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Candie Paulsen, PhD

Assistant Professor of of Molecular Biophysics and Biochemistry

Appointments

Biography

I love exploring the unknown and the thrill and sense of accomplishment that comes with making the unknown familiar. This passion has inspired me to make significant transitions, both conceptually and with methodology, at every stage of my career. I purposefully choose research projects that serve to improve human health as well as stand to make fundamental discoveries of basic biology and physiology. Moreover, I thoroughly enjoy teaching, mentoring, and helping young scientists find the joy in science. As a graduate student with Kate Carroll at the University of Michigan and The Scripps Research Institute in Jupiter, FL, I studied redox regulation of signal transduction cascades important to cancer. As a postdoctoral fellow with David Julius at the University of California, San Francisco, I determined the first structures of an important pain receptor, TRPA1 by cryo-EM. In the Paulsen Lab, we combine my diverse trainings to take a multidisciplinary approach to understand how TRPA1 is regulated and dysregulated by novel natural variants and through protein-protein interactions. This work is carried out with an eye towards discovering what a pain receptor "sees" in a cellular context, how those molecules can modulate its activity basally, and how those interactions may be modified to contribute to the development of chronic pain/inflammation.

Education & Training

  • Staff Scientist
    Yale University (2017)
  • Staff Scientist
    University of California, San Francisco (2017)
  • Postdoctoral Fellow
    University of California, San Francisco (2017)
  • Postdoctoral Fellow
    The Scripps Research Institute (2012)
  • PhD
    University of Michigan, Chemical Biology (2011)
  • BS
    Purdue University, Genetic Biology (2006)

Activities

  • Selected Speaker
    South Hadley, United States 2016
  • Selected Speaker
    Los Angeles, United States 2016
  • Invited Speaker
    Dedham, United States 2015
  • Invited Speaker
    Leuven, Belgium 2015
  • Invited Speaker
    Jupiter, United States 2011
  • Poster presentation
    Saint Petersburg, United States 2011
  • Poster Presentation
    Saint Petersburg, United States 2011
  • Invited Speaker
    Anaheim, United States 2010
  • Poster Presentation
    Lucca, Italy 2010
  • Poster Presentation
    Ann Arbor, United States 2010
  • Poster presentation
    Washington, United States 2009
  • Poster presentation
    Ann Arbor, United States 2009
  • Invited Speaker
    Ann Arbor, United States 2008
  • Selected Speaker
    Ann Arbor, United States 2008

Honors & Recognition

AwardAwarding OrganizationDate
Award in Pain ScholarRita Allen Foundation and the American Pain Society2018
Early Career Research GrantInternational Association for the Study of Pain2018
Howard Hughes Medical Institute Postdoctoral Fellow of the Helen Hay Whitney FoundationHelen Hay Whitney2014
Cardiovascular Research Institute T-32 Postdoctoral FellowshipNational Institutes of Helath2012
Chemistry-Biology Interface NIH T-32 Training GrantNational Institutes of Health2009

Professional Service

OrganizationRoleDate
Frontiers in Pain ResearchGuest Editor2021 - Present
Communications BiologyReviewer2021 - Present
Exploratorium After Dark EventExpert lecturer on the science of peppers and mint (July 2015) and hot sauces (July 2017)2015 - 2017
CellCo-Ad hoc reviewer2014 - 2017
NatureCo-Ad Hoc Reviewer2014 - 2017
Biophysical SocietyMember2014 - Present
American Heart AssociationMember2012 - 2013
American Chemical SocietyMember2006 - 2007
Alpha Chi SigmaProfessional chemistry fraternity member2003 - Present

Departments & Organizations