Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
Diseases of the Nervous System
What is the purpose of this trial?
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective.
- Ages14 years and older
- Trial withUniversity of Michigan
- Start Date07/24/2020
- End Date07/01/2023
- Last Updated08/04/2021
- Study HIC#2000024956