1997
Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease
Bieganowska K, Ausubel L, Modabber Y, Slovik E, Messersmith W, Hafler D. Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease. Journal Of Experimental Medicine 1997, 185: 1585-1594. PMID: 9151896, PMCID: PMC2196290, DOI: 10.1084/jem.185.9.1585.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsT cellsMultiple sclerosisPersistent T cellsT cell frequenciesHuman autoimmune diseasesSubpopulation of patientsT cell clonesT cell receptorSingle T cellsMyelin basic proteinAutoimmune diseasesAutoantigenic peptidesAntigen stimulationDirect exCell frequencyTCR transcriptsFlow cytometryCell receptorCell clonesBeta chainHigh frequencyCell deathBasic proteinChain transcripts
1993
T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen.
LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R, Hafler DA. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. The Journal Of Immunology 1993, 151: 649-57. PMID: 7687620, DOI: 10.4049/jimmunol.151.2.649.Peer-Reviewed Original ResearchConceptsStaphylococcal enterotoxin BT cell clonesT cellsT cell presentationAnergy inductionCalcium fluxMHC classCell contactHuman T cell clonesCell interactionsT cell coculturesT cell responsesMHC class IIT cell interactionsT cell migrationIndividual T cellsSingle T cellsSubsequent anergyHLA-DRIndividual CD4Class IIAnergyEnterotoxin BSuperantigensSelf-Stimulation