Publications

Featured Publications

Placental Pathology Findings in Unexplained Pregnancy Losses
Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.
Peer-Reviewed Original Research
Concepts
Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study
Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*
KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta
Morris N, Guller S, Tang Z, Zhang Y, Siegman E, Milano K, Rudnick G, Kliman H. Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta. Endocrinology 2025, 166: bqaf124. PMID: 40898405, PMCID: PMC12399332, DOI: 10.1210/endocr/bqaf124.
Peer-Reviewed Original Research
This study investigates how serotonin affects placental gene expression and growth, showing its critical role in embryonic development via nuclear protein modification called serotonylation.
Full Summary
Pathway of Maternal Serotonin to the Human Embryo and Fetus
Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.
Peer-Reviewed Original Research
MeSH Keywords
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes
Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2020, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Comment on “The placenta harbors a unique microbiome”
Kliman HJ. Comment on “The placenta harbors a unique microbiome”. Science Translational Medicine 2014, 6: 254le4-254le4. PMID: 25232175, DOI: 10.1126/scitranslmed.3009864.
Commentaries, Editorials and Letters
MeSH Keywords and Concepts
Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss
Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Improved endometrial assessment using cyclin E and p27
Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-156. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
An experimental test of the ovulatory homolog model of female orgasm
Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Type I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume
Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal Of Obstetrics And Gynecology 2017, 218: 126.e1-126.e13. PMID: 29097177, DOI: 10.1016/j.ajog.2017.10.024.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2026

2024

Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.
Peer-Reviewed Original Research
Concepts

2023

Progress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

2022

2021

Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus
Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

See All Publications

Publications

Featured Publications

Placental Pathology Findings in Unexplained Pregnancy Losses

Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study

Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*

Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta

Pathway of Maternal Serotonin to the Human Embryo and Fetus

Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface

Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes

Comment on “The placenta harbors a unique microbiome”

Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss

Improved endometrial assessment using cyclin E and p27

An experimental test of the ovulatory homolog model of female orgasm

Type I interferons instigate fetal demise after Zika virus infection

First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume

2026

Absence of SARS-CoV-2 in Placental Tissue After Maternal COVID-19

Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance

Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (Macaca mulatta)

2024

Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation

2023

Progress on the Endometrium

2022

Sex differences in early and term placenta are conserved in adult tissues

X chromosome inactivation in the human placenta is patchy and distinct from adult tissues

Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity

Pathologic Assessment of the Placenta: Evidence Compared With Tradition

X chromosome inactivation in the human placenta is patchy and distinct from adult tissues

Trophoblast inclusions and adverse birth outcomes

2021

Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus