1998
Isolation and Characterization of PNUTS, a Putative Protein Phosphatase 1 Nuclear Targeting Subunit*
Allen P, Kwon Y, Nairn A, Greengard P. Isolation and Characterization of PNUTS, a Putative Protein Phosphatase 1 Nuclear Targeting Subunit*. Journal Of Biological Chemistry 1998, 273: 4089-4095. PMID: 9461602, DOI: 10.1074/jbc.273.7.4089.Peer-Reviewed Original ResearchConceptsPhosphatase 1 nuclear targeting subunitProtein phosphatase 1Targeting subunitPP1 catalytic activityMammalian cell lysatesTwo-hybrid assayPP1 functionsNuclear functionsNuclear compartmentalizationNovel proteinPhosphatase 1Subcellular localizationCell physiologyCell lysatesCell nucleiSubunitsExogenous substratesInitial characterizationProteinStable complexesPotent modulationChromatinCloningMitosisCompartmentalization
1992
The role of protein phosphatases in synaptic transmission, plasticity and neuronal development
Nairn A, Shenolikar S. The role of protein phosphatases in synaptic transmission, plasticity and neuronal development. Current Opinion In Neurobiology 1992, 2: 296-301. PMID: 1322750, DOI: 10.1016/0959-4388(92)90118-5.Peer-Reviewed Original ResearchConceptsNeuronal developmentSerine/threonineRole of proteinsProtein phosphataseProtein dephosphorylationMolecular cloningTyrosine proteinIon channelsNervous systemPast year significant advancesNeuronal functionNeurotransmitter receptorsSpecific neuronsProteinSelective inhibitorEnzymeYears significant advancesSynaptic transmissionDephosphorylationCloningThreonineRolePhosphataseRegulationPlasticity