YCCI as a CTSA hub
The Yale Center for Clinical Investigation (YCCI) was founded in 2005 with the goal to advance clinical and translational research at Yale University. Shortly thereafter, YCCI became home to Yale’s Clinical and Translational Science Award (CTSA), with Yale being one of the first 12 institutions to receive the CTSA from the National Center for Advancing Translational Science (NCATS). In combination with support from the CTSA, YCCI has enabled Yale to push the boundaries of clinical and translational research and science, fostering innovation that has helped scientists overcome research barriers, accelerated the identification, evaluation, and dissemination of novel diagnostics and treatments, and nurtured collaborations within our local community and with other research institutions nationally. YCCI supports investigators with guidance, collaboration and services through each stage of clinical research, including study development, activation, conduct, closure, and dissemination.
Through Yale’s CTSA Grants (5UL1TR001863; 5KL2TR001862; 5TLTR001864) and support from Yale School of Medicine, YCCI offers several intramural career development opportunities including the YCCI scholar Awards (KL2), Pre and Post Doctoral Training Programs (T awards). Pilot awards are also offered to catalyze early-stage research projects related to translational science. These programs enable researchers to pursue innovative projects, develop their skills and new research methods, and contribute to the advancement of knowledge in their fields.
Along with these funding opportunities and training programs, the Yale CTSA has a series of long-standing partnerships with members of the community designed to enhance the generalizability and impact of our clinical research on health outcomes for all members of society. Our CTSA has also invested in bioinformatics and data science, along with dissemination and implementation science, all to promote the advancement of translational science in the Yale University community and nationally through partnerships with a number of institutions, including other CTSA hubs.
Foci of YCCI & the Yale CTSA
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Scholars & Trainees
Junior Faculty Scholars:
The YCCI Junior Faculty Scholars Program began in 2006 as the educational arm of the Yale Center for Clinical Investigation. The mission remains to attract a diverse group of highly talented junior faculty across multiple disciplines in the Schools of Medicine, Nursing, Public Health and Biomedical Engineering who are interested in pursuing careers in any aspect (T1-T4) of translational research: to imbue them with a spirit of discovery; to train them in the use of state-of-the-art research tools; to give them the skills to work in complex and diverse multidisciplinary research teams; and to support their professional development. Members of the Yale community can find more information on the YCCI Junior Faculty Scholars Program.
Multidisciplinary Post-Doctoral Training Program:
Funded by the Yale CTSA, this program focuses on providing post-doctoral trainees the opportunity to develop and participate in multidisciplinary team research with the mentorship of Yale faculty in two or more disciplines. This training program seeks to support outstanding trainees who specifically want to pursue careers in clinical and translational research; to train them in the use of state-of-the-art research tools; to enhance their abilities to work collaboratively in complex multidisciplinary research teams; and to provide outstanding mentoring (including concordant mentoring) by experienced faculty that support the trainee’s long-term professional development. Members of the Yale community can find more information on the YCCI Multidisciplinary Post-Doctoral Training Program.
Multidisciplinary Pre-Doctoral Training Program:
The Multidisciplinary Pre-Doctoral Training Program in Translational Research aims to identify and support a representative and broad group of outstanding trainees who specifically want to pursue careers in clinical and translational research; to train them in the use of state-of-the-art research tools; to enhance their abilities to work collaboratively in complex multidisciplinary research teams; to provide outstanding mentoring (including concordant mentoring) by experienced faculty that support the trainee’s long-term professional development. Members of the Yale community can find more information on the YCCI Multidisciplinary Pre-Doctoral Training Program.
Pilot Programs
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The YCCI Pilot Program is aimed at providing funding to interdisciplinary teams focused on solving clinical translational science problems through innovation, efficiency, and community engagement. Projects funded through this program typically focus on one or more of the following areas:
- Interdisciplinary team-based research projects focused on solving clinical translational science problems through innovation, efficiency, and community-engagement.
- Increasing participation in clinical trials and observational studies for all populations in our health system.
- Accelerating the development and incorporation of new research methods, technology, and data science solutions
Members of the Yale community can find more information on YCCI’s Pilot Program, active opportunities and instructions on how to apply.
Community Engagement
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Yale has engaged stakeholders across the translational spectrum, both within and outside the University, to advance the translation of new discoveries across the research continuum. These efforts have drawn upon the entire Yale Hub: our clinical practice and physicians, including patients; community organizations, and faith-based and advocacy groups; educational institutions in the US and abroad; and industry and regulatory partners.
The YCCI community engagement program seeks to improve the health outcomes for all members of society by ensuring that communities and Yale researchers have the capacity and opportunity to participate as full partners, which includes joint establishment of Hub research priorities; co-design principles for research protocols, active recruitment and retention practices to engage under-studied patient populations in clinical research, effective implementation and dissemination strategies; and increased public support for research.
Informatics
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YCCI and the Yale CTSA have substantially expanded informatics infrastructure and the development of novel methods involving informatics and bioinformatics. Yale and it’s health system partner, Yale New Haven Health System (YNHHS), continue to make significant investments in IT infrastructure for security, privacy-protecting data science, and computational capacity. The informatics team is dedicated to studying health services and biomedical research processes and outcomes, developing new strategies and tools, implementing and evaluating innovative services and innovations to iteratively improve health outcomes. The ultimate goal of these research activities is not only to improve our regional infrastructure but also importantly to disseminate learnings across the national CTSA network of hubs and to work with our partners from other CTSA hubs. Services include database creation and management, clinical trial management, and integration of research applications with the Epic Electronic Health Record (EHR) system (mostly through Fast Healthcare Interoperability Resources – FHIR standards), research data ethics and regulatory support. Real-world data (RWD) from EHRs from YNHHS and Epic Cosmos and from claims data, Picture Archiving and Communication System (PACS) for research, and a state-of-the-art secure compute AI-enabled environment for HIPAA protected data are provided to the Yale community.
Dissemination and Implementation
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Yale has unique depth in Dissemination & Implementation (D&I) science with each of the health professional schools having centers or program dedicated to this area. YCCI is engaged and dedicated to support this area, as seen through trainings offered, pilot awards funded, and methodological support provided in D&I. Under the leadership of Dr. Nicola Hawley, YCCI provides office hours where faculty, trainees, and community partners can be linked with Yale-based D&I expertise. The D&I team has expertise in novel trial designs to allow patients with limited clinical trial access to participate, using virtual contact models, convenient lab sites, shipping medication to participants’ homes, and a broad array of communication methods.