Joel Gelernter, MD

Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience; Director, Division of Human Genetics (Psychiatry)

Research Interests

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

Research Organizations

Psychiatry: Center for the Translational Neuroscience of Alcoholism | Human Genetics, Division of | Molecular Psychiatry, Division of | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | VA Alcohol Research Center | VA-Yale Clinical Neurosciences PTSD Research Program

Global Health Initiative

Office of Cooperative Research

Research Summary

The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including cocaine, opioid, nicotine, and alcohol dependence, PTSD, panic and other anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.

The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to cocaine, opioid, nicotine, and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; an international drug dependence genetics training project in collaboration with Chulalongkorn Faculty of Medicine (Bangkok, Thailand); studies of posttraumatic stress disorder (PTSD); and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Pschiatric Genomics Consortium.

Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics

Selected Publications

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