2008
Lack of TIM-3 Immunoregulation in Multiple Sclerosis
Yang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 Immunoregulation in Multiple Sclerosis. The Journal Of Immunology 2008, 180: 4409-4414. PMID: 18354161, DOI: 10.4049/jimmunol.180.7.4409.Peer-Reviewed Original ResearchConceptsMultiple sclerosisT cell functionTim-3Untreated patientsTreatment of MSType 1 Th cellsBlocking Tim-3Tim-3 functionTim-3 regulationT-cell infiltratesTim-3 expressionPeripheral immune systemCell functionHuman autoimmune diseasesIFN-gamma secretionCNS white matterT cell stimulationHuman Tim-3Cell infiltrateGlatiramer acetateImmune toleranceAutoimmune diseasesControl subjectsTh cellsInflammatory diseases
2000
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population
Anderson D, Bieganowska K, Bar-Or A, Oliveira E, Carreno B, Collins M, Hafler D. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine 2000, 6: 211-214. PMID: 10655112, DOI: 10.1038/72323.Peer-Reviewed Original ResearchConceptsCTLA-4 blockadeT cell populationsCTLA-4T cellsMonoclonal antibodiesB7-1B7-2Immune responseCytotoxic T-lymphocyte antigen-4Whole T cell populationsT-lymphocyte antigen-4Antigen-specific T cellsT cell activation stateHuman T cell populationsT cell functionT cell receptor signalsCo-stimulatory signalsDifferent T cellsT cell stimulationEffect of B7T cell activationActivation stateT cell receptorHuman T cellsFab fragments
1996
Induction of anergy in CD8 T cells by B cell presentation of antigen.
Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of anergy in CD8 T cells by B cell presentation of antigen. The Journal Of Immunology 1996, 157: 5269-76. PMID: 8955172, DOI: 10.4049/jimmunol.157.12.5269.Peer-Reviewed Original ResearchMeSH KeywordsAntigen-Presenting CellsB7-1 AntigenB-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCell LineClonal AnergyCytotoxicity, ImmunologicGene ExpressionHumansImmunologic MemoryInterleukin-2Lymphocyte ActivationMembrane GlycoproteinsReceptors, Antigen, T-CellSignal TransductionTranscription, GeneticConceptsCD8 T cellsT cell clonesInduction of anergyT cellsB cellsMononuclear cellsB7-1Cell clonesAg stimulationAnergic CD8 T cellsPeptide-pulsed B cellsPeptide-pulsed target cellsCD4 T-cell clonesCD8 T cell clonesSecondary Ag challengeExogenous IL-2B7-2 costimulationB cell presentationT cell anergyIL-2 secretionNormal proliferative responseIL-2 mRNA transcriptionT cell stimulationEarly tyrosine phosphorylationAdequate costimulation
1995
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.
Höllsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4036-4040. PMID: 7732026, PMCID: PMC42097, DOI: 10.1073/pnas.92.9.4036.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBinding SitesB-LymphocytesCD8-Positive T-LymphocytesCell DivisionCell Line, TransformedCytotoxicity, ImmunologicGene Products, taxHerpesvirus 4, HumanHLA-A2 AntigenHuman T-lymphotropic virus 1HumansKineticsLymphocyte ActivationMolecular Sequence DataMutagenesis, Site-DirectedPoint MutationThymidineConceptsCD8 T cellsInterleukin-2 secretionT cell receptor contact residuesT cellsReceptor contact residuesCD8 T cell clonesCytotoxic CD8 T cellsMyelopathy/tropical spastic paraparesisT cell-mediated cytotoxicityHAM/TSPTropical spastic paraparesisT cell clonesAltered peptide ligandT cell-mediated cytolysisHuman T-cell leukemia virus type IT cell stimulationVirus type IAnalog peptidesHLA-A2Spastic paraparesisNeurologic diseaseSecondary stimulationSecondary responsePeptide antigensPrimary activation
1994
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.
Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. Journal Of Experimental Medicine 1994, 179: 279-290. PMID: 7505801, PMCID: PMC2191316, DOI: 10.1084/jem.179.1.279.Peer-Reviewed Original ResearchConceptsT cell clonesMyelin basic proteinMultiple sclerosisCell clonesT cellsImmunodominant myelin basic protein peptideMBP-reactive T cellsMajor histocompatibility complex class IIDR2 haplotypeHistocompatibility complex class IIImmunodominant T cell epitopesHuman T cell clonesAutoreactive T cellsReactive T cellsT cell epitopesMyelin basic protein peptideT cell stimulationT cell receptorMS patientsDRB1 moleculesDR2 antigenRestriction elementsCell epitopesTarget antigenClass II