory fitnessHigher cardiorespiratory fitnessRisk of dementiaEstimate odds ratiosRisk factorsModifiable risk factorsAge groupsAPOE e4 statusProspective cohort studyBlood pressureMultivariate logistic regressionHigh blood pressureMiddle-aged groupLongitudinal patternsE4 statusSystolic blood pressure
2023
RACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS
Chen S, Nagel C, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. RACIAL/ETHNIC AND MULTIMORBIDITY DIFFERENCES IN DEMENTIA ONSET AMONG MIDDLE-AGED AND OLDER ADULTS. Innovation In Aging 2023, 7: 747-747. PMCID: PMC10737488, DOI: 10.1093/geroni/igad104.2416.Peer-Reviewed Original ResearchDementia onsetRace/ethnicityHigh riskOlder adultsModifiable risk factorsNon-Hispanic blacksCovariate-adjusted modelsContext of multimorbidityNon-Hispanic white respondentsNon-Hispanic White older adultsWhite older adultsRacial/EthnicMultimorbidity combinationsRisk factorsDiscrete-time survival modelsHigh prevalenceHigher oddsMultimorbidityWhite adultsDementiaMiddle AgedLater lifeAdultsSignificant differencesRisk
2018
A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity
Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song Y, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee P, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l400-l405. PMID: 30520689, PMCID: PMC6397351, DOI: 10.1152/ajplung.00439.2018.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorChronic obstructive pulmonary diseaseMIF -794 CATTAbnormal diffusion capacityCigarette smoke exposureSmoke exposureAssociation of MIFDiffusion capacityMacrophage migration inhibitory factor (MIF) promoter polymorphismsPathogenesis of COPDChronic cigarette smoke exposureMultivariable logistic regression modelModifiable risk factorsObstructive pulmonary diseaseMigration inhibitory factorCross-sectional analysisLogistic regression modelsCommon genetic polymorphismsInnate immune genesAirflow obstructionMIF expressionCOPD severityPulmonary diseaseMIF allelesRisk factors
2013
Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2005
Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes
Allore HG, Tinettia M, Gill TM, Peduzzi PN. Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes. Clinical Trials 2005, 2: 13-21. PMID: 16279575, DOI: 10.1191/1740774505cn067oa.Peer-Reviewed Original ResearchConceptsMultifactorial health conditionsModifiable risk factorsMulticomponent interventionRisk factorsGeriatric syndromesHealth conditionsMultifactorial geriatric syndromeOutcomes of interestIntervention trialsClinical trialsClinical concernIntervention componentsInterventionSyndromeDeleterious effectsTrialsOutcomesBlindingFactors