Dan-Dan Li
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About
Biography
Dan Li (also known as Dan-Dan Li) graduated from Harvard College with a Bachelor of Arts with high honors in Chemical and Physical Biology and a minor in Mathematical Sciences in 2015. She is currently a fifth year MD/PhD candidate doing her PhD study in Former Dean Sten Vermund’s lab on the impact of COVID-19 on women and children. As an aspiring OB, Dan holds issues affecting women and children’s lives close to heart. She is the founder and CEO of Education without Barriers, a 501c(3) nonprofit aims to bridge the education accessibility gaps through free, real-time online education and mentorship for vulnerable children across the globe.
Education & Training
- AB
- Harvard College, Chemical and Physical Biology; Mathematical Sciences (2015)
Research
Overview
Medical Subject Headings (MeSH)
Infectious Disease Medicine; Infectious Disease Transmission, Vertical; Pregnancy; Women's Health
ORCID
0000-0002-6332-1093
Research at a Glance
Yale Co-Authors
Frequent collaborators of Dan-Dan Li's published research.
Publications Timeline
A big-picture view of Dan-Dan Li's research output by year.
Jian Xu, PhD
Krystal Pollitt, PhD, P.Eng.
Marie Brault, PhD
Sten H. Vermund, MD, PhD
11Publications
93Citations
Publications
2022
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity
Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H, Wang J. An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity. Nucleic Acids Research 2022, 50: 12462-12479. PMID: 36416264, PMCID: PMC9757061, DOI: 10.1093/nar/gkac1084.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExon junction complexRNA helicaseRNA interferenceEmbryonic stem cellsPost-transcriptionallyEmbryonic stem cell identityEfficient nuclear exportRNA interference screenCell cycle progression of ESCsPost-transcriptional controlCell cycle regulationStem cell identityCell cycle progressionMaintenance of embryonic stem cellsStem cell pluripotencyLoss of pluripotencyRNA metabolismDEAD-boxCell cycle dysregulationCell identityCycle regulationCell pluripotencyCell cyclePluripotency controlCyclin B1Comparative functional genomics identifies unique molecular features of EPSCs
Malik V, Zang R, Fuentes-Iglesias A, Huang X, Li D, Fidalgo M, Zhou H, Wang J. Comparative functional genomics identifies unique molecular features of EPSCs. Life Science Alliance 2022, 5: e202201608. PMID: 35961778, PMCID: PMC9378845, DOI: 10.26508/lsa.202201608.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEmbryonic stem cellsProteome of embryonic stem cellsComparative functional genomicsHistone modification marksChromatin accessibility featuresModification marksChromatin accessibilityFunctional genomicsRegulatory networksTranslational regulationPluripotency factors OCT4Molecular foundationMaintenance in vitroMolecular underpinningsTotipotent stem cellsMolecular signaturesChromatinFactors Oct4Stem cellsDevelopmental potencySelf-renewalMolecular featuresGenomeCellsTranscriptome
2021
Reopening Schools After a Novel Coronavirus Surge
Li D, Lin EZ, Brault MA, Paquette J, Vermund SH, Godri Pollitt KJ. Reopening Schools After a Novel Coronavirus Surge. Advances In Experimental Medicine And Biology 2021, 1318: 785-813. PMID: 33973212, DOI: 10.1007/978-3-030-63761-3_44.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicGlobal death tollMental health supportPandemic influenzaDisease controlHealth supportSocial isolationNew guidelinesVulnerability of childrenRisk reductionRiskDisease control strategiesSafetyChild safetySpecial considerationDeath tollOpening schoolsPandemic
2019
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.
Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ. Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. Cell Reports 2019, 27: 1376-1386.e6. PMID: 31042466, PMCID: PMC7351313, DOI: 10.1016/j.celrep.2019.04.005.Peer-Reviewed Original Research
2017
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell 2017, 32: 792-806.e7. PMID: 29153843, PMCID: PMC5728174, DOI: 10.1016/j.ccell.2017.10.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProstate cancerCastration resistanceHNF4GCastration-resistant prostate cancerAndrogen deprivation therapyAndrogen receptor signalingPrimary prostate cancerAndrogen requirementAndrogen signalingPhysiologic levelsCancerAberrant activationExogenous expressionActivationSignalingAlternative lineage programsAndrogensTherapyRegulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nature Cell Biology 2017, 19: 626-638. PMID: 28504707, PMCID: PMC5771482, DOI: 10.1038/ncb3527.Peer-Reviewed Original Research
2016
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype.
Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Reports 2016, 16: 3181-3194. PMID: 27653684, PMCID: PMC5054719, DOI: 10.1016/j.celrep.2016.08.064.Peer-Reviewed Original ResearchDynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental Cell 2016, 36: 9-23. PMID: 26766440, PMCID: PMC4714361, DOI: 10.1016/j.devcel.2015.12.014.Peer-Reviewed Original Research
2015
Antibacterial and osteoinductive capability of orthopedic materials via cation-π interaction mediated positive charge.
Shi L, Zhang W, Yang K, Shi H, Li D, Liu J, Ji J, Chu PK. Antibacterial and osteoinductive capability of orthopedic materials via cation-π interaction mediated positive charge. Journal Of Materials Chemistry. B, Materials For Biology And Medicine 2015, 3: 733-737. PMID: 32262162, DOI: 10.1039/c4tb01924e.Peer-Reviewed Original ResearchDevelopmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.
Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell 2015, 57: 304-316. PMID: 25578878, PMCID: PMC4305004, DOI: 10.1016/j.molcel.2014.12.009.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Thomas Temple Hoopes Prize
Other AwardHarvard CollegeDetails05/28/2015United Stateshonor Andrew W. Mellon Scholar
Other AwardDetails08/08/2012United Stateshonor Gates Millennium Scholar
National AwardDetails03/01/2011United States
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