Animal Diseases; Neuroanatomy; Neurobiology; Ophthalmology; Pathologic Processes; Primates; Neurodegenerative Diseases; Informatics; Translational Medical Research
Why do so many promising animal studies fail to translate to successful treatments for humans? Our lab uses biomedical informatics to identify large scale patterns of animal model. This approach reveals systemic biases in the utilization of animal models that contribute to the translational gap. In particular, we are interested in methods that can correlate interventional outcomes across human and animal species by intervention, drug class and choice of outcome measure. We focus on chronic and complex diseases, in particular neurodegenerative disease. This focus is informed by extensive animal models experience using small and large animal models of retinal and neurodegenerative disease.
Specialized Terms: Biomedical informatics; Efficacy; Translational gap; Neurodegeneration; Neurobiology of movement disorders; Phenotypes of genetically engineered mice; Evolutionary biology of the eye; Veterinary Pathology; Mouse Phenotyping; Ocular pathology; Neuroanatomy of age-related gait disorders;
From Reproducibility to Translation in Neurodegenerative Disease.
Zeiss CJ. ILAR J. Apr 21:1-9.
Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease.
Zeiss CJ, Allore HG, Beck AP. PLoS One. 2017 Feb 9;12(2):e0171790.
β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares
Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. Cell Rep. 2017 Feb 28;18(9):2077-2087
Improving the predictive value of interventional animal models data.
Zeiss CJ. Drug Discov Today. 2015 Apr;20(4):475-82.
Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor β Pathway.
Sati L, Zeiss C, Yekkala K, Demir R, McGrath J. Mol Cell Biol. 2015 Oct;35(19):3436-45.
Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits.
Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA. Hum Gene Ther Clin Dev. 2014 Dec;25(4):202-11.
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.
Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11876-81.
Mutation of POLB causes lupus in mice.
Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB. Cell Rep. 2014 Jan 16;6(1):1-8.
Translational models of ocular disease.
Zeiss CJ. Vet Ophthalmol. 2013 Jul;16 Suppl 1:15-33
Fungal polymerase chain reaction testing in equine ulcerative keratitis.
Zeiss C, Neaderland M, Yang FC, Terwilliger G, Compton S. Vet Ophthalmol. 2013 Sep;16(5):341-51
Designing phenotyping studies for genetically engineered mice.
Zeiss CJ, Ward JM, Allore HG. Vet Pathol. 2012 Jan;49(1):24-31
Animals as models of age-related macular degeneration: an imperfect measure of the truth.
Zeiss CJ. Vet Pathol. 2010 May;47(3):396-413.
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR 3rd, Perrin S, Feany MB, Horwich AL. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1392-7.
Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer.
Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J. Mol Ther. 2008 Mar;16(3):458-65.