Helene Benveniste, MD, PhD
Anthony N. Brady Professor of AnesthesiologyCards
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Appointments
Additional Titles
Vice Chair of Research, Anesthesiology
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
About
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Titles
Anthony N. Brady Professor of Anesthesiology
Vice Chair of Research, Anesthesiology
Biography
Dr. Benveniste is a Professor of Anesthesiology at Yale. She received her Bachelors degree in Mathematics & Physics from Katedralskolen, Denmark, and went on to study at the University of Copenhagen, where she received her MD in 1989 and PhD (Doctor Medicinae) in 1991. As a Research Fellow, she trained in high field magnetic resonance imaging (MRI) at Duke University Medical Center with Dr. G. Allen Johnson and developed techniques for brain imaging focused on neurodegenerative disease processes, including Alzheimer’s Disease. She went on to pursue her internship training in Family Medicine and her residency in Anesthesiology also at Duke University. Dr. Benveniste joined the faculty of Duke University's department of Anesthesiology in 1996, where she continued her work in developing diagnostic MRI based platforms for early detection of AD.
In 2001 Dr. Benveniste joined the department of Anesthesiology at Stony Book Medical Center as faculty and set up a preclinical MRI facility at Brookhaven National Laboratory; PET technology was integrated into her work to measure the bioavailability and pharmacokinetics of psychoactive compounds and anesthetic drugs. In 2015, Dr. Benveniste’s laboratory became involved with studies of the ‘glymphatic pathway’ which is a novel peri-vascular based system in the central nervous system involved in brain waste removal. Dr. Benveniste has received national and international recognition for her work. In November of 2016, Benveniste moved to Yale University, where she joined the Department of Anesthesiology and is expanding her research program in understanding how the glymphatic system and cerebrospinal fluid transport is affected in neurodegenerative disease states and aging.
Appointments
Anesthesiology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Copenhagen, Neurobiology (1991)
- MD
- University of Copenhagen (1986)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-2887-6667
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Hedok Lee
Former YSMSunil Koundal
Jean-Leon Thomas, PhD
Douglas Rothman, PhD
D. S. Fahmeed Hyder, PhD
Kevin Behar, PhD
Brain
Cerebrospinal Fluid
Central Nervous System
Anesthesia
Publications
2026
Exploring Lymphovenous Anastomosis for Alzheimer's Disease: Addressing Brain Lymphatic Dysfunction, Feasibility, and Outcome Metrics.
Brown S, Klimitz F, Kipnis J, Benveniste H, Ringstad G, Eide P, Azizi S, Mecca A, Haykal S, Pomahac B. Exploring Lymphovenous Anastomosis for Alzheimer's Disease: Addressing Brain Lymphatic Dysfunction, Feasibility, and Outcome Metrics. Plastic & Reconstructive Surgery 2026 PMID: 42133667, DOI: 10.1097/prs.0000000000013179.Peer-Reviewed Original ResearchAltmetricOnce-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial
Klausen M, Justesen S, Pedersen J, Rasmussen L, Jensen A, Jensen M, Knorr U, Bergmann M, Holst J, Hartmann B, Koob G, Benveniste H, Volkow N, Ekstrøm C, Knudsen G, Vilsbøll T, Fink-Jensen A. Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial. The Lancet 2026, 407: 1687-1698. PMID: 42070571, DOI: 10.1016/s0140-6736(26)00305-3.Peer-Reviewed Original ResearchCitationsAltmetricPupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF
Demiral S, Benveniste H, Volkow N. Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF. NeuroImage 2026, 334: 121971. PMID: 42066921, PMCID: PMC13245481, DOI: 10.1016/j.neuroimage.2026.121971.Peer-Reviewed Original ResearchCitationsGadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease
Stringer M, Shao X, Lee H, Vallatos A, Arteaga-Reyes C, Clancy U, Chappell F, Manning C, Valdes-Hernandez M, Garcia D, Brown R, Doubal F, Benveniste H, Thrippleton M, Wang D, Wardlaw J, group M. Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease. Cerebral Circulation - Cognition And Behavior 2026, 10: 100528. PMID: 41631279, PMCID: PMC12860635, DOI: 10.1016/j.cccb.2026.100528.Peer-Reviewed Original ResearchCitations
2025
Resolving the mysteries of brain clearance and immune surveillance
Kipnis J, Benveniste H, Eichmann A, Thomas J, Reich D, Lewis L, Tsai L, Drieu A, Bakker E, Kelley D, Lundgaard I, Mestre H, Zott B, Eide P, van Osch M, van Veluw S, Iliff J, Yang A, Santambrogio L, Da Mesquita S, Daneman R, Rustenhoven J, Goldman S, Nedergaard M. Resolving the mysteries of brain clearance and immune surveillance. Neuron 2025, 113: 3908-3923. PMID: 41289996, PMCID: PMC12757055, DOI: 10.1016/j.neuron.2025.10.036.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricA novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
Monte B, Davis J, Zhu X, Xu F, Majchrzak M, Cabral M, Van Nostrand W, Healey B, Koundal S, Lee H, Robinson J, Benveniste H, Van Nostrand W. A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Cerebral Circulation - Cognition And Behavior 2025, 9: 100401. PMID: 41142321, PMCID: PMC12546807, DOI: 10.1016/j.cccb.2025.100401.Peer-Reviewed Original ResearchCitationsAltmetricAge-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Gursky Z, Khan Z, Koundal S, Bhardwaj A, Melgarejo J, Xu K, Chen X, Lin H, Gu X, Lee H, Kipnis J, Dori Y, Tannenbaum A, Santambrogio L, Benveniste H. Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model. Journal Of Clinical Investigation 2025, 135: e182555. PMID: 40663395, PMCID: PMC12404751, DOI: 10.1172/jci182555.Peer-Reviewed Original ResearchCitationsAltmetricFluid and Waste Clearance in Central Nervous System Health and Diseases
El Kamouh M, El Kamouh M, Lenck S, Lehericy S, Benveniste H, Thomas J. Fluid and Waste Clearance in Central Nervous System Health and Diseases. Neurodegenerative Diseases 2025, 25: 145-166. PMID: 40334649, PMCID: PMC12173435, DOI: 10.1159/000546018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricReduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchCitationsAltmetricDoes semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Klausen M, Kuzey T, Pedersen J, Justesen S, Rasmussen L, Knorr U, Mason G, Ekstrøm C, Holst J, Koob G, Benveniste H, Volkow N, Knudsen G, Vilsbøll T, Fink-Jensen A. Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial). BMJ Open 2025, 15: e086454. PMID: 39779270, PMCID: PMC11749217, DOI: 10.1136/bmjopen-2024-086454.Peer-Reviewed Original ResearchCitationsAltmetric
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Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
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Tompkins Memorial Pavilion
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789 Howard Avenue, Fl 3rd, Rm 332
New Haven, CT 06519