Jaime Grutzendler MD

Associate Professor of Neurology and of Neurobiology; Director, Center for Experimental Neuroimaging

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Medicine, Pharmacology, and Physiology

Office of Student ResearchInterdepartmental Neuroscience ProgramCancer Center, Yale: Signal TransductionVascular Biology and Therapeutics ProgramNeurobiologyNeurology: Alzheimer's Disease/Dementia and Neuro-degenerative Disorders; Grutzendler Lab

Research Interests

Neuro-glio-vascular interactions, cerebral blood flow and metabolism blood-brain barrier, two-photon microscopy, myelin imaging, synaptic plasticity, development and pathology of the brain microvasculature, Neuroinflammationin, neurodegenerative diseases and stroke more...


  • M.D., Universidad Javeriana School of Medicine, 1991

Selected Publications

  • Microglia constitute a barrier that prevents neurotoxic protofibrillar Aß42 hotspots around plaques. Condello C, Yuan P, Schain A, Grutzendler J. Nature Comms. 2015 Jan 29;6 :6176.
  • In vivo imaging of oligodendrocytes using sulforhodamine 101. R. Hill and J. Grutzendler. Nature Methods, 2014. Oct 30;11:1081-1082.
  • Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Schain A, Hill R, Grutzendler J. Nature Medicine. 2014 Mar 30; Epub 2014 Mar 30.



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