Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchMeSH KeywordsAlarminsAntibodies, AntiphospholipidBlotting, WesternCell LineDNA, MitochondrialExtracellular VesiclesFemaleHumansPlacentaPre-EclampsiaPregnancyConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patternsLow molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies
Quao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology 2017, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeAspirinBeta 2-Glycoprotein ICells, CulturedChemokinesDisease ProgressionDrug Therapy, CombinationEndometriumEndothelial CellsFemaleHeparin, Low-Molecular-WeightHumansMembrane ProteinsNeovascularization, PhysiologicPregnancyPregnancy ComplicationsTrophoblastsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsLow molecular weight heparinHuman endometrial endothelial cellsMolecular weight heparinUterine endotheliumAntiphospholipid antibodiesWeight heparinInfluence of LMWHLow dose low molecular weight heparinAnti-angiogenic sFlt-1Chemokine MCP-1Endometrial endothelial cellsEffects of aPLSFlt-1 releaseAngiogenic factor secretionObstetric APSPregnancy complicationsControl IgGChemokine profilesEndothelium dysfunctionChemokine secretionPro-angiogenic VEGFCombination therapySFlt-1Impaired placentationMCP-1