The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers
Goldstein O, Shani S, Gana-Weisz M, Elkoshi N, Casey F, Sun Y, Chandratre K, Cedarbaum J, Blauwendraat C, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, Giladi N, Orr-Urtreger A, Alcalay R. The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers. Journal Of Parkinson's Disease 2025 DOI: 10.1177/1877718x241310722.Peer-Reviewed Original ResearchPolygenic risk scoresPolygenic risk score modelPolygenic risk score associationsLRRK2 G2019S carriersGenetic risk factorsPD riskNon-carriersGenetic groupsDisease riskRisk scoreLRRK2 G2019SRisk factorsEffect of polygenic risk scoresGenetically complex conditionsCalculate polygenic risk scoresG2019S carriersElevated PRSAssessed PD riskAssociated with increased PD riskAshkenazi Jewish ancestryAssociated with PD riskModify disease riskGenotype callsGBA1 variantsLRRK2-G2019S-PD