2023
Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study
Cao X, Li X, Zhang J, Sun X, Yang G, Zhao Y, Li S, Hoogendijk E, Wang X, Zhu Y, Allore H, Gill T, Liu Z. Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study. JMIR Public Health And Surveillance 2023, 9: e45502. PMID: 37200070, PMCID: PMC10236284, DOI: 10.2196/45502.Peer-Reviewed Original ResearchConceptsMultiple adverse outcomesChronic kidney diseaseDiabetes-related microvascular diseaseAdverse outcomesCause mortalityCardiovascular diseaseMiddle-aged adultsUK Biobank participantsHigh riskMicrovascular diseaseEye diseaseIncident type 2 diabetes mellitusType 2 diabetes mellitusProportional hazards regression modelsBiobank participantsMultivariable-adjusted modelsProspective cohort studyHazards regression modelsNormal glucose metabolismDiabetes-related burdenDiabetes-related diseasesHealth care resourcesNonfrail counterpartsFrailty assessmentCohort study
2020
An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer’s Disease and Related Dementia
Quiñones AR, Kaye J, Allore HG, Botoseneanu A, Thielke SM. An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer’s Disease and Related Dementia. American Journal Of Alzheimer's Disease & Other Dementias® 2020, 35: 1533317520960874. PMID: 32969234, PMCID: PMC7984095, DOI: 10.1177/1533317520960874.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseEthnic disparitiesMultiple chronic diseasesMultimorbidity combinationsPoor outcomeAdverse outcomesChronic diseasesHigh burdenRelated dementiaClinical treatmentDiseaseADRDU.S. populationDementia researchMultimorbidityOutcomesBurdenRiskBroad effectsPopulationDementiaDisparitiesCareCaregivers
2012
A method for partitioning the attributable fraction of multiple time-dependent coexisting risk factors for an adverse health outcome.
Lin H, Allore HG, McAvay G, Tinetti ME, Gill TM, Gross CP, Murphy TE. A method for partitioning the attributable fraction of multiple time-dependent coexisting risk factors for an adverse health outcome. American Journal Of Public Health 2012, 103: 177-82. PMID: 22515873, PMCID: PMC3518339, DOI: 10.2105/ajph.2011.300458.Peer-Reviewed Original ResearchConceptsHealth outcomesAttributable fraction methodPrecipitating Events ProjectAdverse health outcomesMultiple diseasesAcute episodeNew onsetHeart failureAdverse outcomesRisk factorsAttributable fractionNew Haven CountyDiseaseIndividual diseasesOlder adultsOutcomesAdditive effectDeathEvent outcomesOnsetPneumoniaCohort
2002
Understanding the Treatment Preferences of Seriously Ill Patients
Fried TR, Bradley EH, Towle VR, Allore H. Understanding the Treatment Preferences of Seriously Ill Patients. New England Journal Of Medicine 2002, 346: 1061-1066. PMID: 11932474, DOI: 10.1056/nejmsa012528.Peer-Reviewed Original ResearchConceptsBurden of treatmentTreatment preferencesAdverse outcomesCognitive impairmentChronic obstructive pulmonary diseaseLow-burden treatmentCongestive heart failureObstructive pulmonary diseaseSevere functional impairmentLimited life expectancyOutcome of treatmentAdvance care planningYears of agePercent of participantsLife-sustaining treatmentHeart failureIll patientsPulmonary diseaseQuestions patientsPatient preferencesPrimary diagnosisPatients' attitudesFunctional impairmentHigh burdenCare planning