DEFIANCE: Randomized Clinical Trial of ClotTriever system versus anticoagulation in Deep Vein Thrombosis

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.

Currently enrolling patients with:

• Iliofemoral and unilateral DVT
• Symptom onset within 12 weeks of enrollment in the study

Follow-up schedule:

• Patients follow-up tp 6 months

Mechanical thrombectomy with the ClotTriever

Single session procedure

• No thrombolytics or ICU stay required