Dean's Workshop: "Stephen & Denise Adams Center for Parkinson’s Disease Research: Building the Future of Precision Neurology"

This workshop introduces our new inter-departmental Stephen & Denise Adams Center for Parkinson’s Disease Research led by founding Director Clemens Scherzer, MD. The session, titled "Building the Future of Precision Neurology," will be held on Thursday, March 27, from 1 to 5 p.m.

The center’s goal is to change the ways that Parkinson’s is diagnosed and treated, including through the use of predictive and preventive precision neurology and the power of genomics and artificial intelligence (AI). The workshop will introduce how the center is bringing together innovative physicians, scientists, and engineers from across Yale and beyond to advance Parkinson’s research and precision neurology in general. It will also discuss advances in decoding the genetic causes and pathophysiology of complex and familial forms of the disease and explore how digital twins and brains-on-chip simulations are facilitating innovative progress with applications for biological discovery, therapeutic targeting, and disease management.

This hybrid event, hosted by the School of Medicine dean’s office, will take place via Zoom and in person in 101 College Street's first floor conference room. As with previous workshops, we will provide a survey at the end to request your feedback.

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STEPHEN & DENISE ADAMS CENTER FOR PARKINSON’S DISEASE RESEARCH: BUILDING THE FUTURE OF PRECISION NEUROLOGY

INTRODUCTION AND WELCOME, 1 - 1:05 PM

Nancy J. Brown, MD, Jean and David W. Wallace Dean of Medicine and C.N.H. Long Professor of Internal Medicine, Yale School of Medicine

DECODING THE GENETIC SOFTWARE OF PARKINSON’S DISEASE, 1:05 - 1:25 PM

Clemens Scherzer, MD, Director of Stephen & Denise Adams Center for Parkinson’s Disease Research; Stephen & Denise Adams Professor of Neurology; and Professor of Genetics and of Neuroscience, Yale School of Medicine

MAPPING THE PARKINSON’S BRAIN IN SPACE AND TIME, 1:25 - 1:45 PM

Xianjun Dong, PhD, Associate Professor of Neurology and Biomedical Informatics & Data Science, Yale School of Medicine; and Stephen & Denise Adams Center of Parkinson’s Disease Research, Yale School of Medicine

DIGITAL GENETICS – DRIVING PRECISION NEUROSCIENCE WITH AI AND BIOSENSORS, 1:45 - 2:05 PM

Jason Liu, PhD, Postdoctoral Associate in the Program in Computational Biology and Biomedical Informatics, Department of Molecular Biophysics and Biochemistry, Yale University

MECHANISMS OF SYNUCLEIN ACCUMULATION: PROGRANULIN, TAU, AND SPREADING, 2:05 - 2:25 PM

Stephen M. Strittmatter, MD, PhD, Chair and Professor of Neuroscience; and Vincent Coates Professor of Neurology, Yale School of Medicine

PANEL DISCUSSION: HOW WILL GENOMICS AND AI ACCELERATE PRECISION MEDICINES? 2:25 - 2:40 PM

Panel Co-Chairs: Vlad Coric, MD, Chief Executive Officer and Chairman of Board at Biohaven and Thomas Biederer, PhD, Professor of Neurology, Yale School of Medicine
Panelists: Scherzer, Dong, Liu, Strittmatter

NETWORKING BREAK, 2:40 - 2:55 PM

LEVERAGING ON CELL BIOLOGY TO UNDERSTAND PARKINSON’S DISEASE, 2:55 - 3:15 PM

Pietro De Camilli, PhD, John Klingenstein Professor of Neuroscience and of Cell Biology, Yale School of Medicine; and Investigator, Howard Hughes Medical Institute

SYNAPTIC DYSFUNCTION IN PARKINSON’S DISEASE, 3:15 - 3:35 PM

Sreeganga Chandra, PhD, Professor of Neurology and of Neuroscience, Yale School of Medicine

~TECH KEYNOTE~

BRAIN ORGANOID MAP FOR PRECISION NEUROSCIENCE AND DRUG DISCOVERY, 3:35 - 3:55 PM

Luke P. Lee, PhD, Professor of Medicine, Harvard Medical School; and Senior Investigator, Brigham & Women’s Hospital

PANEL DISCUSSION: MECHANISMS TO MEDICINES FOR PATIENTS, 3:55 - 4:05 PM

Panel Chair: Jesse M. Cedarbaum, MD, Adjunct Professor of Neurology, Division of Movement Disorders, Yale School of Medicine

Panelists: De Camilli, Chandra, Lee, Vives-Rodriguez

IMPACT: BUILDING THE FUTURE OF PRECISION MEDICINE AT THE ADAMS CENTER AND GLOBALLY, 4:05 - 4:15 PM

Clemens Scherzer, MD, Director of Stephen & Denise Adams Center for Parkinson’s Disease Research; Stephen & Denise Adams Professor of Neurology; and Professor of Genetics and of Neuroscience, Yale School of Medicine

CLOSING REMARKS, 4:15 - 4:20 PM

Nancy J. Brown, MD

NETWORKING RECEPTION WITH REFRESHMENTS, 4:20 - 5:00 PM