The December 2023 issue of the Yale Journal of Biology and Medicine (YJBM), on Cell Fate, has been published on PubMed Central. This focus issue features articles on cellular decisions in development, wound healing, and immune systems—and how cells determine their own fate.
Highlights of the issue include an original research paper by Abass et al. (Kafrelsheikh University, Kafrelsheikh, Egypt) where they have identified new possible roles of OMA1 and YME1L in the staging of hepatocellular carcinoma driven signaling molecules in mice.
A brief communication by McDonald et al. (Salk Institute for Biological Studies, La Jolla, CA) explore the role of temporality in immunological cell fate by looking at the differential chromatin remodeling CD8+ T cells undergo depending on the duration of antigen stimulation.
A case report by John et al. (Texas A&M University School of Medicine, Bryan, TX) illustrates an event of melanoma mimicking a primary tumor in the breast of a patient and describes the immunochemistry workup that lead to the correct diagnosis.
Last, we present a perspectives piece by Ramsey and Durand (KU Leuven, Leuven, Belgium; and University of the Witwatersrand, Johannesburg, South Africa) which examines the theoretical frameworks of cell fate and evolution in programmed cell death.
Read the entire YJBM archive for free on PubMed Central. The YJBM is open-access for all.
Deputy Editors of this issue: Josef Alavi (MD/PhD Program, Yale School of Medicine) and Morgan Vanderwall (Department of Molecular, Cellular, and Developmental Biology, Yale University)