Candie Paulsen, PhD
Biography
Research & Publications
Locations
Appointments
Biography
I love exploring the unknown and the thrill and sense of accomplishment that comes with making the unknown familiar. This passion has inspired me to make significant transitions, both conceptually and with methodology, at every stage of my career. I purposefully choose research projects that serve to improve human health as well as stand to make fundamental discoveries of basic biology and physiology. Moreover, I thoroughly enjoy teaching, mentoring, and helping young scientists find the joy in science. As a graduate student with Kate Carroll at the University of Michigan and The Scripps Research Institute in Jupiter, FL, I studied redox regulation of signal transduction cascades important to cancer. As a postdoctoral fellow with David Julius at the University of California, San Francisco, I determined the first structures of an important pain receptor, TRPA1 by cryo-EM. In the Paulsen Lab, we combine my diverse trainings to take a multidisciplinary approach to understand how TRPA1 is regulated and dysregulated by novel natural variants and through protein-protein interactions. This work is carried out with an eye towards discovering what a pain receptor "sees" in a cellular context, how those molecules can modulate its activity basally, and how those interactions may be modified to contribute to the development of chronic pain/inflammation.
Education & Training
- Staff ScientistYale University (2017)
- Staff ScientistUniversity of California, San Francisco (2017)
- Postdoctoral FellowUniversity of California, San Francisco (2017)
- Postdoctoral FellowThe Scripps Research Institute (2012)
- PhDUniversity of Michigan, Chemical Biology (2011)
- BSPurdue University, Genetic Biology (2006)
Activities
- Structure of the human TRPA1 ion channel suggests regulatory mechanismsSouth Hadley, MA, United States 2016Ion Channels Gordon Research Conference
- Structure of the human TRPA1 ion channel suggests regulatory mechanismsLos Angeles, CA, United States 2016Biophysical Society Annual Meeting
- Structure of the human TRPA1 ion channel suggests regulatory mechanismsDedham, MA, United States 2015Helen Hay Whitney Fellowship Retreat
- Activation and Regulatory Mechanisms: Insights From Structures of TRPV1 and TRPA1Leuven, Flanders, Belgium 2015TRP Channel Symposium
- Sulfenylation Goes Global: Probing Intracellular Targets of Hydrogen Peroxide Produced for Growth Factor SignalingJupiter, FL, United States 2011Chemistry Department Seminar
- “Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF SignalingSaint Petersburg, FL, United States 2011Enzyme Mechanisms Conference
- “Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF SignalingSaint Petersburg, FL, United States 2011Enzyme Mechanism Conference
- Painting the Cysteine Chapel: New Tools to Probe Oxidation BiologyAnaheim, CA, United States 2010ASBMB Annual Meeting
- Chemical Dissection of an Essential Redox Switch in Yeast and Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF SignalingLucca, Tuscany, Italy 2010Thiol-Based Redox Regulation and Signaling Gordon Conference
- Chemical Dissection of an Essential Redox Switch in Yeast and Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF SignalingAnn Arbor, MI, United States 2010Chemical-Biology Interface Symposium
- Chemical Dissection of an Essential Redox Switch in YeastWashington, DC, United States 2009American Chemical Society National Meeting
- Chemical Dissection of an Essential Redox Switch in YeastAnn Arbor, MI, United States 2009VAUGHN Symposium
- A Chemical Biology Approach to Probing the Yap1-Gpx3 Redox Relay System in YeastAnn Arbor, MI, United States 2008PECRUM Symposium
- A Chemical Biology Approach to Probing the Yap1-Gpx3 Redox Relay System in YeastAnn Arbor, MI, United States 2008Life Sciences Institute Symposium
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Award in Pain Scholar | Rita Allen Foundation and the American Pain Society | 2018 |
Early Career Research Grant | International Association for the Study of Pain | 2018 |
Howard Hughes Medical Institute Postdoctoral Fellow of the Helen Hay Whitney Foundation | Helen Hay Whitney | 2014 |
Cardiovascular Research Institute T-32 Postdoctoral Fellowship | National Institutes of Helath | 2012 |
Chemistry-Biology Interface NIH T-32 Training Grant | National Institutes of Health | 2009 |
Professional Service
Organization | Role | Date |
---|---|---|
Frontiers in Pain Research | Guest Editor | 2021 - Present |
Communications Biology | Reviewer | 2021 - Present |
Exploratorium After Dark Event | Expert lecturer on the science of peppers and mint (July 2015) and hot sauces (July 2017) | 2015 - 2017 |
Cell | Co-Ad hoc reviewer | 2014 - 2017 |
Nature | Co-Ad Hoc Reviewer | 2014 - 2017 |
Biophysical Society | Member | 2014 - Present |
American Heart Association | Member | 2012 - 2013 |
American Chemical Society | Member | 2006 - 2007 |
Alpha Chi Sigma | Professional chemistry fraternity member | 2003 - Present |