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Antidepressants Are Safe: Final Word?
Results from a large umbrella review of 45 meta-analyses that included > 1000 observational studies show that “there is no convincing evidence of a link between antidepressant use and adverse health outcomes.” According to Medscape: “Some experts urge caution in interpreting the results. "While the methods of this review are sound … and the discussion of these meta-analyses is balanced, an important limitation of meta-analysis and umbrella reviews is the risk of reductionism," write Michael Bloch, MD, Victor Avila-Quintero, MD, and Jose Flores, MD, PhD, all from Yale University School of Medicine. The editorialists say determining the risks of medication exposure during pregnancy is "important and of great concern" to families, physicians, and children. "Systematic reviews, meta-analyses, and the umbrella reviews will report more precise estimates of associations that are subject to confounding and bias, leading to false accuracy and certainty," they conclude.
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