For Researchers & Research Professionals

The Yale Center for Clinical Investigation (YCCI) provides the expertise, infrastructure, and resources that enable Yale investigators to conduct high-quality, innovative clinical and translational research. From early project development to study close-out, YCCI supports researchers in advancing science, improving health, and securing future funding.

By centralizing key research functions and offering coordinated guidance, YCCI helps faculty, staff, and trainees focus on what matters most—transforming ideas into discoveries that make a difference.

YCCI provides infrastructure, expertise and resources to enable investigators to conduct high-quality clinical and translational research. Our multidisciplinary teams are designed to streamline study start-up, ensure regulatory compliance and support investigators, staff, and trainees at every stage—from initial concept through study close-out. By centralizing key functions and offering coordinated guidance, we help investigators focus on advancing science and improving health outcomes. Services include:

• Protocol activation and study management – Coordinated support for study planning, activation, and ongoing operations.
• Regulatory and compliance guidance – Expertise in meeting federal, state, and institutional requirements, including clinical research billing compliance.
• Resource coordination – Access to specialized facilities, tools, and institutional resources that strengthen study design and execution.
• Letters of support and documentation – Assistance with CTSA letters and other materials to facilitate grant submissions and sponsor engagement.

Through these services, YCCI accelerates the pace of research, reduces administrative barriers, and promotes the highest standards of quality and integrity. Our collaborative approach ensures that each study benefits from Yale’s full research enterprise—linking investigators with the expertise and infrastructure needed to bring innovative ideas to life.

YCCI’s Pilot Awards Program provides competitive funding to Yale faculty for new and innovative projects that have strong scientific merit and potential for future extramural support. The program helps investigators collect essential preliminary data, strengthen future grant proposals, and accelerate the translation of promising ideas into funded research.

Through this program, YCCI invests in discovery-driven science that aligns with its mission to advance clinical and translational research across Yale and beyond.

YCCI supports the professional growth of Yale’s research workforce through comprehensive, hands-on training for clinical and translational research professionals. Open to Yale faculty, staff, and Yale New Haven Health System personnel, these programs build core competencies in research ethics, regulatory compliance, data systems, and good clinical practice—ensuring that every study conducted at Yale meets the highest standards of quality and integrity. Explore upcoming courses and certification opportunities designed to help you advance your research career.

View information about all stages of a study, from proposals, statistics, development, registration, activation, recruitment, safety monitoring, project management, monitoring, data management, analysis, audits, and study conduct to protocol closure, publication, and dissemination.