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Angeliki Louvi, PhD

Professor of Neurosurgery and of Neuroscience
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Additional Titles

Deputy Director, MD-PhD Program

About

Titles

Professor of Neurosurgery and of Neuroscience

Deputy Director, MD-PhD Program

Biography

Dr. Angeliki Louvi (PhD, Columbia University Irving Medical Center, 1997) is Professor of Neurosurgery and of Neuroscience, Deputy Director of the MD-PhD Program, and member of the Yale Interdepartmental Neuroscience Program (INP) and the Yale Program on Neurogenetics. She is interested in understanding how the perturbation of basic biological processes leads to clinically significant brain pathology. Her laboratory investigates the cellular and molecular mechanisms underlying cerebrovascular and structural brain disorders associated with specific genetic lesions.

Appointments

Education & Training

Postdoctoral Fellow
University of Chicago (2004)
Postdoctoral Fellow
École normale supérieure (2001)
PhD
Columbia University Irving Medical Center, Genetics and Development (1997)
BS
University of Athens (1987)

Research

Overview

Cerebral Cavernous Malformations (CCM)

  1. Louvi, A.*, Chen, L., Two, A. M., Zhang, H., Min, W., and Günel, M.* (2011). Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc. Natl. Acad. Sci. USA. 108, 3737-3742. PMID: 21321212.
  2. Louvi, A.*, Nishimura, S. and Gunel, M. (2014). Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development, 141, 1404-1415. PMID: 24595293.
  3. Nishimura, S., Mishra-Gorur, K., Park, J., Surovtseva, Y., Sebti, S.M., Levchenko, A., Louvi, A.* and Gunel, M.* (2017). Combined HMG-CoA reductase and prenylation inhibition in treatment of CCM. Proceedings of the National Academy of Sciences USA. 114(21):5503-5508. doi: 10.1073/pnas.1702942114. PMID: 28500274.
  4. Peyre, M., Miyagishima, D., Bielle, F., Chapon, F., Sierant, M., Venot, Q., Lerond, J., Marijon, P., Abi-Jaoude, S., Le Van, T., Labreche, K., Houlston, R., Faisant, M., Clemenceau, S., Boch, A.-L., Nouet, A., Carpentier, A., Boetto, J., Louvi, A., Kalamarides, M. (2021) Recurrent Somatic PIK3CA mutations in Sporadic Cerebral Cavernous Malformations. New England Journal of Medicine 2021 Sep 9;385(11):996. doi: 10.1056/NEJMoa2100440. PMID: 34496175.
  5. Louvi, A., Nishimura, S., and Gunel, M. (2022). Genetics of Cerebral Cavernous Malformations. In Youmans and Winn’s Neurological Surgery, 8th edition, H. Richard Winn, Editor-in-Chief. Chapter 460, p.3760-3768.e6. Elsevier (Philadelphia, PA).


Structural Brain Disorders

  1. Bilgüvar, K.*, Oztürk, A. K.*, Louvi, A., Kwan, K. Y., Choi, M., Tatli, B., Yalnizoglu, D., Tüysüz, B., Caglayan, A. O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioglu, M., Yasuno, K., Ho, W., Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M. H., Bronen, R. A., Koçer, N., Per, H., Mane, S., Pamir, M. N., Yalçinkaya, C., Kumandas, S., Topçu, M., Ozmen, M., Sestan, N., Lifton, R. P., State, M. W., and Günel, M. (2010). Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 467, 207-210. PMID: 20729831.
  2. Sgourdou, P., Mishra-Gorur, K., Saotome, I., Henagariu, O., Tuysuz, B., Campos, C., Ishigame, K., Giannikou, K., Quon, J.L., Sestan, N., Caglayan, A.O., Gunel, M., and Louvi, A*. (2017) Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Scientific Reports 7:43708. doi: 10.1038/srep43708. PMID: 28272472.
  3. Dell’Amico, C., Angulo Salavarria, M.M., Takeo, Y., Saotome, I., Dell’Anno, M.T., Galimberti, M., Pellegrino, E., Cattaneo, E., Louvi, A.*, Onorati, M.* (2023) Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors. eLife Jun 5;12:e81716. doi: 10.7554/eLife.81716. PMID37272619.

Current Projects

  • Cellular and Molecular Mechanisms of Structural Brain Disorders
  • Biology and Pathobiology of Cerebral Cavernous Malformations
  • Intracranial Aneurysms

Medical Subject Headings (MeSH)

Brain; Disease Models, Animal; Hemangioma, Cavernous, Central Nervous System; Induced Pluripotent Stem Cells; Intracranial Aneurysm; Lissencephaly; Microcephaly; Morphogenesis; Nervous System Diseases; Organoids

Research at a Glance

Yale Co-Authors

Frequent collaborators of Angeliki Louvi's published research.

Publications

2024

2023

2019

2018

Teaching & Mentoring

Teaching

  • Didactic

    INP 701: Principles of Neuroscience

    Course DirectorLecture Setting

Get In Touch

Contacts

Academic Office Number
Lab Number
Office Fax Number
Mailing Address

Neurosurgery

PO Box 208082

New Haven, CT 06520-8082

United States