Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders
Psychiatry: Center for the Translational Neuroscience of Alcoholism | Human Genetics, Division of | Molecular Psychiatry, Division of | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | VA Alcohol Research Center | VA-Yale Clinical Neurosciences PTSD Research Program
The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including cocaine, opioid, nicotine, and alcohol dependence, PTSD, panic and other anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.
The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include NIH-funded multicenter case/control association studies with the goal of identifying genes predisposing to cocaine, opioid, nicotine, and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; an international drug dependence genetics training project in collaboration with Chulalongkorn Faculty of Medicine (Bangkok, Thailand); and studies of posttraumatic stress disorder (PTSD).
Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Gene mapping
- Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA. (2014) Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
- Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, and Gelernter J (2014) Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
- Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans. Biol Psychiatry. 2012 Apr 18. [Epub ahead of print]
- Li D, Zhao H, Gelernter J: Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases. Biol Psychiatry. 2011 6:504-12. PMID: 21497796 PMCID: PMC3142297 NIHMS:282602
- Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, and Gelernter J (2011) Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
- Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, and Gelernter J: The Interactive Effect of Stressful Life Events and Serotonin Transporter 5-HTTLPR Genotype on PTSD Diagnosis In Two Independent Populations. Arch Gen Psychiatry. 2009 Nov; 66(11):1201-9 PMID: 19884608 NIHMSID188327
- Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Wang Q, Yang C, Gelernter J, Zhao H. Hum Genet. Sep 4.
- Dissecting ancestry genomic background in substance dependence genome-wide association studies. Polimanti R, Yang C, Zhao H, Gelernter J. Pharmacogenomics. 2015 Aug;16(13):1487-98. doi: 10.2217/pgs.15.91. Epub 2015 Aug 12.
- Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Biol Psychiatry. 2015 Mar 1;77(5):493-503. doi: 10.1016/j.biopsych.2014.08.025. Epub 2014 Sep 16