2006
The effects of sex and hormonal status on restraint-stress-induced working memory impairment
Shansky RM, Rubinow K, Brennan A, Arnsten A. The effects of sex and hormonal status on restraint-stress-induced working memory impairment. Behavioral And Brain Functions 2006, 2: 8. PMID: 16522198, PMCID: PMC1420310, DOI: 10.1186/1744-9081-2-8.Peer-Reviewed Original ResearchRestraint stressStress-related disordersPrefrontal cortexFemale ratsHormonal statusCognitive functionPFC cognitive functionAcute restraint stressHigh estrogen levelsMajor depressive disorderMinutes of restraintMethodsThe present studyDendritic remodelingEstrogen levelsDepressive disorderMale ratsPharmacological stressorHormonal influencesMemory impairmentHippocampal functionSignificant impairmentNeuronal morphologyConclusionThese resultsEstrus phaseOestrous cycle
2000
The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys
Arnsten A, Murphy B, Merchant K. The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys. Neuropsychopharmacology 2000, 23: 405-410. PMID: 10989267, DOI: 10.1016/s0893-133x(00)00133-0.Peer-Reviewed Original ResearchConceptsD4 receptor antagonistReceptor mechanismsReceptor antagonistDopamine D1 receptor mechanismsStress-induced cognitive dysfunctionPrefrontal cortexSelective dopamine D4 receptor antagonistSelective D4 receptor antagonistD1 receptor mechanismsDose-related reversalDopamine D4 receptor antagonistCognitive dysfunctionPharmacological stressorHigh dosesLow dosesMemory deficitsCognitive deficitsStress exposureFurther studiesCognitive functioningAntagonistFG7142DosesPreliminary findingsMonkeys
1999
A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex
Birnbaum S, Gobeske K, Auerbach J, Taylor J, Arnsten A. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex. Biological Psychiatry 1999, 46: 1266-1274. PMID: 10560032, DOI: 10.1016/s0006-3223(99)00138-9.Peer-Reviewed Original ResearchConceptsStress-induced cognitive deficitsPoor attention regulationAlternation performanceSpatial working memoryPFC cognitive functionPrefrontal cortical dysfunctionMotor response timeIntra-PFC infusionsStress-induced deficitsStress-induced impairmentWorking memoryAttention regulationPFC contributeMemory performanceAlternation testingStress researchNeuropsychiatric disordersPrefrontal cortexCognitive deficitsCognitive functionMemory functionMemory impairmentPFC dysfunctionPerseverative patternsPharmacological stressor
1997
Clozapine Reverses the Spatial Working Memory Deficits Induced by FG7142 in Monkeys
Murphy B, Roth R, Arnsten A. Clozapine Reverses the Spatial Working Memory Deficits Induced by FG7142 in Monkeys. Neuropsychopharmacology 1997, 16: 433-437. PMID: 9165499, DOI: 10.1016/s0893-133x(97)00019-5.Peer-Reviewed Original ResearchConceptsMemory deficitsClozapine dosesCognitive deficitsDA receptor stimulationLow clozapine dosesDose-related impairmentPFC cognitive deficitsSpatial Working Memory DeficitsClozapine pretreatmentClozapine reversesAtypical neurolepticsPharmacological stressorDopamine dysregulationReceptor stimulationCognitive functionNonhuman primatesClinical rangeDosesWorking Memory DeficitsClozapineMonkeysDeficitsFG7142SchizophreniaCurrent study