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Diseases of the Nervous System

Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)

What is the purpose of this trial?

BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective.

  • Trial with
    National Institute of Neurological Disorders and Stroke (NINDS) and University of Michigan
  • Ages
    14 years and older
  • Gender
    Both

Contact Information

For more information about this study, including how to volunteer, contact Michael Kampp

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

  • Last Updated
    07/03/2024
  • Study HIC
    #2000024956