Jaime Grutzendler, MD

Associate Professor of Neurology and of Neurobiology; Director, Center for Experimental Neuroimaging

Research Interests

Neurosciences

Research Organizations

Cancer Center, Yale: Signal Transduction

Interdepartmental Neuroscience Program

Neurology: Grutzendler Lab

Vascular Biology and Therapeutics Program

Research Summary

The dynamics and logic of neuro-glio-vascular interactions in health and disease

The overall goal of our laboratory is to uncover rules that govern the complex interactions between all brain cell types in their unperturbed in vivo environment and to determine how these dynamic cell-cell interactions are disrupted in a variety of disease states.We combine high-resolution cellular imaging in vivo and fixed tissues of single cells and small clusters of interacting cells with novel optical sensors of cellular physiology, optogenetics, chemogenetics, genome editing techniques delivered by viral vectors or in utero electroporation. Our studies are initially exploratory and hypothesis generating but as we observe unique and interesting features we develop novel experimental approaches to test such hypotheses. Because of this approach, our results take us in different directions such that projects in the lab can have a neuronal, glial or vascular focus and can be geared towards understanding normal physiology or neuropathology (such as Alzheimer's disease, microvascular and demyelinating disorders).

Extensive Research Description

  • IN VIVO IMAGING:The majority of projects in the laboratory are imaging-oriented. We use a variety of techniques including transcranial in vivo two photon microscopy, high-resolution confocal, spectral confocal reflectance microscopy (SCoRe) and electron microscopy in combination with differential fluorescent cell labeling and genetic/pharmacological manipulations. We aim at developeing novel imaging strategies and methods to better understand the pathophysiology of a variety of neurological disorders.
  • MICROVASCULAR PLASTICITY: microvascular recanalization and angioplasticity after cerebral embolic occlusion. We have recently described a new mechanism of microvascular plasticity which leads to vessel recanalization (Angiophagy). We are investigating the molecular control and physiological relevance of this novel mechanism.
  • "NEURO-GLIO-VASCULAR UNIT" FUNCTION AND PATHOLOGY: Understanding the postnatal development and pathology of neuro-glio-vascualr interactions, neurovascular coupling, tissue oxygenation. Astrocyte physiology.
  • AXON AND SYNAPSE DEGENERATION/REGENERATION: Wa have recently developed a method for imaging myelinated axons in vivo (Spectral confocal reflectance microscopy SCoRe), which we are currently using to explore questions related to myelin's role in degeneration and regeneration.
  • ALZHEIMER"S DISEAESE: understanding the dynamics of neurodegenerative conditions such as Alzheimer's disease. We study the interactions between microglia, neurons and amyloid plaques to understand the sequence of events leading to neural dysfunction in AD.

Selected Publications

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Contact Info

Jaime Grutzendler, MD
Patient Care Location
Yale Memory ClinicYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
Lab Location
300 George Street, Ste 8300G
New Haven, CT 06511
Office Location
300 George Street, Ste 353G
New Haven, CT 06511
Mailing Address
PO Box 208018
New Haven, CT 06520-8018

Grutzendler Lab