2025
Personalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect
Bergemann R, Massey A, Tommasini S, Wiznia D. Personalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect. Journal Of Orthopaedic Surgery And Research 2025, 20: 229. PMID: 40033401, PMCID: PMC11874654, DOI: 10.1186/s13018-025-05606-5.Peer-Reviewed Original ResearchConceptsAdjunctive therapyVolume of boneCore decompressionBone marrow aspirate concentrateRisk of complicationsFemoral headSynthetic bone substituteAmount of boneBone substituteAspirate concentrateExpandable reamerBone regenerationBone graftPrevent collapseDebilitating diseaseReamer systemBoneAdjunctGrafting techniqueDecompressionThe development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas
Jester N, Singh M, Lorr S, Tommasini S, Wiznia D, Buono F. The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas. Scientific Reports 2025, 15: 5918. PMID: 39966622, PMCID: PMC11836447, DOI: 10.1038/s41598-025-88589-x.Peer-Reviewed Original ResearchConceptsGround-truth datasetDice scoreVestibular schwannomaImage processing accuracyVolumetric analysisML-based algorithmsMeasuring tumor sizeMean dice scoreAuto-segmentation toolAccurate AIAI modelsTumor sizeTumor modelVS tumorsTumor growthTesting stageAI-LTumorImage processing softwareClinical practicePatient recruitmentProcessing softwareSchwannomaDatasetManual segmentationCD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections.
Agidigbi T, Fram B, Molloy I, Riedel M, Wiznia D, Oh I. CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections. Clinical Orthopaedics And Related Research® 2025 PMID: 39915095, DOI: 10.1097/corr.0000000000003402.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsFracture-related infectionRibonucleotide reductase regulatory subunit M2Peripheral blood mononuclear cell levelsPeripheral blood mononuclear cell concentrationsPeriprosthetic joint infectionMusculoskeletal infectionsMonitoring treatment responseDiabetic foot infectionsTreatment responseReceiver operating characteristicPurulent drainageControl groupSerum levelsSinus tractInflammatory markersBlood samplesFoot infectionsInfection groupDiagnostic accuracyTranscriptomic analysis of peripheral blood mononuclear cellsDiagnosis of musculoskeletal infectionsNormalization of inflammatory markersPeripheral blood mononuclear cells of patientsInflammatory conditionsMusculoskeletal Magazine Advertising Focuses on White Individuals and Overlooks Minority Consumers
Tung W, Rankin K, Oris R, Wijesekera A, Wiznia D. Musculoskeletal Magazine Advertising Focuses on White Individuals and Overlooks Minority Consumers. Journal Of Market Access & Health Policy 2025, 13: 4. PMID: 39990185, PMCID: PMC11843984, DOI: 10.3390/jmahp13010004.Peer-Reviewed Original ResearchHealth-related advertisingImprove patient perceptionsUS population demographicsDirect-to-consumer advertisingAdvertising categoriesCross-sectional analysisBlack modelHealth disparitiesHealth existChi-square testInfluence consumer behaviorWhite individualsWhite modelFisher's exact testDemographic disparitiesDisparitiesPain reliefBuying patternsConsumer behaviorMinority consumersPopulation demographicsExact testRacial distributionAdjacent industriesMSKMedical Student Musculoskeletal Knowledge: Examining the Impact and Value of an Orthopaedic Surgery Clerkship Using the Freedman and Bernstein Examination
Nishime N, Seibel M, Lindskog D, Wiznia D. Medical Student Musculoskeletal Knowledge: Examining the Impact and Value of an Orthopaedic Surgery Clerkship Using the Freedman and Bernstein Examination. BMC Medical Education 2025, 25: 141. PMID: 39881308, PMCID: PMC11776173, DOI: 10.1186/s12909-025-06673-2.Peer-Reviewed Original ResearchConceptsMusculoskeletal knowledgePost-test scoresMusculoskeletal examinationPost-testPre-testSurgery clerkshipThree-week clerkshipPost-clerkship surveysOrthopaedic surgery departmentsOrthopaedic surgery residentsMedical schoolsMethodsMedical studentsSurgery departmentClerkshipSurgery residentsAverage scoreRaw scoresScoresWeighted scoreOrthopaedicsExaminationTau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei Z, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia D, Xu H, Chen Z, Chen L, Tang K, Zhou H, Liu C. Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Cell Research 2025, 35: 23-44. PMID: 39743632, PMCID: PMC11701132, DOI: 10.1038/s41422-024-01016-0.Peer-Reviewed Original ResearchConceptsGC-induced osteoporosisBone lossInflammatory arthritisAdverse effects of dexamethasoneGlucocorticoid-induced bone lossHigh-dose dexamethasoneEffect of dexamethasoneFDA-approved drug librarySynthetic GCTreat inflammatory arthritisImmunosuppressive drugsPrescribed anti-inflammatoryGC receptorCombinatorial administrationSide effectsLow affinityGlucocorticoidOsteoporosisDexamethasoneReceptorsAdverse effectsBinding receptorsAnti-inflammatoryDrug libraryTau deficiency
2024
Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion.
Kim L, Wiznia D, Grauer J. Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39630933, DOI: 10.5435/jaaos-d-24-00299.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitorsDM patientsAdverse eventsDiabetes mellitusTotal knee arthroplastySGLT2i useElixhauser Comorbidity IndexComorbidity indexMultivariate analysisIncidence of blood transfusionReduced risk of transfusionAssociated with multiple complicationsOdds of transfusionUrinary tract infectionAssociated with increased riskPerioperative adverse outcomesRisk of transfusionAssociated with reduced incidenceAcute kidney injuryPostoperative adverse eventsSurgical decision makingControlled DM patientsActive tobacco useGroup of medicationsAssociated with higher oddsMethods to Manage Edema and Reduce Flap Compression in Postoperative Nursing Care Following Trauma to the Lower Extremity
Rancu A, Darby F, Averbukh L, Nicholson A, Myrick K, Leslie M, Wiznia D. Methods to Manage Edema and Reduce Flap Compression in Postoperative Nursing Care Following Trauma to the Lower Extremity. Orthopaedic Nursing 2024, 43: 325-329. PMID: 39630519, DOI: 10.1097/nor.0000000000001075.Peer-Reviewed Original Research In PressConceptsLower extremity traumaExtremity traumaAcute care settingPostoperative nursing careNurse managersOrthopaedic nursesNursing careSoft tissue coverage techniquesPostoperative nursing managementCare settingsLower-extremitySoft tissue coverage proceduresLower extremitiesReduce edemaPoor soft tissue healingTraumatic injuryLiterature reviewTraumaNursesExtremitiesLower extremity edemaPatientsCareSoft tissue healingReviewImpact of Surgeon Volume on Perioperative Complications and Survival to Total Hip Arthroplasty Following Femoral Head Core Decompression
Sanchez J, Jiang W, Dhodapkar M, Radford Z, Seddio A, Li M, Wiznia D, Grauer J. Impact of Surgeon Volume on Perioperative Complications and Survival to Total Hip Arthroplasty Following Femoral Head Core Decompression. JAAOS Global Research And Reviews 2024, 8: e24.00153. PMCID: PMC11578193, DOI: 10.5435/jaaosglobal-d-24-00153.Peer-Reviewed Original ResearchFemoral head osteonecrosisHip fractureInvasive proceduresCore decompressionHigh-volume surgeon groupImpact of surgeon volumeTotal hip arthroplastyKaplan-Meier survival analysisHigh-volume surgeonsMinimally invasive procedureSurgeon volume categoriesStatistically significant differenceAssess complicationsPerioperative complicationsPostoperative complicationsElixhauser Comorbidity IndexAdult patientsVolume surgeonsTreatment optionsAdverse eventsSurgeon volumeSurgeon groupComorbidity indexMultivariate analysisComplicationsVisualization of Trochlear Dysplasia Using 3-Dimensional Curvature Analysis in Patients With Patellar Instability Facilitates Understanding and Improves the Reliability of the Entry Point to Trochlea Groove Angle
Sieberer J, Park N, Manafzadeh A, Desroches S, Brennan K, McDonald C, Tommasini S, Wiznia D, Fulkerson J. Visualization of Trochlear Dysplasia Using 3-Dimensional Curvature Analysis in Patients With Patellar Instability Facilitates Understanding and Improves the Reliability of the Entry Point to Trochlea Groove Angle. Arthroscopy Sports Medicine And Rehabilitation 2024, 7: 101010. PMID: 40041820, PMCID: PMC11873473, DOI: 10.1016/j.asmr.2024.101010.Peer-Reviewed Original ResearchPatellofemoral instability patientsInterclass correlation coefficientInterrater reliabilityPatellofemoral instabilityLevel III-retrospective cohort studyResults Qualitative analysisIII-retrospective cohort studyTrochlear grooveClinical decision-makingRetrospective cohort studyAge-sex matched controlsCohort studyMann-Whitney U testAge-sexRecurrent patellar instabilityPatient's kneeControl kneesAP viewMatched controlsKneePatellar instabilityCT scanTrochlear dysplasiaMann-WhitneyU testAnalyzing Alignment Error in Tibial Tuberosity–Trochlear Groove Distance in Clinical Scans Using 2D and 3D Methods
Sieberer J, Park N, Rancu A, Desroches S, McDonald C, Manafzadeh A, Tommasini S, Wiznia D, Fulkerson J. Analyzing Alignment Error in Tibial Tuberosity–Trochlear Groove Distance in Clinical Scans Using 2D and 3D Methods. The American Journal Of Sports Medicine 2024, 52: 2996-3003. PMID: 39320426, DOI: 10.1177/03635465241279852.Peer-Reviewed Original ResearchTibial tuberosity-trochlear groove distanceSurgical decision-makingPatellofemoral instabilityIntraclass correlation coefficientGroove distanceTreatment of patellofemoral instabilityComputed tomography scanTT-TG distanceScans of patientsPatient's legsTT-TG measurementsTibial tubercle transferKnees of patientsInterrater reliabilityGt;5 mmTomography scanSurgical planningTubercle transferScanner gantryPatientsClinical scansClinical literatureTopographic landmarksKneeDecision-makingRobotic Arm–Assisted Total Knee Arthroplasty Results in Smaller Femoral Components and Larger Tibial Baseplates Than the Manual Technique
Bernstein J, Hepinstall M, Donnelley C, Rajahraman V, Waren D, Schwarzkopf R, Wiznia D. Robotic Arm–Assisted Total Knee Arthroplasty Results in Smaller Femoral Components and Larger Tibial Baseplates Than the Manual Technique. Arthroplasty Today 2024, 29: 101414. PMID: 39529977, PMCID: PMC11551327, DOI: 10.1016/j.artd.2024.101414.Peer-Reviewed Original ResearchTotal knee arthroplastyMultivariate analysisImplant sizeTotal knee arthroplasty resultsThree-dimensional planningAcademic medical centerImplant size selectionManual cohortEffect modificationInstrumented total knee arthroplastyClinical outcomesImplant selectionMedical CenterCohortProsthetic designRobotic systemArthroplasty resultsKnee arthroplastyFemoral componentManual techniquesTibial componentNational trends in musculoskeletal urgent care centers: Improved Medicaid access from 2019 to 2023
Dlott C, O’Marr J, Jain S, Metcalfe T, Kayani J, Bahel A, Wiznia D. National trends in musculoskeletal urgent care centers: Improved Medicaid access from 2019 to 2023. Medicine 2024, 103: e38936. PMID: 39093793, PMCID: PMC11296439, DOI: 10.1097/md.0000000000038936.Peer-Reviewed Original ResearchOrthopaedic Nurse Navigators and Total Joint Arthroplasty Preoperative Optimization
Kebeh M, Dlott C, Kurek D, Tung W, Morris J, Wiznia D. Orthopaedic Nurse Navigators and Total Joint Arthroplasty Preoperative Optimization. Orthopaedic Nursing 2024, 43: 195-201. PMID: 39047269, PMCID: PMC11279383, DOI: 10.1097/nor.0000000000001039.Peer-Reviewed Original ResearchConceptsNurse navigatorPayer statusMedical managementMedical management guidelinesMedication reconciliationResource referralsPatient educationInsurance statusPreoperative optimization protocolFinancial concernsInsurance coveragePatient outcomesLiterature searchNursesTJA patientsManagement guidelinesPayersMedicationStatusInsuranceFinancial resourcesEducationPatientsRecommendationsReferralPoster 251: Tibial Tuberosity to Trochlear Groove Distance (TT-TG): A Patellar Instability Gold Standard Prone to Errors?
Sieberer J, Park N, Rancu A, Manafzadeh A, Tommasini S, Wiznia D, Fulkerson J. Poster 251: Tibial Tuberosity to Trochlear Groove Distance (TT-TG): A Patellar Instability Gold Standard Prone to Errors? Orthopaedic Journal Of Sports Medicine 2024, 12: 2325967124s00220. PMCID: PMC11328310, DOI: 10.1177/2325967124s00220.Peer-Reviewed Original ResearchClinical decision-makingAngular malalignmentLongitudinal tibial axisDistal pointTT-TGClinical practiceTrochlear grooveAxial alignmentLateral patellofemoral instabilityPatellar instabilityError prevalenceKnee alignmentPatient careTibial axisDecision-makingKneeMann-Whitney U testRadiological protocolPatient's kneeFemoral posterior condylesInstitutional review boardTT-TG distanceCoronal angleExclusion criteriaControl kneesPoster 291: Entry Point-Transition Point Angle as a Novel 3-Dimensional Metric of Patellar Instability
Park N, Sieberer J, Rancu A, Manafzadeh A, McDonald C, Yu K, Wiznia D, Fulkerson J. Poster 291: Entry Point-Transition Point Angle as a Novel 3-Dimensional Metric of Patellar Instability. Orthopaedic Journal Of Sports Medicine 2024, 12: 2325967124s00258. PMCID: PMC11328264, DOI: 10.1177/2325967124s00258.Peer-Reviewed Original ResearchPatellar instabilityComputed tomographyTrochlear dysplasiaGeneral populationRecurrent dislocationDegree of dysplasiaRecurrent patellar dislocationMann-Whitney U testInstitutional review board exemptionDistal femurGeneral population cohortPatellofemoral painPatellar dislocationMann-WhitneyU testCT imagesDysplasiaAnteroposterior viewPatientsTrochlear morphologyInterclass correlationPopulation cohortNew Mexico Decedent Image DatabaseCohortFemurUsing preoperative planning software to assess the effect of head length on prosthetic range of motion in a high-risk population: a three-dimensional modeling study
Eslam Pour A, Tung W, Donnelley C, Tommasini S, Wiznia D. Using preoperative planning software to assess the effect of head length on prosthetic range of motion in a high-risk population: a three-dimensional modeling study. International Orthopaedics 2024, 48: 2403-2410. PMID: 38767711, DOI: 10.1007/s00264-024-06191-8.Peer-Reviewed Original ResearchProsthetic range of motionPreoperative planning softwareRange of motionMethodsForty-three patientsTotal hip arthroplastyExternal rotationPlanning softwareHigh-risk populationPreoperative templatingCT-based modelSurgical planningPrimary total hip arthroplastyHip extensionMaximum external rotationProsthetic head diameterOutcome variablesRisk of impingementSurgeonsHipHip arthroplastyProsthetic impingementSustentaculum fracture fixation with lateral plate or medial screw fixation are equivalent
Roytman G, Salameh M, Rizzo S, Dhodapkar M, Tommasini S, Wiznia D, Yoo B. Sustentaculum fracture fixation with lateral plate or medial screw fixation are equivalent. Injury 2024, 55: 111532. PMID: 38614015, DOI: 10.1016/j.injury.2024.111532.Peer-Reviewed Original ResearchSubtalar jointCadaveric anklesSustentaculum tali fracturesFresh-frozen cadaveric anklesT-testAssess patient outcomesPaired t-testUn-paired t-testAnkle modelAnkleRight ankleLeft ankleMid-tibiaPatient outcomesRetrospective observational studyScrew fixationObservational studyMethod of fixationFracture fixationBiomechanical functionMedial approachBody massFixation methodsInterosseous ligamentNo significant differenceOrthopaedic Nurse Navigators and Total Joint Arthroplasty Preoperative Optimization
Kebeh M, Dlott C, Tung W, Wiznia D. Orthopaedic Nurse Navigators and Total Joint Arthroplasty Preoperative Optimization. Orthopaedic Nursing 2024, 43: 132-140. PMID: 38861742, PMCID: PMC11178248, DOI: 10.1097/nor.0000000000001026.Peer-Reviewed Original ResearchConceptsNurse navigatorMental healthHousing statusTotal joint arthroplastyHousing concernsTotal joint arthroplasty patientsEligibility criteriaScreening toolPrevent patientsHealthImplement protocolsImproving postoperative outcomesLiterature searchIncreased focusLack of standardized protocolsJoint arthroplastyStatusStandard protocolNursesOutcomesPatientsConcernsPostoperative outcomesDecrease surgical riskRiskFabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis
Bell C, Feizi A, Roytman G, Ramji A, Tommasini S, Wiznia D. Fabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis. 3D Printing In Medicine 2024, 10: 10. PMID: 38564090, PMCID: PMC10986134, DOI: 10.1186/s41205-024-00208-z.Peer-Reviewed Original Research
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